L-[35S]蛋氨酸（CAS 3654-96-4）：分子式 C5H11NO2S、分子量 149.21。
L-[35S]METHIONINE（CAS 3654-96-4） 属于 Food Additives 类别，作为常用化工原料在对应应用领域稳定供应。济南圣和化工有限公司（Jinan Shenghe Chemical Co., Ltd.）长期批量供应 L-[35S]METHIONINE，每批随货提供 COA 与分析证书，支持按订单定制纯度与包装规格。 典型归类：Food Additives。
| CAS号 | 3654-96-4 |
|---|---|
| 分子式 | C5H11NO2S |
| 分子量 | 149.21 |
| 熔点 | 283 |
| 沸点 | 181 °C (decomposes) |
| LogP | -1.87 |
| 应用领域 | Uses: CIR ingredient: Methionine、An essential amino acid、Used therapeutically as an antidote for acetaminophen poisoning and a urinary acidifier、[Merck Index] Chelating agent for heavy metals、[ChemIDplus] Used as a flavoring agent and nutritional supplement for foods、[FDA] Used in pharmaceuticals、as a feed additive、for vegetable oil enrichment、and as single cell protein、[NTP] Permitted for use as an inert ingredient in non-food pesticide products、[EPA]、Farming (Feed Additives) [Category: Industry]、Feed additive、vegetable oil enrichment、single-cell protein、DL-Methionine、Nutrient、BIOLOGICAL ACTIVITIES: Anticataract、antidote (acteaminophen、paracetamol)、antieczemic、antihepatotic、antioxidant、antiparkinsonian、cancer-preventive、emetic、essential、glutathionigenic、heptoprotective、lioptropic、urine-acidifier、urine-deodorant、THERAPEUTIC CATEGORY: Hepatoprotectant、antidote (acetaminophen poisoning)、urinary acidifier、For more Uses (Complete) data for (L)-Methionine (6 total)、please visit the HSDB record page.、Use (kg、approx.) in Germany (2009): >25000、Consumption (g per capita、approx.) in Germany (2009): 0.305、Calculated removal (%): 92.1、Used for protein synthesis including the formation of SAMe、L-homocysteine、L-cysteine、taurine、and sulfate.、Use Classification: EPA Safer Chemical Functional Use Classes -> Enzymes and Enzyme Stabilizers、Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern、EPA Safer Chemical Functional Use Classes -> Skin Conditioning Agents、Safer Chemical Classes -> Green half-circle - The chemical is expected to be of low concern、Cosmetics -> Hair conditioning、Antistatic、Skin conditioning、Industry Uses: Not Known or Reasonably Ascertainable、Household Products: Information on 5 consumer products that contain Methionine in the following categories is provided:、• Personal Care、Methods of Manufacturing: The production method of choice for L-methionine is still the enzymatic resolution of racemic N-acetyl-methionine using acylase from Aspergillus oryzae. The production is carried out in a continuously operated fixed-bed or enzyme membrane reactor. Alternatively、L-methionine may be produced by microbial conversion of the corresponding 5-substituted hydantoin. With growing cells of Pseudomonas sp. strain NS671、D、L-5-(2-methylthioethyl)hydantoin was converted to L-methionine、a final concentration of 34 g、L and a molar yield of 93% have been obtained.、The most economic way for production of D、L-methionine is the chemical process based on acrolein、methyl mercaptan、hydrogen cyanide、and ammonium carbonate. beta-Methylthiopropionaldehyde、formed by addition of methyl mercaptan to acrolein、is the intermediate that reacts with hydrogen cyanide to give alpha-hydroxy-gamma-methylthiobutyronitrile. Treatment with ammonium carbonate leads to 5-(beta-methylthioethyl)hydantoin that is saponified by potassium carbonate giving D、L-methionine in up to 95% yield、calculated on acrolein.、L-Methionine、Formulations、Preparations: NF、feed 98%、USP and FCC grades、99% feed grade、Racemate mixture of D- and L- methionine、Consumption Patterns: Used almost exclusively to improve the nutritive value of animal feeds、U.S. Production: 2021: 246、400 lb、(1992) No data、World market for L-methionine in 1982: 150 tons、World market for DL-methionine in 1982: 110、000 tons、Production volumes for non-confidential chemicals reported under the Inventory Update Rule. [Table#4914]、General Manufacturing Information: Not Known or Reasonably Ascertainable、Methionine: ACTIVE、L-Methionine: ACTIVE、... Available as d、l-methionine and as calcium salt of hydroxy analog of methionine. These products are used ... in animal feeds ... Relative biological value of these compared to l-methionine ... evidence suggests equivalency on mole basis both in rats and man.