Phenylephrine

Phenylephrine (CAS 59-42-7) — formula C9H13NO2, molecular weight 167.20; category organic chemicals.

Product Overview

Applications

Documented applications: Uses: Sympathomimetic vasoconstructor amine ... used for nasal congestion, Hydrochloride, ... used to dilate the pupil both for ophthalmoscopy in the treatment of uveitis and for cataract surgery, MEDICATION, THERAP CAT: Mydriatic, decongestant, in treatment of fecal incontinence., Use (kg, approx.) in Germany (2009): >100, Consumption (g per capita, approx.) in Germany (2009): 0.00122, Calculated removal (%): 92.1, Methods of Manufacturing: REACTION OF M-HYDROXYPHENACYL BROMIDE WITH METHYLAMINE FOLLOWED BY CATALYTIC HYDROGENATION, THEN DISSOLUTION IN ETHER, AND TREATMENT WITH HYDROGEN CHLORIDE, Preparation: H. Legerlotz, US 1932347 (1933 to Frederick Stearns), M-HYDROXYPHENACYL BROMIDE IS CONDENSED WITH METHYLAMINE VIA DEHYDROBROMINATION & CARBONYL GROUP IS THEN REDUCED TO CARBINOL VIA CATALYTIC HYDROGENATION. PHENYLEPHRINE SO FORMED IS DISSOLVED IN SUITABLE SOLVENT SUCH AS ETHER & TREATED WITH HYDROGEN CHLORIDE., PHENYLEPHRINE HYDROCHLORIDE, Formulations, Preparations: Oral: Strips, orally dissolving: 1.25 mg Triaminic Infant Thin Strips Decongestant, (Novartis) 2.5 mg Triaminic Thin Strips Cold, (Novartis). Tablets: 10 mg Sudafed PE, (Pfizer). Parenteral: Injection: 10 mg, mL Neo-Synephrine Hydrochloride (with sodium metabisulfite), (Sanofi-Aventis), Phenylephrine Hydrochloride Injection, (American Regent), (Baxter). Topical: Cream: 0.25% with Glycerin 12%, (Petrolatum), 18%, and Shark Liver Oil 3% Preparation H (with cetyl alcohol, methylparaben, and stearyl alcohol), (Wyeth). Gel: 0.25% with Witch Hazel 50% Preparation H (with methylparaben and propylparaben), (Wyeth). Ointment: 0.25% with Mineral Oil 14%, Petrolatum 71.9%, and Shark Liver Oil 3% Preparation H (with methylparaben and propylparaben), (Wyeth). Suppository: 0.25% with Cocoa Butter 85.5% and Shark Liver Oil 3% Preparation H (with methylparaben and propylparaben), (Wyeth)., Nasal: Solution: 0.25% Neo-Synephrine Mild Formula Spray (with benzalkonium chloride), (Bayer), 0.5% Neo-Synephrine Regular Strength (with benzalkonium chloride, drops and spray), Vicks Sinex for Sinus Relief (with benzalkonium chloride, regular or metered pump mist spray), (Procter & Gamble), 1% Neo-Synephrine Extra Strength (with benzalkonium chloride, (Bayer). Ophthalmic: Solution: 0.12% Ocu-Phrin, Ocumed Relief (with benzalkonium chloride), (Allergan), 2.5% AK-Dilate (with benzalkonium chloride and sodium bisulfite), (Akorn), Mydfrin (with benzalkonium chloride and sodium bisulfite), (Alcon) Neo-Synephrine Hydrochloride (with benzalkonium chloride), Ocu-Phrin, (Ocumed), 10% AK-Dilate (with benzalkonium chloride and sodium bisulfite), Neo-Synephrine Hydrochloride (with benzalkonium chloride, plain and viscous), (Ocumed). Parenteral: Injection: 10 mg, (Baxter)., Phenylephrine hydrochloride, Ophthalmic: Solution: 0.12% Ocu-Phrin, Relief (with benzalkonium chloride, viscous), (Alcon), Neo-Synephrine Hydrochloride (with benzalkonium chloride), Phenylephrine Hydrochloride Ophthalmic Solution, (Bausch & Lomb), (Falcon), (Ocumed)., U.S. Production: (1976) PROBABLY GREATER THAN 9.08X10+5 G, (1978) PROBABLY GREATER THAN 9.08X10+5 G, (1988) No data published for phenylephrine (bitartrate, hydrochloride, tannate), U.S. Imports: (1976) 1.30X10+6 G (PRINCPL CUSTMS DISTS), (1978) 4.43X10+6 G (PRINCPL CUSTMS DISTS).

Technical Profile

What this product is

Phenylephrine is a carbon-based organic compound with CAS registry number 59-42-7 and molecular formula C9H13NO2 (molecular weight 167.20), belonging to the organic chemicals segment of chemical raw materials.

Identification

CAS number: 59-42-7

Its molecular formula C9H13NO2 comprises 9 C, 13 H, 1 N, 2 O atoms.

Also known as: Phenylephrine · 去氧肾上腺素

Category: organic chemicals

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