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L-[35S]METHIONINE

CAS 3654-96-4C5H11NO2SMW 149.21

L-[35S]METHIONINE (CAS 3654-96-4) — formula C5H11NO2S, molecular weight 149.21.

Product Description

L-[35S]METHIONINE (CAS 3654-96-4) is classified under Food Additives, with molecular formula C5H11NO2S and molecular weight 149.21, and serves as a key raw material in the food and beverage industry — commonly applied as a food additive, nutritional supplement, or processing aid where regulatory-grade purity is required. Jinan Shenghe Chemical Co., Ltd. supplies L-[35S]METHIONINE at commercial scale with stable lot-to-lot quality, accompanied by COA and full specification documentation. Typical categorization: Food Additives.

Product Overview

CAS Number3654-96-4
Molecular FormulaC5H11NO2S
Molecular Weight149.21
Melting Point283
Boiling Point181 °C (decomposes)
LogP-1.87
ApplicationsUses: CIR ingredient: Methionine, An essential amino acid, Used therapeutically as an antidote for acetaminophen poisoning and a urinary acidifier, [Merck Index] Chelating agent for heavy metals, [ChemIDplus] Used as a flavoring agent and nutritional supplement for foods, [FDA] Used in pharmaceuticals, as a feed additive, for vegetable oil enrichment, and as single cell protein, [NTP] Permitted for use as an inert ingredient in non-food pesticide products, [EPA], Farming (Feed Additives) [Category: Industry], Feed additive, vegetable oil enrichment, single-cell protein, DL-Methionine, Nutrient, BIOLOGICAL ACTIVITIES: Anticataract, antidote (acteaminophen, paracetamol), antieczemic, antihepatotic, antioxidant, antiparkinsonian, cancer-preventive, emetic, essential, glutathionigenic, heptoprotective, lioptropic, urine-acidifier, urine-deodorant, THERAPEUTIC CATEGORY: Hepatoprotectant, antidote (acetaminophen poisoning), urinary acidifier, For more Uses (Complete) data for (L)-Methionine (6 total), please visit the HSDB record page., Use (kg, approx.) in Germany (2009): >25000, Consumption (g per capita, approx.) in Germany (2009): 0.305, Calculated removal (%): 92.1, Used for protein synthesis including the formation of SAMe, L-homocysteine, L-cysteine, taurine, and sulfate., Use Classification: EPA Safer Chemical Functional Use Classes -> Enzymes and Enzyme Stabilizers, Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern, EPA Safer Chemical Functional Use Classes -> Skin Conditioning Agents, Safer Chemical Classes -> Green half-circle - The chemical is expected to be of low concern, Cosmetics -> Hair conditioning, Antistatic, Skin conditioning, Industry Uses: Not Known or Reasonably Ascertainable, Household Products: Information on 5 consumer products that contain Methionine in the following categories is provided:, • Personal Care, Methods of Manufacturing: The production method of choice for L-methionine is still the enzymatic resolution of racemic N-acetyl-methionine using acylase from Aspergillus oryzae. The production is carried out in a continuously operated fixed-bed or enzyme membrane reactor. Alternatively, L-methionine may be produced by microbial conversion of the corresponding 5-substituted hydantoin. With growing cells of Pseudomonas sp. strain NS671, D, L-5-(2-methylthioethyl)hydantoin was converted to L-methionine, a final concentration of 34 g, L and a molar yield of 93% have been obtained., The most economic way for production of D, L-methionine is the chemical process based on acrolein, methyl mercaptan, hydrogen cyanide, and ammonium carbonate. beta-Methylthiopropionaldehyde, formed by addition of methyl mercaptan to acrolein, is the intermediate that reacts with hydrogen cyanide to give alpha-hydroxy-gamma-methylthiobutyronitrile. Treatment with ammonium carbonate leads to 5-(beta-methylthioethyl)hydantoin that is saponified by potassium carbonate giving D, L-methionine in up to 95% yield, calculated on acrolein., L-Methionine, Formulations, Preparations: NF, feed 98%, USP and FCC grades, 99% feed grade, Racemate mixture of D- and L- methionine, Consumption Patterns: Used almost exclusively to improve the nutritive value of animal feeds, U.S. Production: 2021: 246, 400 lb, (1992) No data, World market for L-methionine in 1982: 150 tons, World market for DL-methionine in 1982: 110, 000 tons, Production volumes for non-confidential chemicals reported under the Inventory Update Rule. [Table#4914], General Manufacturing Information: Not Known or Reasonably Ascertainable, Methionine: ACTIVE, L-Methionine: ACTIVE, ... Available as d, l-methionine and as calcium salt of hydroxy analog of methionine. These products are used ... in animal feeds ... Relative biological value of these compared to l-methionine ... evidence suggests equivalency on mole basis both in rats and man., The D-form of methionine is as equally nutritive as the L-form, so that DL-methionine which is inexpensively produced by the chemical synthesis is primarily used as a feed supplement, The amino acids that are incorporated into mammalian protein are alpha-amino acids, with the exception of proline, which is an alpha-imino acid. This means that they have a carboxyl group, an amino nitrogen group, and a side chain attached to a central alpha-carbon. Functional differences among the amino acids lie in the structure of their side chains. In addition to differences in size, these side groups carry different charges at physiological pH (e.g., nonpolar, uncharged but polar, negatively charged, positively charged), some groups are hydrophobic (e.g., branched chain and aromatic amino acids) and some hydrophilic (most others). These side chains have an important bearing on the ways in which the higher orders of protein structure are stabilized and are intimate parts of many other aspects of protein function.

