依地酸二钠(CAS 139-33-3):分子式 C10H16N2O8、分子量 292.24;类别 医药中间体及原料药。
| CAS号 | 139-33-3 |
|---|---|
| 分子式 | C10H16N2O8 |
| 分子量 | 292.24 |
| 熔点 | 237 |
| LogP | -2.6 |
| 应用领域 | Uses: CIR ingredient: Disodium EDTA、Formerly registered in the US for use as a disinfectant and component of contact lens solutions、[NPIRS] Used as a preservative、color retention agent、antioxidant、flavoring agent for foods、anticoagulant for blood collection、and chelating agent in personal care products、Also used in the pulp and paper industry、in laboratory titrimetric analysis of metals、and as a therapeutic chelating agent、[Merck Index] Used in the agricultural、paper-pulp-board、textile processing、detergent、and cosmetics industries、Used as a cleaning、washing agent、disinfectant、coloring agent、complexing agent、stabilizer、and micro-nutrient、[IUCLID]、Pulp and Paper Processing [Category: Industry]、Using Disinfectants or Biocides [Category: Clean]、Textiles (Printing、Dyeing、or Finishing) [Category: Industry]、For disodium EDTA (USEPA、OPP Pesticide Code: 039115) there are 0 labels match.、SRP: Not registered for current use in the U.S.、but approved pesticide uses may change periodically and so federal、state and local authorities must be consulted for currently approved uses.、The active ingredient is no longer contained in any registered products ... "cancelled."、Disodium EDTA is a preservative、sequestrant、and stabilizer ... Disodium EDTA is permitted in the feed and drinking water of animals and、or for the treatment of food-producing animals. ... Disodium EDTA is not expected to contain preservatives、antioxidants、or sequestering agents for the purposes of stabilization.、Prevent discoloration due to trace metals in antibiotics、antihistamines、and local anesthetics. They are used to stabilize solutions of ascorbic acid (vitamin C)、hydrogen peroxide、formaldehyde、folic acid、and hyaluronidase and are used to increase antibacterial activity of components of ophthalmic and contact lens care solutions.、For more Uses (Complete) data for Disodium EDTA (7 total)、please visit the HSDB record page.、Use Classification: Fragrance Ingredients、Food Additives -> ANTIOXIDANT_SYNERGIST、PRESERVATIVE、SEQUESTRANT、SYNERGIST -> JECFA Functional Classes、Cosmetics -> Viscosity controlling、Chelating、Industry Uses: CBI、Chelating agent、Ion exchange agent、Consumer Uses: Chelating agent、Household Products: Information on 1150 consumer products that contain Disodium EDTA in the following categories is provided:、• Auto Products、• Inside the Home、• Personal Care、• Pet Care、Methods of Manufacturing: All of the industrially used methods of manufacture of EDTA and its salts involve the addition of formaldehyde and hydrogen cyanide or an alkali metal cyanide to an aqueous solution of EDTA. The salts、or edetates、are then formed by hydrolysis. EDTA can also be formed by heating tetrahydroxyethylethylenediamine with sodium or potassium hydroxide using a cadmium oxide catalyst. Disodium EDTA was prepared by dissolving EDTA into a hot solution that contained two equivalents of sodium hydroxide. The solution was then allowed to crystallize.、(Ethylenedinitrilo)tetraacetic acid is dissolved in a hot solution containing two equivalents of NaOH、and the disodium salt is allowed to crystallize.、Impurities: Disodium EDTA is not expected to contain pesticides、1、4-dioxane、free ethylene oxide、monochloroacetic acid、sulfite、organic solvents、nitrosamines、or other substances. The maximum concentration of heavy metals and formaldehyde is 10 ppm and 100 ppm、respectively.