、The D-form of methionine is as equally nutritive as the L-form、so that DL-methionine which is inexpensively produced by the chemical synthesis is primarily used as a feed supplement、The amino acids that are incorporated into mammalian protein are alpha-amino acids、with the exception of proline、which is an alpha-imino acid. This means that they have a carboxyl group、an amino nitrogen group、and a side chain attached to a central alpha-carbon. Functional differences among the amino acids lie in the structure of their side chains. In addition to differences in size、these side groups carry different charges at physiological pH (e.g.、nonpolar、uncharged but polar、negatively charged、positively charged)、some groups are hydrophobic (e.g.、branched chain and aromatic amino acids) and some hydrophilic (most others). These side chains have an important bearing on the ways in which the higher orders of protein structure are stabilized and are intimate parts of many other aspects of protein function. |
登记用途：Uses: CIR ingredient: Methionine、An essential amino acid、Used therapeutically as an antidote for acetaminophen poisoning and a urinary acidifier、[Merck Index] Chelating agent for heavy metals、[ChemIDplus] Used as a flavoring agent and nutritional supplement for foods、[FDA] Used in pharmaceuticals、as a feed additive、for vegetable oil enrichment、and as single cell protein、[NTP] Permitted for use as an inert ingredient in non-food pesticide products、[EPA]、Farming (Feed Additives) [Category: Industry]、Feed additive、vegetable oil enrichment、single-cell protein、DL-Methionine、Nutrient、BIOLOGICAL ACTIVITIES: Anticataract、antidote (acteaminophen、paracetamol)、antieczemic、antihepatotic、antioxidant、antiparkinsonian、cancer-preventive、emetic、essential、glutathionigenic、heptoprotective、lioptropic、urine-acidifier、urine-deodorant、THERAPEUTIC CATEGORY: Hepatoprotectant、antidote (acetaminophen poisoning)、urinary acidifier、For more Uses (Complete) data for (L)-Methionine (6 total)、please visit the HSDB record page.、Use (kg、approx.) in Germany (2009): >25000、Consumption (g per capita、approx.) in Germany (2009): 0.305、Calculated removal (%): 92.1、Used for protein synthesis including the formation of SAMe、L-homocysteine、L-cysteine、taurine、and sulfate.、Use Classification: EPA Safer Chemical Functional Use Classes -> Enzymes and Enzyme Stabilizers、Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern、EPA Safer Chemical Functional Use Classes -> Skin Conditioning Agents、Safer Chemical Classes -> Green half-circle - The chemical is expected to be of low concern、Cosmetics -> Hair conditioning、Antistatic、Skin conditioning、Industry Uses: Not Known or Reasonably Ascertainable、Household Products: Information on 5 consumer products that contain Methionine in the following categories is provided:、• Personal Care、Methods of Manufacturing: The production method of choice for L-methionine is still the enzymatic resolution of racemic N-acetyl-methionine using acylase from Aspergillus oryzae. The production is carried out in a continuously operated fixed-bed or enzyme membrane reactor. Alternatively、L-methionine may be produced by microbial conversion of the corresponding 5-substituted hydantoin. With growing cells of Pseudomonas sp. strain NS671、D、L-5-(2-methylthioethyl)hydantoin was converted to L-methionine、a final concentration of 34 g、L and a molar yield of 93% have been obtained.、The most economic way for production of D、L-methionine is the chemical process based on acrolein、methyl mercaptan、hydrogen cyanide、and ammonium carbonate. beta-Methylthiopropionaldehyde、formed by addition of methyl mercaptan to acrolein、is the intermediate that reacts with hydrogen cyanide to give alpha-hydroxy-gamma-methylthiobutyronitrile. Treatment with ammonium carbonate leads to 5-(beta-methylthioethyl)hydantoin that is saponified by potassium carbonate giving D、L-methionine in up to 95% yield、calculated on acrolein.