Applications

Documented applications: Uses: CIR ingredient: Methionine, An essential amino acid, Used therapeutically as an antidote for acetaminophen poisoning and a urinary acidifier, [Merck Index] Chelating agent for heavy metals, [ChemIDplus] Used as a flavoring agent and nutritional supplement for foods, [FDA] Used in pharmaceuticals, as a feed additive, for vegetable oil enrichment, and as single cell protein, [NTP] Permitted for use as an inert ingredient in non-food pesticide products, [EPA], Farming (Feed Additives) [Category: Industry], Feed additive, vegetable oil enrichment, single-cell protein, DL-Methionine, Nutrient, BIOLOGICAL ACTIVITIES: Anticataract, antidote (acteaminophen, paracetamol), antieczemic, antihepatotic, antioxidant, antiparkinsonian, cancer-preventive, emetic, essential, glutathionigenic, heptoprotective, lioptropic, urine-acidifier, urine-deodorant, THERAPEUTIC CATEGORY: Hepatoprotectant, antidote (acetaminophen poisoning), urinary acidifier, For more Uses (Complete) data for (L)-Methionine (6 total), please visit the HSDB record page., Use (kg, approx.) in Germany (2009): >25000, Consumption (g per capita, approx.) in Germany (2009): 0.305, Calculated removal (%): 92.1, Used for protein synthesis including the formation of SAMe, L-homocysteine, L-cysteine, taurine, and sulfate., Use Classification: EPA Safer Chemical Functional Use Classes -> Enzymes and Enzyme Stabilizers, Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern, EPA Safer Chemical Functional Use Classes -> Skin Conditioning Agents, Safer Chemical Classes -> Green half-circle - The chemical is expected to be of low concern, Cosmetics -> Hair conditioning, Antistatic, Skin conditioning, Industry Uses: Not Known or Reasonably Ascertainable, Household Products: Information on 5 consumer products that contain Methionine in the following categories is provided:, • Personal Care, Methods of Manufacturing: The production method of choice for L-methionine is still the enzymatic resolution of racemic N-acetyl-methionine using acylase from Aspergillus oryzae. The production is carried out in a continuously operated fixed-bed or enzyme membrane reactor. Alternatively, L-methionine may be produced by microbial conversion of the corresponding 5-substituted hydantoin. With growing cells of Pseudomonas sp. strain NS671, D, L-5-(2-methylthioethyl)hydantoin was converted to L-methionine, a final concentration of 34 g, L and a molar yield of 93% have been obtained., The most economic way for production of D, L-methionine is the chemical process based on acrolein, methyl mercaptan, hydrogen cyanide, and ammonium carbonate. beta-Methylthiopropionaldehyde, formed by addition of methyl mercaptan to acrolein, is the intermediate that reacts with hydrogen cyanide to give alpha-hydroxy-gamma-methylthiobutyronitrile. Treatment with ammonium carbonate leads to 5-(beta-methylthioethyl)hydantoin that is saponified by potassium carbonate giving D, L-methionine in up to 95% yield, calculated on acrolein., L-Methionine, Formulations, Preparations: NF, feed 98%, USP and FCC grades, 99% feed grade, Racemate mixture of D- and L- methionine, Consumption Patterns: Used almost exclusively to improve the nutritive value of animal feeds, U.S. Production: 2021: 246, 400 lb, (1992) No data, World market for L-methionine in 1982: 150 tons, World market for DL-methionine in 1982: 110, 000 tons, Production volumes for non-confidential chemicals reported under the Inventory Update Rule. [Table#4914], General Manufacturing Information: Not Known or Reasonably Ascertainable, Methionine: ACTIVE, L-Methionine: ACTIVE, ... Available as d, l-methionine and as calcium salt of hydroxy analog of methionine. These products are used ... in animal feeds ... Relative biological value of these compared to l-methionine ... evidence suggests equivalency on mole basis both in rats and man., The D-form of methionine is as equally nutritive as the L-form, so that DL-methionine which is inexpensively produced by the chemical synthesis is primarily used as a feed supplement, The amino acids that are incorporated into mammalian protein are alpha-amino acids, with the exception of proline, which is an alpha-imino acid. This means that they have a carboxyl group, an amino nitrogen group, and a side chain attached to a central alpha-carbon. Functional differences among the amino acids lie in the structure of their side chains. In addition to differences in size, these side groups carry different charges at physiological pH (e.g., nonpolar, uncharged but polar, negatively charged, positively charged), some groups are hydrophobic (e.g., branched chain and aromatic amino acids) and some hydrophilic (most others). These side chains have an important bearing on the ways in which the higher orders of protein structure are stabilized and are intimate parts of many other aspects of protein function..