、Formulations、Preparations: Disodium EDTA is a substituted diamine ... it contains 76.0% to 77.5% EDTA. When dried、the cosmetic-grade material contains not less than 99.0% of Disodium EDTA ... The pharmaceutical-grade material contains not less than 99.0% and not more than 101.0%、disodium EDTA、calculated on a dried basis.、Endrate (Edetate Disodium Injection、USP) is supplied in 20 mL (3 g) ampuls、U.S. Production: 2023: 4、000、000 - <5、500、000 lb、2022: 2、000 - <4、2021: 4、2020: 4、Glycine、N、N'-1、2-ethanediylbis[N-(carboxymethyl)-、disodium salt is listed as a High Production Volume (HPV) chemical (65FR81686). Chemicals listed as HPV were produced in or imported into the U.S. in >1 million pounds in 1990 and、or 1994. The HPV list is based on the 1990 Inventory Update Rule. (IUR) (40 CFR part 710 subpart B、51FR21438).[EPA、Office of Pollution Prevention and Toxics、High Production Volume (HPV) Challenge Program. Glycine、2-ethanediylbis、Production volumes for non-confidential chemicals reported under the Inventory Update Rule. [Table#7960]、[US EPA、Non-confidential Production Volume Information Submitted by Companies for Chemicals Under the 1986-2002 Inventory Update Rule (IUR). Glycine、Production volume for non-confidential chemicals reported under the 2006 Inventory Update Rule. Chemical: Glycine、sodium salt (1:2). Aggregated National Production Volume: 1 to < 10 million lbs.[US EPA、Non-Confidential 2006 Inventory Update Reporting. National Chemical Information. Glycine、General Manufacturing Information: Soap、Cleaning Compound、and Toilet Preparation Manufacturing、CBI、Pharmaceutical and Medicine Manufacturing、All Other Basic Organic Chemical Manufacturing、sodium salt (1:2): ACTIVE、Disodium edetate、Na2EDTA、and ... closely related compounds have been used as industrial and analytical reagents because they chelate many divalent & trivalent metals |
| 类别 | 药用辅料 |
登记用途:Uses: CIR ingredient: Disodium EDTA、Formerly registered in the US for use as a disinfectant and component of contact lens solutions、[NPIRS] Used as a preservative、color retention agent、antioxidant、flavoring agent for foods、anticoagulant for blood collection、and chelating agent in personal care products、Also used in the pulp and paper industry、in laboratory titrimetric analysis of metals、and as a therapeutic chelating agent、[Merck Index] Used in the agricultural、paper-pulp-board、textile processing、detergent、and cosmetics industries、Used as a cleaning、washing agent、disinfectant、coloring agent、complexing agent、stabilizer、and micro-nutrient、[IUCLID]、Pulp and Paper Processing [Category: Industry]、Using Disinfectants or Biocides [Category: Clean]、Textiles (Printing、Dyeing、or Finishing) [Category: Industry]、For disodium EDTA (USEPA、OPP Pesticide Code: 039115) there are 0 labels match.、SRP: Not registered for current use in the U.S.、but approved pesticide uses may change periodically and so federal、state and local authorities must be consulted for currently approved uses.、The active ingredient is no longer contained in any registered products ... "cancelled."、Disodium EDTA is a preservative、sequestrant、and stabilizer ... Disodium EDTA is permitted in the feed and drinking water of animals and、or for the treatment of food-producing animals. ... Disodium EDTA is not expected to contain preservatives、antioxidants、or sequestering agents for the purposes of stabilization.、Prevent discoloration due to trace metals in antibiotics、antihistamines、and local anesthetics. They are used to stabilize solutions of ascorbic acid (vitamin C)、hydrogen peroxide、formaldehyde、folic acid、and hyaluronidase and are used to increase antibacterial activity of components of ophthalmic and contact lens care solutions.