、L-Methionine、Formulations、Preparations: NF、feed 98%、USP and FCC grades、99% feed grade、Racemate mixture of D- and L- methionine、Consumption Patterns: Used almost exclusively to improve the nutritive value of animal feeds、U.S. Production: 2021: 246、400 lb、(1992) No data、World market for L-methionine in 1982: 150 tons、World market for DL-methionine in 1982: 110、000 tons、Production volumes for non-confidential chemicals reported under the Inventory Update Rule. [Table#4914]、General Manufacturing Information: Not Known or Reasonably Ascertainable、Methionine: ACTIVE、L-Methionine: ACTIVE、... Available as d、l-methionine and as calcium salt of hydroxy analog of methionine. These products are used ... in animal feeds ... Relative biological value of these compared to l-methionine ... evidence suggests equivalency on mole basis both in rats and man.、The D-form of methionine is as equally nutritive as the L-form、so that DL-methionine which is inexpensively produced by the chemical synthesis is primarily used as a feed supplement、The amino acids that are incorporated into mammalian protein are alpha-amino acids、with the exception of proline、which is an alpha-imino acid. This means that they have a carboxyl group、an amino nitrogen group、and a side chain attached to a central alpha-carbon. Functional differences among the amino acids lie in the structure of their side chains. In addition to differences in size、these side groups carry different charges at physiological pH (e.g.、nonpolar、uncharged but polar、negatively charged、positively charged)、some groups are hydrophobic (e.g.、branched chain and aromatic amino acids) and some hydrophilic (most others). These side chains have an important bearing on the ways in which the higher orders of protein structure are stabilized and are intimate parts of many other aspects of protein function.。
L-[35S]蛋氨酸 是一种化工化合物，登记 CAS 号为 3654-96-4，分子式 C5H11NO2S（分子量 149.21）。
登记 CAS 号：3654-96-4
其分子式 C5H11NO2S 由 5 个碳、11 个氢、1 个氮、2 个氧、1 个硫 组成。
别名/同义词：L-[35S]蛋氨酸 · L-[35S]METHIONINE
L-[35S]蛋氨酸 的 CAS 登记号为 3654-96-4。
分子式 C5H11NO2S，分子量 149.21。
别名/同义词：L-[35S]蛋氨酸、L-[35S]METHIONINE。
登记用途：Uses: CIR ingredient: Methionine、An essential amino acid、Used therapeutically as an antidote for acetaminophen poisoning and a urinary acidifier、[Merck Index] Chelating agent for heavy metals、[ChemIDplus] Used as a flavoring agent and nutritional supplement for foods、[FDA] Used in pharmaceuticals、as a feed additive、for vegetable oil enrichment、and as single cell protein、[NTP] Permitted for use as an inert ingredient in non-food pesticide products、[EPA]、Farming (Feed Additives) [Category: Industry]、Feed additive、vegetable oil enrichment、single-cell protein、DL-Methionine、Nutrient、BIOLOGICAL ACTIVITIES: Anticataract、antidote (acteaminophen、paracetamol)、antieczemic、antihepatotic、antioxidant、antiparkinsonian、cancer-preventive、emetic、essential、glutathionigenic、heptoprotective、lioptropic、urine-acidifier、urine-deodorant、THERAPEUTIC CATEGORY: Hepatoprotectant、antidote (acetaminophen poisoning)、urinary acidifier、For more Uses (Complete) data for (L)-Methionine (6 total)、please visit the HSDB record page.、Use (kg、approx.) in Germany (2009): >25000、Consumption (g per capita、approx.) in Germany (2009): 0.305、Calculated removal (%): 92.1、Used for protein synthesis including the formation of SAMe、L-homocysteine、L-cysteine、taurine、and sulfate.、Use Classification: EPA Safer Chemical Functional Use Classes -> Enzymes and Enzyme Stabilizers、Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern、EPA Safer Chemical Functional Use Classes -> Skin Conditioning Agents、Safer Chemical Classes -> Green half-circle - The chemical is expected to be of low concern、Cosmetics -> Hair conditioning、Antistatic、Skin conditioning、Industry Uses: Not Known or Reasonably Ascertainable、Household Products: Information on 5 consumer products that contain Methionine in the following categories is provided:、• Personal Care、Methods of Manufacturing: The production method of choice for L-methionine is still the enzymatic resolution of racemic N-acetyl-methionine using acylase from Aspergillus oryzae. The production is carried out in a continuously operated fixed-bed or enzyme membrane reactor. Alternatively、L-methionine may be produced by microbial conversion of the corresponding 5-substituted hydantoin. With growing cells of Pseudomonas sp. strain NS671、D、L-5-(2-methylthioethyl)hydantoin was converted to L-methionine、a final concentration of 34 g、L and a molar yield of 93% have been obtained.