Technical Profile

What this product is

L-[35S]METHIONINE is a chemical compound with CAS registry number 3654-96-4 and molecular formula C5H11NO2S (molecular weight 149.21).

Identification

CAS number: 3654-96-4

Its molecular formula C5H11NO2S comprises 5 C, 11 H, 1 N, 2 O, 1 S atoms.

Also known as: L-[35S]METHIONINE · L-[35S]蛋氨酸

Frequently Asked Questions

What is the CAS number of L-[35S]METHIONINE?

The CAS registry number of L-[35S]METHIONINE is 3654-96-4.

What is the molecular formula and molecular weight of L-[35S]METHIONINE?

Molecular formula C5H11NO2S, molecular weight 149.21.

What other names is L-[35S]METHIONINE known by?

It is also registered under: L-[35S]METHIONINE, L-[35S]蛋氨酸.

What are the documented applications of L-[35S]METHIONINE?

Recorded applications: Uses: CIR ingredient: Methionine, An essential amino acid, Used therapeutically as an antidote for acetaminophen poisoning and a urinary acidifier, [Merck Index] Chelating agent for heavy metals, [ChemIDplus] Used as a flavoring agent and nutritional supplement for foods, [FDA] Used in pharmaceuticals, as a feed additive, for vegetable oil enrichment, and as single cell protein, [NTP] Permitted for use as an inert ingredient in non-food pesticide products, [EPA], Farming (Feed Additives) [Category: Industry], Feed additive, vegetable oil enrichment, single-cell protein, DL-Methionine, Nutrient, BIOLOGICAL ACTIVITIES: Anticataract, antidote (acteaminophen, paracetamol), antieczemic, antihepatotic, antioxidant, antiparkinsonian, cancer-preventive, emetic, essential, glutathionigenic, heptoprotective, lioptropic, urine-acidifier, urine-deodorant, THERAPEUTIC CATEGORY: Hepatoprotectant, antidote (acetaminophen poisoning), urinary acidifier, For more Uses (Complete) data for (L)-Methionine (6 total), please visit the HSDB record page., Use (kg, approx.) in Germany (2009): >25000, Consumption (g per capita, approx.) in Germany (2009): 0.305, Calculated removal (%): 92.1, Used for protein synthesis including the formation of SAMe, L-homocysteine, L-cysteine, taurine, and sulfate., Use Classification: EPA Safer Chemical Functional Use Classes -> Enzymes and Enzyme Stabilizers, Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern, EPA Safer Chemical Functional Use Classes -> Skin Conditioning Agents, Safer Chemical Classes -> Green half-circle - The chemical is expected to be of low concern, Cosmetics -> Hair conditioning, Antistatic, Skin conditioning, Industry Uses: Not Known or Reasonably Ascertainable, Household Products: Information on 5 consumer products that contain Methionine in the following categories is provided:, • Personal Care, Methods of Manufacturing: The production method of choice for L-methionine is still the enzymatic resolution of racemic N-acetyl-methionine using acylase from Aspergillus oryzae. The production is carried out in a continuously operated fixed-bed or enzyme membrane reactor. Alternatively, L-methionine may be produced by microbial conversion of the corresponding 5-substituted hydantoin. With growing cells of Pseudomonas sp. strain NS671, D, L-5-(2-methylthioethyl)hydantoin was converted to L-methionine, a final concentration of 34 g, L and a molar yield of 93% have been obtained., The most economic way for production of D, L-methionine is the chemical process based on acrolein, methyl mercaptan, hydrogen cyanide, and ammonium carbonate. beta-Methylthiopropionaldehyde, formed by addition of methyl mercaptan to acrolein, is the intermediate that reacts with hydrogen cyanide to give alpha-hydroxy-gamma-methylthiobutyronitrile. Treatment with ammonium carbonate leads to 5-(beta-methylthioethyl)hydantoin that is saponified by