(-)-Hygroton（CAS 74658-80-3）：分子式 C14H11ClN2O4S、分子量 338.8。
| CAS号 | 74658-80-3 |
|---|---|
| 分子式 | C14H11ClN2O4S |
| 分子量 | 338.8 |
| 熔点 | 239 |
| LogP | 0.85 |
| 应用领域 | Uses: Therap cat (Vet): Diuretic、Therap cat: Diuretic、antihypertensive、... is indicated in the management of hypertension either alone or in combination with other antihypertensive drugs. Chlorthalidone is indicated as adjunctive therapy in edema associated with congestive heart failure、hepatic cirrhosis、and corticosteriod and estrogen therapy.、MEDICATION、Use (kg、approx.) in Germany (2009): >500、Use (kg) in USA (2002): 1380、Consumption (g per capita、approx.) in Germany (2009): 0.00611、Consumption (g per capita) in the USA (2002): 0.00489、Calculated removal (%): 8.8、Use Classification: Pharmaceuticals、Methods of Manufacturing: DIAZOTIZATION OF 3-AMINO-4-CHLOROBENZOPHENONE-2-CARBOXYLIC ACID、FOLLOWED BY REACTION WITH SULFUR DIOXIDE、THEN THIONYL CHLORIDE AND AMMONIA、Graf et al、Helv Chim Acta 42、1085 (1959)、US patent 3、055、904 (1962 to Geigy).、HEATING...4-CHLORO-2'-CARBOXYBENZOPHENONE-3-SULFONYL CHLORIDE WITH THIONYL CHLORIDE YIELDS 3-CHLORO-3-(3'-CHLOR OSULFONYL-4'-CHLOROPHENYL)PHTHALIDE WHICH IS ISOLATED、DISSOLVED IN CHLOROFORM、& REACTED WITH AMMONIA...IN...ETHANOL. REMOVAL OF SOLVENT & TREATMENT OF RESIDUE WITH HCL YIELDS CRUDE CHLORTHALIDONE...、Formulations、Preparations: DOSAGE FORMS--TABLETS USP: 50 & 100 MG.、15 or 25 mg tablets for oral use.、Usual dosage range: 12.5 to 50 mg、d.、Clinical doses range from 25 to 400 mg.、U.S. Production: (1975) PROBABLY GREATER THAN 4.54X10+5 GRAMS、(1976) PROBABLY GREATER THAN 4.54X10+5 GRAMS、Fine chemical: $100、kg、100 tons、year、Specialty chemical: $1000、yr、U.S. Imports: (1977) 4.33X10+6 GRAMS (PRINCPL CUSTMS DISTS)、(1979) 7.15X10+7 GRAMS (PRINCPL CUSTMS DISTS) |
登记用途：Uses: Therap cat (Vet): Diuretic、Therap cat: Diuretic、antihypertensive、... is indicated in the management of hypertension either alone or in combination with other antihypertensive drugs. Chlorthalidone is indicated as adjunctive therapy in edema associated with congestive heart failure、hepatic cirrhosis、and corticosteriod and estrogen therapy.、MEDICATION、Use (kg、approx.) in Germany (2009): >500、Use (kg) in USA (2002): 1380、Consumption (g per capita、approx.) in Germany (2009): 0.00611、Consumption (g per capita) in the USA (2002): 0.00489、Calculated removal (%): 8.8、Use Classification: Pharmaceuticals、Methods of Manufacturing: DIAZOTIZATION OF 3-AMINO-4-CHLOROBENZOPHENONE-2-CARBOXYLIC ACID、FOLLOWED BY REACTION WITH SULFUR DIOXIDE、THEN THIONYL CHLORIDE AND AMMONIA、Graf et al、Helv Chim Acta 42、1085 (1959)、US patent 3、055、904 (1962 to Geigy).、HEATING...4-CHLORO-2'-CARBOXYBENZOPHENONE-3-SULFONYL CHLORIDE WITH THIONYL CHLORIDE YIELDS 3-CHLORO-3-(3'-CHLOR OSULFONYL-4'-CHLOROPHENYL)PHTHALIDE WHICH IS ISOLATED、DISSOLVED IN CHLOROFORM、& REACTED WITH AMMONIA...IN...ETHANOL. REMOVAL OF SOLVENT & TREATMENT OF RESIDUE WITH HCL YIELDS CRUDE CHLORTHALIDONE...、Formulations、Preparations: DOSAGE FORMS--TABLETS USP: 50 & 100 MG.、15 or 25 mg tablets for oral use.、Usual dosage range: 12.5 to 50 mg、d.、Clinical doses range from 25 to 400 mg.、U.S. Production: (1975) PROBABLY GREATER THAN 4.54X10+5 GRAMS、(1976) PROBABLY GREATER THAN 4.54X10+5 GRAMS、Fine chemical: $100、kg、100 tons、year、Specialty chemical: $1000、yr、U.S. Imports: (1977) 4.33X10+6 GRAMS (PRINCPL CUSTMS DISTS)、(1979) 7.15X10+7 GRAMS (PRINCPL CUSTMS DISTS)。
