阿夫唑嗪（CAS 81403-80-7）：分子式 C19H27N5O4、分子量 389.4。
| CAS号 | 81403-80-7 |
|---|---|
| 分子式 | C19H27N5O4 |
| 分子量 | 389.4 |
| 熔点 | 240 |
| 沸点 | 688 |
| LogP | 1.604 |
| 应用领域 | Uses: Medication: antihypertensive、Use (kg、approx.) in Germany (2009): >250、Consumption (g per capita、approx.) in Germany (2009): 0.00305、Calculated removal (%): 9.2、Formulations、Preparations: Oral: Tablets、extended-release 10 mg Uroxatral (with povidone)、(Sanofi-Synthelabo).、Uroxatral、General Manufacturing Information: Preparation: P.M.J. Manoury、DE 2904445、idem、US 4315007 (1979、1982 both to Synthelabo)、Information available in 2004 indicated that Alfuzosin was used in the manufacture of pharmaceutical preparations in the following countries: Argentina、Romania、Information available in 2004 indicated that Alfuzosin hydrochloride was used in the manufacture of pharmaceutical preparations in the following countries: Algeria、Argentina、Austria、Belgium、Brazil、Canada、Chile、Colombia、Costa Rica、Czech Republic、Denmark、Dominican Republic、Ecuador、El Salvador、Finland、France、Germany、Greece、Guatemala、Honduras、Hong Kong、Hungary、Ireland、Israel、Italy、Luxembourg、Malaysia、Netherlands、Nicaragua、Norway、Panama、Poland、Portugal、Russian Federation、Singapore、South Africa、Spain、Sweden、Switzerland、Thailand、Turkey、United Kingdom、USA、Yugoslavia (1、2)、Alfuzosin hydrochloride |
登记用途：Uses: Medication: antihypertensive、Use (kg、approx.) in Germany (2009): >250、Consumption (g per capita、approx.) in Germany (2009): 0.00305、Calculated removal (%): 9.2、Formulations、Preparations: Oral: Tablets、extended-release 10 mg Uroxatral (with povidone)、(Sanofi-Synthelabo).、Uroxatral、General Manufacturing Information: Preparation: P.M.J. Manoury、DE 2904445、idem、US 4315007 (1979、1982 both to Synthelabo)、Information available in 2004 indicated that Alfuzosin was used in the manufacture of pharmaceutical preparations in the following countries: Argentina、Romania、Information available in 2004 indicated that Alfuzosin hydrochloride was used in the manufacture of pharmaceutical preparations in the following countries: Algeria、Argentina、Austria、Belgium、Brazil、Canada、Chile、Colombia、Costa Rica、Czech Republic、Denmark、Dominican Republic、Ecuador、El Salvador、Finland、France、Germany、Greece、Guatemala、Honduras、Hong Kong、Hungary、Ireland、Israel、Italy、Luxembourg、Malaysia、Netherlands、Nicaragua、Norway、Panama、Poland、Portugal、Russian Federation、Singapore、South Africa、Spain、Sweden、Switzerland、Thailand、Turkey、United Kingdom、USA、Yugoslavia (1、2)、Alfuzosin hydrochloride。
阿夫唑嗪 是一种化工化合物，登记 CAS 号为 81403-80-7，分子式 C19H27N5O4（分子量 389.4）。
登记 CAS 号：81403-80-7
其分子式 C19H27N5O4 由 19 个碳、27 个氢、5 个氮、4 个氧 组成。
别名/同义词：阿夫唑嗪 · Alfuzosin
阿夫唑嗪 的 CAS 登记号为 81403-80-7。
分子式 C19H27N5O4，分子量 389.4。
别名/同义词：阿夫唑嗪、Alfuzosin。
登记用途：Uses: Medication: antihypertensive、Use (kg、approx.) in Germany (2009): >250、Consumption (g per capita、approx.) in Germany (2009): 0.00305、Calculated removal (%): 9.2、Formulations、Preparations: Oral: Tablets、extended-release 10 mg Uroxatral (with povidone)、(Sanofi-Synthelabo).、Uroxatral、General Manufacturing Information: Preparation: P.M.J. Manoury、DE 2904445、idem、US 4315007 (1979、1982 both to Synthelabo)、Information available in 2004 indicated that Alfuzosin was used in the manufacture of pharmaceutical preparations in the following countries: Argentina、Romania、Information available in 2004 indicated that Alfuzosin hydrochloride was used in the manufacture of pharmaceutical preparations in the following countries: Algeria、Argentina、Austria、Belgium、Brazil、Canada、Chile、Colombia、Costa Rica、Czech Republic、Denmark、Dominican Republic、Ecuador、El Salvador、Finland、France、Germany、Greece、Guatemala、Honduras、Hong Kong、Hungary、Ireland、Israel、Italy、Luxembourg、Malaysia、Netherlands、Nicaragua、Norway、Panama、Poland、Portugal、Russian Federation、Singapore、South Africa、Spain、Sweden、Switzerland、Thailand、Turkey、United Kingdom、USA、Yugoslavia (1、2)、Alfuzosin hydrochloride。
阿夫唑嗪（CAS 81403-80-7）的独立参考数据，整理自公开化学数据库。
| CAS Registry Number | 81403-80-7 |
|---|---|
| PubChem CID | 2092 |
| Molecular formula | C19H27N5O4 |
| IUPAC name | N-[3-[(4-amino-6,7-dimethoxyquinazolin-2-yl)-methylamino]propyl]oxolane-2-carboxamide |
| UNII (FDA) | 90347YTW5F |
| Molecular Weight | 389.4 |
|---|---|
| XLogP3 | 1.7 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 8 |
| Rotatable Bond Count | 8 |
| Exact Mass | 389.20630436 |
| Monoisotopic Mass | 389.20630436 |
| Topological Polar Surface Area | 112 |
| Heavy Atom Count | 28 |
| Boiling Point | 688 |
|---|---|
| Melting Point | 240 |
| Solubility | 2.82e-01 g/L |
| LogP | 1.604 |
| LogP | 1.4 |
| LogP | 1.93 |
| Dissociation Constants | 8.13 |
| Dissociation Constants | pKa = 8.13 |
alfuzosin; 81403-80-7; Alfuzosina; Alfuzosine; Alfuzosinum; NSC-760065; N-{3-[(4-amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino]propyl}oxolane-2-carboxamide; 90347YTW5F; N-(3-((4-Amino-6,7-dimethoxy-2-quinazolinyl)methylamino)propyl)tetrahydro-2-furancarboxamide; DTXSID6048549; CHEBI:51141; alphuzosine; N-[3-[(4-amino-6,7-dimethoxy-2-quinazolinyl)methylamino]propyl]tetrahydro-2-furancarboxamide; alfusozine; N-(3-((4-amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)oxolane-2-carboxamide; N-(3-((4-imino-6,7-dimethoxy-3,4-dihydroquinazolin-2-yl)(methyl)amino)propyl)oxolane-2-carboximidic acid
| Reported hazard statements | H373 (100%) |
|---|
H373 (100%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]
P260, P319, and P501 (click each P-code to see the statement)
Alfuzosin · CAS 81403-80-7 · C19H27N5O4. UNII 90347YTW5F. Boiling Point: 688; Melting Point: 240; Solubility: 2.82e-01 g/L.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: Alfuzosin