、For more Uses (Complete) data for Disodium EDTA (7 total)、please visit the HSDB record page.、Use Classification: Fragrance Ingredients、Food Additives -> ANTIOXIDANT_SYNERGIST、PRESERVATIVE、SEQUESTRANT、SYNERGIST -> JECFA Functional Classes、Cosmetics -> Viscosity controlling、Chelating、Industry Uses: CBI、Chelating agent、Ion exchange agent、Consumer Uses: Chelating agent、Household Products: Information on 1150 consumer products that contain Disodium EDTA in the following categories is provided:、• Auto Products、• Inside the Home、• Personal Care、• Pet Care、Methods of Manufacturing: All of the industrially used methods of manufacture of EDTA and its salts involve the addition of formaldehyde and hydrogen cyanide or an alkali metal cyanide to an aqueous solution of EDTA. The salts、or edetates、are then formed by hydrolysis. EDTA can also be formed by heating tetrahydroxyethylethylenediamine with sodium or potassium hydroxide using a cadmium oxide catalyst. Disodium EDTA was prepared by dissolving EDTA into a hot solution that contained two equivalents of sodium hydroxide. The solution was then allowed to crystallize.、(Ethylenedinitrilo)tetraacetic acid is dissolved in a hot solution containing two equivalents of NaOH、and the disodium salt is allowed to crystallize.、Impurities: Disodium EDTA is not expected to contain pesticides、1、4-dioxane、free ethylene oxide、monochloroacetic acid、sulfite、organic solvents、nitrosamines、or other substances. The maximum concentration of heavy metals and formaldehyde is 10 ppm and 100 ppm、respectively.、Formulations、Preparations: Disodium EDTA is a substituted diamine ... it contains 76.0% to 77.5% EDTA. When dried、the cosmetic-grade material contains not less than 99.0% of Disodium EDTA ... The pharmaceutical-grade material contains not less than 99.0% and not more than 101.0%、disodium EDTA、calculated on a dried basis.、Endrate (Edetate Disodium Injection、USP) is supplied in 20 mL (3 g) ampuls、U.S. Production: 2023: 4、000、000 - <5、500、000 lb、2022: 2、000 - <4、2021: 4、2020: 4、Glycine、N、N'-1、2-ethanediylbis[N-(carboxymethyl)-、disodium salt is listed as a High Production Volume (HPV) chemical (65FR81686). Chemicals listed as HPV were produced in or imported into the U.S. in >1 million pounds in 1990 and、or 1994. The HPV list is based on the 1990 Inventory Update Rule. (IUR) (40 CFR part 710 subpart B、51FR21438).[EPA、Office of Pollution Prevention and Toxics、High Production Volume (HPV) Challenge Program. Glycine、2-ethanediylbis、Production volumes for non-confidential chemicals reported under the Inventory Update Rule. [Table#7960]、[US EPA、Non-confidential Production Volume Information Submitted by Companies for Chemicals Under the 1986-2002 Inventory Update Rule (IUR). Glycine、Production volume for non-confidential chemicals reported under the 2006 Inventory Update Rule. Chemical: Glycine、sodium salt (1:2). Aggregated National Production Volume: 1 to < 10 million lbs.[US EPA、Non-Confidential 2006 Inventory Update Reporting. National Chemical Information. Glycine、General Manufacturing Information: Soap、Cleaning Compound、and Toilet Preparation Manufacturing、CBI、Pharmaceutical and Medicine Manufacturing、All Other Basic Organic Chemical Manufacturing、sodium salt (1:2): ACTIVE、Disodium edetate、Na2EDTA、and ... closely related compounds have been used as industrial and analytical reagents because they chelate many divalent & trivalent metals。
依地酸二钠 是一种医药中间体或原料药类化合物,登记 CAS 号为 139-33-3,分子式 C10H16N2O8(分子量 292.24),归属于医药中间体及原料药大类化工原料。
登记 CAS 号:139-33-3
其分子式 C10H16N2O8 由 10 个碳、16 个氢、2 个氮、8 个氧 组成。
别名/同义词:依地酸二钠 · Ethylenediaminetetraacetic acid disodium salt · Edetate Disodium