(-)-Hygroton 是一种化工化合物，登记 CAS 号为 74658-80-3，分子式 C14H11ClN2O4S（分子量 338.8）。
登记 CAS 号：74658-80-3
其分子式 C14H11ClN2O4S 由 14 个碳、11 个氢、1 个氯、2 个氮、4 个氧、1 个硫 组成。
别名/同义词：(-)-Hygroton
(-)-Hygroton 的 CAS 登记号为 74658-80-3。
分子式 C14H11ClN2O4S，分子量 338.8。
别名/同义词：(-)-Hygroton。
登记用途：Uses: Therap cat (Vet): Diuretic、Therap cat: Diuretic、antihypertensive、... is indicated in the management of hypertension either alone or in combination with other antihypertensive drugs. Chlorthalidone is indicated as adjunctive therapy in edema associated with congestive heart failure、hepatic cirrhosis、and corticosteriod and estrogen therapy.、MEDICATION、Use (kg、approx.) in Germany (2009): >500、Use (kg) in USA (2002): 1380、Consumption (g per capita、approx.) in Germany (2009): 0.00611、Consumption (g per capita) in the USA (2002): 0.00489、Calculated removal (%): 8.8、Use Classification: Pharmaceuticals、Methods of Manufacturing: DIAZOTIZATION OF 3-AMINO-4-CHLOROBENZOPHENONE-2-CARBOXYLIC ACID、FOLLOWED BY REACTION WITH SULFUR DIOXIDE、THEN THIONYL CHLORIDE AND AMMONIA、Graf et al、Helv Chim Acta 42、1085 (1959)、US patent 3、055、904 (1962 to Geigy).、HEATING...4-CHLORO-2'-CARBOXYBENZOPHENONE-3-SULFONYL CHLORIDE WITH THIONYL CHLORIDE YIELDS 3-CHLORO-3-(3'-CHLOR OSULFONYL-4'-CHLOROPHENYL)PHTHALIDE WHICH IS ISOLATED、DISSOLVED IN CHLOROFORM、& REACTED WITH AMMONIA...IN...ETHANOL. REMOVAL OF SOLVENT & TREATMENT OF RESIDUE WITH HCL YIELDS CRUDE CHLORTHALIDONE...、Formulations、Preparations: DOSAGE FORMS--TABLETS USP: 50 & 100 MG.、15 or 25 mg tablets for oral use.、Usual dosage range: 12.5 to 50 mg、d.、Clinical doses range from 25 to 400 mg.、U.S. Production: (1975) PROBABLY GREATER THAN 4.54X10+5 GRAMS、(1976) PROBABLY GREATER THAN 4.54X10+5 GRAMS、Fine chemical: $100、kg、100 tons、year、Specialty chemical: $1000、yr、U.S. Imports: (1977) 4.33X10+6 GRAMS (PRINCPL CUSTMS DISTS)、(1979) 7.15X10+7 GRAMS (PRINCPL CUSTMS DISTS)。
(-)-Hygroton（CAS 74658-80-3）的独立参考数据，整理自公开化学数据库。
| CAS 号 | 74658-80-3 |
|---|---|
| PubChem CID | 2732 |
| 分子式 | C14H11ClN2O4S |
| IUPAC 名称 | 2-chloro-5-(1-hydroxy-3-oxo-2H-isoindol-1-yl)benzenesulfonamide |
| UNII（FDA） | Q0MQD1073Q |
| Molecular Weight | 338.8 |
|---|---|
| XLogP3 | 0.9 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 2 |
| Exact Mass | 338.0128057 |
| Monoisotopic Mass | 338.0128057 |
| Topological Polar Surface Area | 118 |
| Heavy Atom Count | 22 |
| Melting Point | 239 |
|---|---|
| Melting Point | 218 - 264 °C |
| Solubility | 120 |
| Solubility | 5.28e-02 g/L |
| LogP | 0.85 |
| LogP | log Kow= 0.85 |
| LogP | 1.3 |
| LogP | 1.17 |
chlorthalidone; 77-36-1; Chlortalidone; Phthalamudine; Hygroton; Chlorphthalidolone; Chlorthalidon; Phthalamodine; Natriuran; Thalitone; Chlorothalidone; Chlorphthalidone; Saluretin; Igroton; Zambesil; Isoren
| GHS 通报统计 | 38.7% (41 / 106) |
|---|
| GHS 通报统计 | 38.7% (41 / 106) |
|---|---|
| 已通报的危害声明 | H315 (58.5%), H319 (59.4%), H335 (57.5%) |
(-)-Hygroton · CAS 74658-80-3 · C14H11ClN2O4S. UNII Q0MQD1073Q. Melting Point: 239; Melting Point: 218 - 264 °C; Solubility: 120.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: (-)-Hygroton