Alfuzosin

CAS 81403-80-7C19H27N5O4MW 389.4

Alfuzosin (CAS 81403-80-7) — formula C19H27N5O4, molecular weight 389.4.

Product Overview

CAS Number	81403-80-7
Molecular Formula	C19H27N5O4
Molecular Weight	389.4
Melting Point	240
Boiling Point	688
LogP	1.604
Applications	Uses: Medication: antihypertensive, Use (kg, approx.) in Germany (2009): >250, Consumption (g per capita, approx.) in Germany (2009): 0.00305, Calculated removal (%): 9.2, Formulations, Preparations: Oral: Tablets, extended-release 10 mg Uroxatral (with povidone), (Sanofi-Synthelabo)., Uroxatral, General Manufacturing Information: Preparation: P.M.J. Manoury, DE 2904445, idem, US 4315007 (1979, 1982 both to Synthelabo), Information available in 2004 indicated that Alfuzosin was used in the manufacture of pharmaceutical preparations in the following countries: Argentina, Romania, Information available in 2004 indicated that Alfuzosin hydrochloride was used in the manufacture of pharmaceutical preparations in the following countries: Algeria, Argentina, Austria, Belgium, Brazil, Canada, Chile, Colombia, Costa Rica, Czech Republic, Denmark, Dominican Republic, Ecuador, El Salvador, Finland, France, Germany, Greece, Guatemala, Honduras, Hong Kong, Hungary, Ireland, Israel, Italy, Luxembourg, Malaysia, Netherlands, Nicaragua, Norway, Panama, Poland, Portugal, Russian Federation, Singapore, South Africa, Spain, Sweden, Switzerland, Thailand, Turkey, United Kingdom, USA, Yugoslavia (1, 2), Alfuzosin hydrochloride

Applications

Documented applications: Uses: Medication: antihypertensive, Use (kg, approx.) in Germany (2009): >250, Consumption (g per capita, approx.) in Germany (2009): 0.00305, Calculated removal (%): 9.2, Formulations, Preparations: Oral: Tablets, extended-release 10 mg Uroxatral (with povidone), (Sanofi-Synthelabo)., Uroxatral, General Manufacturing Information: Preparation: P.M.J. Manoury, DE 2904445, idem, US 4315007 (1979, 1982 both to Synthelabo), Information available in 2004 indicated that Alfuzosin was used in the manufacture of pharmaceutical preparations in the following countries: Argentina, Romania, Information available in 2004 indicated that Alfuzosin hydrochloride was used in the manufacture of pharmaceutical preparations in the following countries: Algeria, Argentina, Austria, Belgium, Brazil, Canada, Chile, Colombia, Costa Rica, Czech Republic, Denmark, Dominican Republic, Ecuador, El Salvador, Finland, France, Germany, Greece, Guatemala, Honduras, Hong Kong, Hungary, Ireland, Israel, Italy, Luxembourg, Malaysia, Netherlands, Nicaragua, Norway, Panama, Poland, Portugal, Russian Federation, Singapore, South Africa, Spain, Sweden, Switzerland, Thailand, Turkey, United Kingdom, USA, Yugoslavia (1, 2), Alfuzosin hydrochloride.

Technical Profile

What this product is

Alfuzosin is a chemical compound with CAS registry number 81403-80-7 and molecular formula C19H27N5O4 (molecular weight 389.4).

Identification

CAS number: 81403-80-7

Its molecular formula C19H27N5O4 comprises 19 C, 27 H, 5 N, 4 O atoms.

Also known as: Alfuzosin · 阿夫唑嗪

Frequently Asked Questions

What is the CAS number of Alfuzosin?

The CAS registry number of Alfuzosin is 81403-80-7.

What is the molecular formula and molecular weight of Alfuzosin?

Molecular formula C19H27N5O4, molecular weight 389.4.

What other names is Alfuzosin known by?

It is also registered under: Alfuzosin, 阿夫唑嗪.

What are the documented applications of Alfuzosin?

Recorded applications: Uses: Medication: antihypertensive, Use (kg, approx.) in Germany (2009): >250, Consumption (g per capita, approx.) in Germany (2009): 0.00305, Calculated removal (%): 9.2, Formulations, Preparations: Oral: Tablets, extended-release 10 mg Uroxatral (with povidone), (Sanofi-Synthelabo)., Uroxatral, General Manufacturing Information: Preparation: P.M.J. Manoury, DE 2904445, idem, US 4315007 (1979, 1982 both to Synthelabo), Information available in 2004 indicated that Alfuzosin was used in the manufacture of pharmaceutical preparations in the following countries: Argentina, Romania, Information available in 2004 indicated that Alfuzosin hydrochloride was used in the manufacture of pharmaceutical preparations in the following countries: Algeria, Argentina, Austria, Belgium, Brazil, Canada, Chile, Colombia, Costa Rica, Czech Republic, Denmark, Dominican Republic, Ecuador, El Salvador, Finland, France, Germany, Greece, Guatemala, Honduras, Hong Kong, Hungary, Ireland, Israel, Italy, Luxembourg, Malaysia, Netherlands, Nicaragua, Norway, Panama, Poland, Portugal, Russian Federation, Singapore, South Africa, Spain, Sweden, Switzerland, Thailand, Turkey, United Kingdom, USA, Yugoslavia (1, 2), Alfuzosin hydrochloride.

PubChem Public Data

Independent reference data for Alfuzosin (CAS 81403-80-7), compiled from public chemistry databases.

Registry identifiers across databases

CAS Registry Number	81403-80-7
PubChem CID	2092
Molecular formula	C19H27N5O4
IUPAC name	N-[3-[(4-amino-6,7-dimethoxyquinazolin-2-yl)-methylamino]propyl]oxolane-2-carboxamide
UNII (FDA)	90347YTW5F

Computed descriptors

Molecular Weight	389.4
XLogP3	1.7
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	8
Exact Mass	389.20630436
Monoisotopic Mass	389.20630436
Topological Polar Surface Area	112
Heavy Atom Count	28

Physicochemical values on record

Boiling Point	688
Melting Point	240
Solubility	2.82e-01 g/L
LogP	1.604
LogP	1.4
LogP	1.93
Dissociation Constants	8.13
Dissociation Constants	pKa = 8.13

Documented uses on record

Synonyms and trade names

alfuzosin; 81403-80-7; Alfuzosina; Alfuzosine; Alfuzosinum; NSC-760065; N-{3-[(4-amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino]propyl}oxolane-2-carboxamide; 90347YTW5F; N-(3-((4-Amino-6,7-dimethoxy-2-quinazolinyl)methylamino)propyl)tetrahydro-2-furancarboxamide; DTXSID6048549; CHEBI:51141; alphuzosine; N-[3-[(4-amino-6,7-dimethoxy-2-quinazolinyl)methylamino]propyl]tetrahydro-2-furancarboxamide; alfusozine; N-(3-((4-amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)oxolane-2-carboxamide; N-(3-((4-imino-6,7-dimethoxy-3,4-dihydroquinazolin-2-yl)(methyl)amino)propyl)oxolane-2-carboximidic acid

GHS hazard classification

Reported hazard statements	H373 (100%)

H373 (100%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

P260, P319, and P501 (click each P-code to see the statement)

What the public record says

Alfuzosin · CAS 81403-80-7 · C19H27N5O4. UNII 90347YTW5F. Boiling Point: 688; Melting Point: 240; Solubility: 2.82e-01 g/L.

Physical description and handling notes

Source: PubChem / Wikidata; the batch COA governs where values differ.