所属分类:医药中间体及原料药
依地酸二钠 的 CAS 登记号为 139-33-3。
分子式 C10H16N2O8,分子量 292.24。
别名/同义词:依地酸二钠、Ethylenediaminetetraacetic acid disodium salt、Edetate Disodium。
登记用途:Uses: CIR ingredient: Disodium EDTA、Formerly registered in the US for use as a disinfectant and component of contact lens solutions、[NPIRS] Used as a preservative、color retention agent、antioxidant、flavoring agent for foods、anticoagulant for blood collection、and chelating agent in personal care products、Also used in the pulp and paper industry、in laboratory titrimetric analysis of metals、and as a therapeutic chelating agent、[Merck Index] Used in the agricultural、paper-pulp-board、textile processing、detergent、and cosmetics industries、Used as a cleaning、washing agent、disinfectant、coloring agent、complexing agent、stabilizer、and micro-nutrient、[IUCLID]、Pulp and Paper Processing [Category: Industry]、Using Disinfectants or Biocides [Category: Clean]、Textiles (Printing、Dyeing、or Finishing) [Category: Industry]、For disodium EDTA (USEPA、OPP Pesticide Code: 039115) there are 0 labels match.、SRP: Not registered for current use in the U.S.、but approved pesticide uses may change periodically and so federal、state and local authorities must be consulted for currently approved uses.、The active ingredient is no longer contained in any registered products ... "cancelled."、Disodium EDTA is a preservative、sequestrant、and stabilizer ... Disodium EDTA is permitted in the feed and drinking water of animals and、or for the treatment of food-producing animals. ... Disodium EDTA is not expected to contain preservatives、antioxidants、or sequestering agents for the purposes of stabilization.、Prevent discoloration due to trace metals in antibiotics、antihistamines、and local anesthetics. They are used to stabilize solutions of ascorbic acid (vitamin C)、hydrogen peroxide、formaldehyde、folic acid、and hyaluronidase and are used to increase antibacterial activity of components of ophthalmic and contact lens care solutions.、For more Uses (Complete) data for Disodium EDTA (7 total)、please visit the HSDB record page.、Use Classification: Fragrance Ingredients、Food Additives -> ANTIOXIDANT_SYNERGIST、PRESERVATIVE、SEQUESTRANT、SYNERGIST -> JECFA Functional Classes、Cosmetics -> Viscosity controlling、Chelating、Industry Uses: CBI、Chelating agent、Ion exchange agent、Consumer Uses: Chelating agent、Household Products: Information on 1150 consumer products that contain Disodium EDTA in the following categories is provided:、• Auto Products、• Inside the Home、• Personal Care、• Pet Care、Methods of Manufacturing: All of the industrially used methods of manufacture of EDTA and its salts involve the addition of formaldehyde and hydrogen cyanide or an alkali metal cyanide to an aqueous solution of EDTA. The salts、or edetates、are then formed by hydrolysis. EDTA can also be formed by heating tetrahydroxyethylethylenediamine with sodium or potassium hydroxide using a cadmium oxide catalyst. Disodium EDTA was prepared by dissolving EDTA into a hot solution that contained two equivalents of sodium hydroxide. The solution was then allowed to crystallize.、(Ethylenedinitrilo)tetraacetic acid is dissolved in a hot solution containing two equivalents of NaOH、and the disodium salt is allowed to crystallize.、Impurities: Disodium EDTA is not expected to contain pesticides、1、4-dioxane、free ethylene oxide、monochloroacetic acid、sulfite、organic solvents、nitrosamines、or other substances. The maximum concentration of heavy metals and formaldehyde is 10 ppm and 100 ppm、respectively.