(-)-Hygroton (CAS 74658-80-3) — formula C14H11ClN2O4S, molecular weight 338.8; category organic chemicals.
| CAS Number | 74658-80-3 |
|---|---|
| Molecular Formula | C14H11ClN2O4S |
| Molecular Weight | 338.8 |
| Melting Point | 239 |
| LogP | 0.85 |
| Applications | Uses: Therap cat (Vet): Diuretic, Therap cat: Diuretic, antihypertensive, ... is indicated in the management of hypertension either alone or in combination with other antihypertensive drugs. Chlorthalidone is indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteriod and estrogen therapy., MEDICATION, Use (kg, approx.) in Germany (2009): >500, Use (kg) in USA (2002): 1380, Consumption (g per capita, approx.) in Germany (2009): 0.00611, Consumption (g per capita) in the USA (2002): 0.00489, Calculated removal (%): 8.8, Use Classification: Pharmaceuticals, Methods of Manufacturing: DIAZOTIZATION OF 3-AMINO-4-CHLOROBENZOPHENONE-2-CARBOXYLIC ACID, FOLLOWED BY REACTION WITH SULFUR DIOXIDE, THEN THIONYL CHLORIDE AND AMMONIA, Graf et al, Helv Chim Acta 42, 1085 (1959), US patent 3, 055, 904 (1962 to Geigy)., HEATING...4-CHLORO-2'-CARBOXYBENZOPHENONE-3-SULFONYL CHLORIDE WITH THIONYL CHLORIDE YIELDS 3-CHLORO-3-(3'-CHLOR OSULFONYL-4'-CHLOROPHENYL)PHTHALIDE WHICH IS ISOLATED, DISSOLVED IN CHLOROFORM, & REACTED WITH AMMONIA...IN...ETHANOL. REMOVAL OF SOLVENT & TREATMENT OF RESIDUE WITH HCL YIELDS CRUDE CHLORTHALIDONE..., Formulations, Preparations: DOSAGE FORMS--TABLETS USP: 50 & 100 MG., 15 or 25 mg tablets for oral use., Usual dosage range: 12.5 to 50 mg, d., Clinical doses range from 25 to 400 mg., U.S. Production: (1975) PROBABLY GREATER THAN 4.54X10+5 GRAMS, (1976) PROBABLY GREATER THAN 4.54X10+5 GRAMS, Fine chemical: $100, kg, 100 tons, year, Specialty chemical: $1000, yr, U.S. Imports: (1977) 4.33X10+6 GRAMS (PRINCPL CUSTMS DISTS), (1979) 7.15X10+7 GRAMS (PRINCPL CUSTMS DISTS) |
| Category | Organic Chemicals |
Documented applications: Uses: Therap cat (Vet): Diuretic, Therap cat: Diuretic, antihypertensive, ... is indicated in the management of hypertension either alone or in combination with other antihypertensive drugs. Chlorthalidone is indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteriod and estrogen therapy., MEDICATION, Use (kg, approx.) in Germany (2009): >500, Use (kg) in USA (2002): 1380, Consumption (g per capita, approx.) in Germany (2009): 0.00611, Consumption (g per capita) in the USA (2002): 0.00489, Calculated removal (%): 8.8, Use Classification: Pharmaceuticals, Methods of Manufacturing: DIAZOTIZATION OF 3-AMINO-4-CHLOROBENZOPHENONE-2-CARBOXYLIC ACID, FOLLOWED BY REACTION WITH SULFUR DIOXIDE, THEN THIONYL CHLORIDE AND AMMONIA, Graf et al, Helv Chim Acta 42, 1085 (1959), US patent 3, 055, 904 (1962 to Geigy)., HEATING...4-CHLORO-2'-CARBOXYBENZOPHENONE-3-SULFONYL CHLORIDE WITH THIONYL CHLORIDE YIELDS 3-CHLORO-3-(3'-CHLOR OSULFONYL-4'-CHLOROPHENYL)PHTHALIDE WHICH IS ISOLATED, DISSOLVED IN CHLOROFORM, & REACTED WITH AMMONIA...IN...ETHANOL. REMOVAL OF SOLVENT & TREATMENT OF RESIDUE WITH HCL YIELDS CRUDE CHLORTHALIDONE..., Formulations, Preparations: DOSAGE FORMS--TABLETS USP: 50 & 100 MG., 15 or 25 mg tablets for oral use., Usual dosage range: 12.5 to 50 mg, d., Clinical doses range from 25 to 400 mg., U.S. Production: (1975) PROBABLY GREATER THAN 4.54X10+5 GRAMS, (1976) PROBABLY GREATER THAN 4.54X10+5 GRAMS, Fine chemical: $100, kg, 100 tons, year, Specialty chemical: $1000, yr, U.S. Imports: (1977) 4.33X10+6 GRAMS (PRINCPL CUSTMS DISTS), (1979) 7.15X10+7 GRAMS (PRINCPL CUSTMS DISTS).