、The most economic way for production of D、L-methionine is the chemical process based on acrolein、methyl mercaptan、hydrogen cyanide、and ammonium carbonate. beta-Methylthiopropionaldehyde、formed by addition of methyl mercaptan to acrolein、is the intermediate that reacts with hydrogen cyanide to give alpha-hydroxy-gamma-methylthiobutyronitrile. Treatment with ammonium carbonate leads to 5-(beta-methylthioethyl)hydantoin that is saponified by potassium carbonate giving D、L-methionine in up to 95% yield、calculated on acrolein.、L-Methionine、Formulations、Preparations: NF、feed 98%、USP and FCC grades、99% feed grade、Racemate mixture of D- and L- methionine、Consumption Patterns: Used almost exclusively to improve the nutritive value of animal feeds、U.S. Production: 2021: 246、400 lb、(1992) No data、World market for L-methionine in 1982: 150 tons、World market for DL-methionine in 1982: 110、000 tons、Production volumes for non-confidential chemicals reported under the Inventory Update Rule. [Table#4914]、General Manufacturing Information: Not Known or Reasonably Ascertainable、Methionine: ACTIVE、L-Methionine: ACTIVE、... Available as d、l-methionine and as calcium salt of hydroxy analog of methionine. These products are used ... in animal feeds ... Relative biological value of these compared to l-methionine ... evidence suggests equivalency on mole basis both in rats and man.、The D-form of methionine is as equally nutritive as the L-form、so that DL-methionine which is inexpensively produced by the chemical synthesis is primarily used as a feed supplement、The amino acids that are incorporated into mammalian protein are alpha-amino acids、with the exception of proline、which is an alpha-imino acid. This means that they have a carboxyl group、an amino nitrogen group、and a side chain attached to a central alpha-carbon. Functional differences among the amino acids lie in the structure of their side chains. In addition to differences in size、these side groups carry different charges at physiological pH (e.g.、nonpolar、uncharged but polar、negatively charged、positively charged)、some groups are hydrophobic (e.g.、branched chain and aromatic amino acids) and some hydrophilic (most others). These side chains have an important bearing on the ways in which the higher orders of protein structure are stabilized and are intimate parts of many other aspects of protein function.。
L-[35S]蛋氨酸（CAS 3654-96-4）的独立参考数据，整理自公开化学数据库。
| CAS 号 | 3654-96-4 |
|---|---|
| PubChem CID | 6137 |
| 分子式 | C5H11NO2S |
| IUPAC 名称 | (2S)-2-amino-4-methylsulfanylbutanoic acid |
| UNII（FDA） | AE28F7PNPL |
| Molecular Weight | 149.21 |
|---|---|
| XLogP3 | -1.9 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 4 |
| Exact Mass | 149.05104977 |
| Monoisotopic Mass | 149.05104977 |
| Topological Polar Surface Area | 88.6 |
| Heavy Atom Count | 9 |
| Boiling Point | 181 °C (decomposes) |
|---|---|
| Melting Point | 283 |
| Melting Point | 284 °C |
| Solubility | 56600 |
| Solubility | In water, 56.6 g/L at 25 °C |
| Solubility | 56.6 mg/mL |
| Vapor Pressure | 0.00000052 [mmHg] |
| LogP | -1.87 |
| LogP | log Kow = -1.87 |
| Ionization Efficiency | 2.7 |
L-methionine; 63-68-3; methionine; h-Met-oh; (S)-2-Amino-4-(methylthio)butanoic acid; Cymethion; L-(-)-Methionine; S-Methionine; L-Methioninum; Neo-methidin; Methilanin; (S)-methionine; (L)-Methionine; metionina; Acimethin; L-Methionin
| 法规与食品接触 | EU Flavoring substances FDA Substance added to food: FLAVOR ENHANCER, FLAVORING AGENT OR ADJUVANT, NUTRIENT SUPPLEMENT Flavoring Agents CIR / INCI: Cosmetic ingredients (Methionine) -> CIR (Cosmetic Ingredient Review) CIR / INCI: Skin conditioning; Antistatic; Hair conditioning |
|---|---|
| GHS 通报统计 | 97.6% (206 / 211) |
| GHS 通报统计 | 97.6% (206 / 211) |
|---|
L-[35S]蛋氨酸 · CAS 3654-96-4 · C5H11NO2S. UNII AE28F7PNPL. Boiling Point: 181 °C (decomposes); Melting Point: 283; Melting Point: 284 °C.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: L-[35S]METHIONINE