、Formulations、Preparations: Disodium EDTA is a substituted diamine ... it contains 76.0% to 77.5% EDTA. When dried、the cosmetic-grade material contains not less than 99.0% of Disodium EDTA ... The pharmaceutical-grade material contains not less than 99.0% and not more than 101.0%、disodium EDTA、calculated on a dried basis.、Endrate (Edetate Disodium Injection、USP) is supplied in 20 mL (3 g) ampuls、U.S. Production: 2023: 4、000、000 - <5、500、000 lb、2022: 2、000 - <4、2021: 4、2020: 4、Glycine、N、N'-1、2-ethanediylbis[N-(carboxymethyl)-、disodium salt is listed as a High Production Volume (HPV) chemical (65FR81686). Chemicals listed as HPV were produced in or imported into the U.S. in >1 million pounds in 1990 and、or 1994. The HPV list is based on the 1990 Inventory Update Rule. (IUR) (40 CFR part 710 subpart B、51FR21438).[EPA、Office of Pollution Prevention and Toxics、High Production Volume (HPV) Challenge Program. Glycine、2-ethanediylbis、Production volumes for non-confidential chemicals reported under the Inventory Update Rule. [Table#7960]、[US EPA、Non-confidential Production Volume Information Submitted by Companies for Chemicals Under the 1986-2002 Inventory Update Rule (IUR). Glycine、Production volume for non-confidential chemicals reported under the 2006 Inventory Update Rule. Chemical: Glycine、sodium salt (1:2). Aggregated National Production Volume: 1 to < 10 million lbs.[US EPA、Non-Confidential 2006 Inventory Update Reporting. National Chemical Information. Glycine、General Manufacturing Information: Soap、Cleaning Compound、and Toilet Preparation Manufacturing、CBI、Pharmaceutical and Medicine Manufacturing、All Other Basic Organic Chemical Manufacturing、sodium salt (1:2): ACTIVE、Disodium edetate、Na2EDTA、and ... closely related compounds have been used as industrial and analytical reagents because they chelate many divalent & trivalent metals。
所属分类:药用辅料。
依地酸二钠(CAS 139-33-3)的独立参考数据,整理自公开化学数据库。
| CAS 号 | 139-33-3 |
|---|---|
| PubChem CID | 8759 |
| 分子式 | C10H14N2Na2O8 |
| 分子量 | 336.06 g/mol |
| IUPAC 名称 | disodium;2-[2-[carboxylatomethyl(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetate |
| InChIKey | ZGTMUACCHSMWAC-UHFFFAOYSA-L |
| UNII(FDA) | 8NLQ36F6MM |
| ChEBI 编号 | CHEBI:64734 |
| Molecular Weight | 336.21 |
|---|---|
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 10 |
| Rotatable Bond Count | 9 |
| Exact Mass | 336.05455397 |
| Monoisotopic Mass | 336.05455397 |
| Topological Polar Surface Area | 161 |
| Heavy Atom Count | 22 |
| Color Additive Status | 73.1 |
|---|---|
| Color Additive Status | 172.120 |
| Color Additive Status | 172.135 |
| Color Additive Status | 176.150 |
| Color Additive Status | 178.3570 |
| Color Additive Status | 178.1010 |
| Color Additive Status | 175.105 |
| Color Additive Status | 177.1200 |
139-33-3; EDTA disodium salt; Disodium EDTA; Edta disodium; Titriplex III; Disodium edta, anhydrous; Disodium ethylenediaminetetraacetate; Endrate disodium; Edetic Acid, Disodium Salt; Ethylenediaminetetraacetic acid, disodium salt; Disodium (ethylenedinitrilo)tetraacetate; EDTA-Na2; EDTA disodium salt (anhydrous); Endrate (TN); MFCD00070672; Disodium edathamil
| 法规与食品接触 | FDA Regulatory Status of Color Additives: Foods, Drugs ANTIOXIDANT_SYNERGIST; PRESERVATIVE; SEQUESTRANT; SYNERGIST: Food Additives JECFA ADI: 0-2.5 mg/kg bw 作为EDTA二钠钙;食品中不会残留过量的 EDTA 二钠 NMRS 53/TRS 539-JECFA 17/18 FAS 5/NMRS 53A-JECFA 17/173 |
|---|
乙二胺四乙酸二钠 的 CAS 号为 139-33-3,分子式 C10H14N2Na2O8,分子量 336.06 g/mol。 UNII 8NLQ36F6MM; ChEBI 64734; InChIKey ZGTMUACCHSMWAC-UHFFFAOYSA-L. Color Additive Status: 73.1; Color Additive Status: 172.120; Color Additive Status: 172.135.
数据来源:PubChem / Wikidata;与随货 COA 不一致时以 COA 为准。
English page: Ethylenediaminetetraacetic acid disodium salt