皮质瑞林羊三氟甲酸盐

Description

Corticorelin Ovine Triflutate · CAS 121249-14-7 · C205H339N59O63S. UNII 56X54T817Q.

Identification

CAS Registry Number	121249-14-7
PubChem CID	16132344
Molecular formula	C205H339N59O63S
UNII (FDA)	56X54T817Q

Computed Descriptors

Molecular Weight	4670
XLogP3	-18.6
Hydrogen Bond Donor Count	66
Hydrogen Bond Acceptor Count	71
Rotatable Bond Count	161
Exact Mass	4669.4924539
Monoisotopic Mass	4667.4857443
Topological Polar Surface Area	2010
Heavy Atom Count	328
Formal Charge	0

Physical description & handling notes

• In normal subjects, intravenous administration of corticorelin results in a rapid and sustained increase of plasma ACTH levels and a near parallel increase of plasma cortisol. In addition, intravenous administration of corticorelin to normal subjects causes a concomitant and prolonged release of the related proopiomelanocortin peptides β- and γ-lipotropins (β -and γ-LPH) and β-endorphin (β -END).

Documented Uses

• Corticorelin is indicated for use in differentiating pituitary and ectopic production of ACTH in patients with ACTH-dependent Cushing's syndrome.
• Plasma ACTH levels in normal subjects increased 2 minutes after injection of corticorelin doses of ≥0.3 mcg/kg and reached peak levels after 10-15 minutes. Plasma cortisol levels increased within 10 minutes and reached peak levels at 30 to 60 minutes.
• The mean volume of distribution for IR-corticorelin is 6.2 ± 0.5 L
• Corticorelin does not appear to be bound specifically by a circulating plasma protein.
• Plasma half-lives for IR-corticorelin are 11.6 ± 1.5 minutes (mean ± SE) for the fast component and 73 ± 8 minutes for the slow component.
• Corticorelin is a potent stimulator of adrenocorticotropic hormone (ACTH) release from the anterior pituitary. It is used as a diagnostic agent to evaluate the status of the pituitary-adrenal axis in the differentiation of a pituitary source from an ectopic source of excessive ACTH secretion.

Synonyms

Corticorelin ovine triflutate; Corticorelin triflutate; 56X54T817Q; RefChem:58077; 121249-14-7; Acthrel; Corticorelin ovine; Ovine CRH; 79804-71-0; Ovine ACTH releasing factor; Ovine CRF 41; Ovine corticotropin-releasing factor; Corticotropin-releasing factor (sheep); Sheep corticotropin-releasing factor (1-41); Corticotropin-releasing factor (sheep hypothalamus); Ovine CRF

Frequently Asked Questions

What are the CAS number and molecular formula of Corticorelin Ovine Triflutate?

CAS 121249-14-7; molecular formula C205H339N59O63S; molecular weight — g/mol.

What other names is Corticorelin Ovine Triflutate known by?

Corticorelin ovine triflutate, Corticorelin triflutate, 56X54T817Q, RefChem:58077, 121249-14-7, Acthrel.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.