葡萄糖酸铬

Description

chromium gluconate · CAS 33661-40-4 · C18H33CrO21. UNII V236ZVR3RL.

Identification

CAS Registry Number	33661-40-4
PubChem CID	71587119
Molecular formula	C18H33CrO21
IUPAC name	chromium(3+);tris((2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate)
UNII (FDA)	V236ZVR3RL

Computed Descriptors

Molecular Weight	637.4
Hydrogen Bond Donor Count	15
Hydrogen Bond Acceptor Count	21
Rotatable Bond Count	12
Exact Mass	637.091938
Monoisotopic Mass	637.091938
Topological Polar Surface Area	424
Heavy Atom Count	40
Formal Charge	0
Complexity	165

Documented Uses

• Indicated for use as a supplement to intravenous solutions given for total parenteral nutrition (TPN), to maintain chromium serum levels and to prevent depletion of endogenous stores and subsequent deficiency symptoms.
• Chromium compounds are both absorbed by the lung and the gastrointestinal tract. Oral absorption of chromium compounds in humans can range between 0.5% and 10%, with the hexavalent (VI) chromium more easily absorbed than the trivalent (III) form. Absorption of chromium from the intestinal tract is low, ranging from less than 0.4% to 2.5% of the amount consumed. Vitamin C and the vitamin B niacin is reported to enhance chromium absorption. Most hexavalent Cr (VI) undergoes partial intragastric reduction to Cr (III)
• Absorbed chromium is excreted mainly in the urine, accounting for 80% of total excretion of chromium; small amounts are lost in hair, perspiration and bile. Chromium is excreted primarily in the urine by glomerular filtration or bound to a low molecular-weight organic transporter.
• Absorbed chromium is distributed to all tissues of the body and its distribution in the body depends on the species, age, and chemical form. Circulating Cr (III) following oral or parenteral administration of different compounds can be taken up by tissues and accumulates in the liver, kidney, spleen, soft tissue, and bone.
• Excretion of chromium is via the kidneys ranges from 3 to 50 μg/day. The 24-hour urinary excretion rates for normal human subjects are reported to be 0.22 μg/day.
• In the blood, 95% of chromium (III) is bound to large molecular mass proteins, such as transferrin, while a small proportion associates with low molecular mass oligopeptides. Serum chromium is bound to transferrin in the beta globulin fraction.

Synonyms

Chromium gluconate; UNII-V236ZVR3RL; V236ZVR3RL; 33661-40-4; chromium(III) gluconate; DTXSID20187342; D-GLUCONIC ACID, CHROMIUM SALT; RefChem:125875; DTXCID30109833; SCHEMBL537856; Chromium(3+) tri(D-gluconate); EBC-27402; DB14528; Q27291428

Frequently Asked Questions

What are the CAS number and molecular formula of chromium gluconate?

CAS 33661-40-4; molecular formula C18H33CrO21; molecular weight — g/mol.

What other names is chromium gluconate known by?

Chromium gluconate, UNII-V236ZVR3RL, V236ZVR3RL, 33661-40-4, chromium(III) gluconate, DTXSID20187342.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.