potassium carbonate giving D, L-methionine in up to 95% yield, calculated on acrolein., L-Methionine, Formulations, Preparations: NF, feed 98%, USP and FCC grades, 99% feed grade, Racemate mixture of D- and L- methionine, Consumption Patterns: Used almost exclusively to improve the nutritive value of animal feeds, U.S. Production: 2021: 246, 400 lb, (1992) No data, World market for L-methionine in 1982: 150 tons, World market for DL-methionine in 1982: 110, 000 tons, Production volumes for non-confidential chemicals reported under the Inventory Update Rule. [Table#4914], General Manufacturing Information: Not Known or Reasonably Ascertainable, Methionine: ACTIVE, L-Methionine: ACTIVE, ... Available as d, l-methionine and as calcium salt of hydroxy analog of methionine. These products are used ... in animal feeds ... Relative biological value of these compared to l-methionine ... evidence suggests equivalency on mole basis both in rats and man., The D-form of methionine is as equally nutritive as the L-form, so that DL-methionine which is inexpensively produced by the chemical synthesis is primarily used as a feed supplement, The amino acids that are incorporated into mammalian protein are alpha-amino acids, with the exception of proline, which is an alpha-imino acid. This means that they have a carboxyl group, an amino nitrogen group, and a side chain attached to a central alpha-carbon. Functional differences among the amino acids lie in the structure of their side chains. In addition to differences in size, these side groups carry different charges at physiological pH (e.g., nonpolar, uncharged but polar, negatively charged, positively charged), some groups are hydrophobic (e.g., branched chain and aromatic amino acids) and some hydrophilic (most others). These side chains have an important bearing on the ways in which the higher orders of protein structure are stabilized and are intimate parts of many other aspects of protein function..

PubChem Public Data

Independent reference data for L-[35S]METHIONINE (CAS 3654-96-4), compiled from public chemistry databases.

Registry identifiers across databases

CAS 号3654-96-4
PubChem CID6137
分子式C5H11NO2S
IUPAC 名称(2S)-2-amino-4-methylsulfanylbutanoic acid
UNII(FDA)AE28F7PNPL

Computed descriptors

Molecular Weight149.21
XLogP3-1.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Exact Mass149.05104977
Monoisotopic Mass149.05104977
Topological Polar Surface Area88.6
Heavy Atom Count9

Physicochemical values on record

Boiling Point181 °C (decomposes)
Melting Point283
Melting Point284 °C
Solubility56600
SolubilityIn water, 56.6 g/L at 25 °C
Solubility56.6 mg/mL
Vapor Pressure0.00000052 [mmHg]
LogP-1.87
LogPlog Kow = -1.87
Ionization Efficiency2.7

Synonyms and trade names

L-methionine; 63-68-3; methionine; h-Met-oh; (S)-2-Amino-4-(methylthio)butanoic acid; Cymethion; L-(-)-Methionine; S-Methionine; L-Methioninum; Neo-methidin; Methilanin; (S)-methionine; (L)-Methionine; metionina; Acimethin; L-Methionin

Regulatory listings held on file

法规与食品接触EU Flavoring substances
FDA Substance added to food: FLAVOR ENHANCER, FLAVORING AGENT OR ADJUVANT, NUTRIENT SUPPLEMENT
Flavoring Agents
CIR / INCI: Cosmetic ingredients (Methionine) -> CIR (Cosmetic Ingredient Review)
CIR / INCI: Skin conditioning; Antistatic; Hair conditioning
GHS 通报统计97.6% (206 / 211)

GHS hazard classification

GHS 通报统计97.6% (206 / 211)

What the public record says

L-[35S]蛋氨酸 · CAS 3654-96-4 · C5H11NO2S. UNII AE28F7PNPL. Boiling Point: 181 °C (decomposes); Melting Point: 283; Melting Point: 284 °C.

Source: PubChem / Wikidata; the batch COA governs where values differ.

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