(-)-Hygroton is a carbon-based organic compound with CAS registry number 74658-80-3 and molecular formula C14H11ClN2O4S (molecular weight 338.8), belonging to the organic chemicals segment of chemical raw materials.
CAS number: 74658-80-3
Its molecular formula C14H11ClN2O4S comprises 14 C, 11 H, 1 Cl, 2 N, 4 O, 1 S atoms.
Also known as: (-)-Hygroton
Category: organic chemicals
The CAS registry number of (-)-Hygroton is 74658-80-3.
Molecular formula C14H11ClN2O4S, molecular weight 338.8.
It is also registered under: (-)-Hygroton.
Recorded applications: Uses: Therap cat (Vet): Diuretic, Therap cat: Diuretic, antihypertensive, ... is indicated in the management of hypertension either alone or in combination with other antihypertensive drugs. Chlorthalidone is indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteriod and estrogen therapy., MEDICATION, Use (kg, approx.) in Germany (2009): >500, Use (kg) in USA (2002): 1380, Consumption (g per capita, approx.) in Germany (2009): 0.00611, Consumption (g per capita) in the USA (2002): 0.00489, Calculated removal (%): 8.8, Use Classification: Pharmaceuticals, Methods of Manufacturing: DIAZOTIZATION OF 3-AMINO-4-CHLOROBENZOPHENONE-2-CARBOXYLIC ACID, FOLLOWED BY REACTION WITH SULFUR DIOXIDE, THEN THIONYL CHLORIDE AND AMMONIA, Graf et al, Helv Chim Acta 42, 1085 (1959), US patent 3, 055, 904 (1962 to Geigy)., HEATING...4-CHLORO-2'-CARBOXYBENZOPHENONE-3-SULFONYL CHLORIDE WITH THIONYL CHLORIDE YIELDS 3-CHLORO-3-(3'-CHLOR OSULFONYL-4'-CHLOROPHENYL)PHTHALIDE WHICH IS ISOLATED, DISSOLVED IN CHLOROFORM, & REACTED WITH AMMONIA...IN...ETHANOL. REMOVAL OF SOLVENT & TREATMENT OF RESIDUE WITH HCL YIELDS CRUDE CHLORTHALIDONE..., Formulations, Preparations: DOSAGE FORMS--TABLETS USP: 50 & 100 MG., 15 or 25 mg tablets for oral use., Usual dosage range: 12.5 to 50 mg, d., Clinical doses range from 25 to 400 mg., U.S. Production: (1975) PROBABLY GREATER THAN 4.54X10+5 GRAMS, (1976) PROBABLY GREATER THAN 4.54X10+5 GRAMS, Fine chemical: $100, kg, 100 tons, year, Specialty chemical: $1000, yr, U.S. Imports: (1977) 4.33X10+6 GRAMS (PRINCPL CUSTMS DISTS), (1979) 7.15X10+7 GRAMS (PRINCPL CUSTMS DISTS).
Category: Organic Chemicals.
Independent reference data for (-)-Hygroton (CAS 74658-80-3), compiled from public chemistry databases.
| CAS 号 | 74658-80-3 |
|---|---|
| PubChem CID | 2732 |
| 分子式 | C14H11ClN2O4S |
| IUPAC 名称 | 2-chloro-5-(1-hydroxy-3-oxo-2H-isoindol-1-yl)benzenesulfonamide |
| UNII（FDA） | Q0MQD1073Q |
| Molecular Weight | 338.8 |
|---|---|
| XLogP3 | 0.9 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 2 |
| Exact Mass | 338.0128057 |
| Monoisotopic Mass | 338.0128057 |
| Topological Polar Surface Area | 118 |
| Heavy Atom Count | 22 |
| Melting Point | 239 |
|---|---|
| Melting Point | 218 - 264 °C |
| Solubility | 120 |
| Solubility | 5.28e-02 g/L |
| LogP | 0.85 |
| LogP | log Kow= 0.85 |
| LogP | 1.3 |
| LogP | 1.17 |
chlorthalidone; 77-36-1; Chlortalidone; Phthalamudine; Hygroton; Chlorphthalidolone; Chlorthalidon; Phthalamodine; Natriuran; Thalitone; Chlorothalidone; Chlorphthalidone; Saluretin; Igroton; Zambesil; Isoren
| GHS 通报统计 | 38.7% (41 / 106) |
|---|
| GHS 通报统计 | 38.7% (41 / 106) |
|---|---|
| 已通报的危害声明 | H315 (58.5%), H319 (59.4%), H335 (57.5%) |
(-)-Hygroton · CAS 74658-80-3 · C14H11ClN2O4S. UNII Q0MQD1073Q. Melting Point: 239; Melting Point: 218 - 264 °C; Solubility: 120.
Source: PubChem / Wikidata; the batch COA governs where values differ.
Supplier: Jinan Shenghe Chemical Co., Ltd.
中文页面: (-)-Hygroton