Amifostine (CAS 20537-88-6) — formula C5H15N2O3PS, molecular weight 214.23; category organic chemicals.
Amifostine (CAS 20537-88-6) is a chemical raw material in the organic chemicals category. Its molecular formula C5H15N2O3PS comprises 5 C, 15 H, 2 N, 3 O, 1 P, 1 S atoms. Its molecular weight is about 214.23. Reported physicochemical data: LogP about -1.9. As a sourcing and distribution partner we help locate and compare this item across domestic and cross-border channels, arranging samples and batch orders with full COA and compliance files.
| CAS Number | 20537-88-6 |
|---|---|
| Molecular Formula | C5H15N2O3PS |
| Molecular Weight | 214.23 |
| LogP | -1.9 |
| Applications | To reduce the cumulative renal toxicity associated with repeated administration of cisplatin in patients with advanced ovarian cancer ... reduce the incidence of moderate to severe xerostomia in patients undergoing post-operative radiation treatment for head and neck cancer, THERAP CAT: Radioprotective agent, Methods of Manufacturing: Preparation: J.R. Piper, T.P. Johnston, US 3892824 (1975 to Southern Research Institute), 3-Propanediamine is monoalkylated with 2-chloroethanol to form 2-ethanol and the free OH converted to Br by use of HBr. Treating the resulting alkyl bromide with sodium thiophosphate |
| Category | Organic Chemicals |
Documented applications: To reduce the cumulative renal toxicity associated with repeated administration of cisplatin in patients with advanced ovarian cancer ... reduce the incidence of moderate to severe xerostomia in patients undergoing post-operative radiation treatment for head and neck cancer, THERAP CAT: Radioprotective agent, Methods of Manufacturing: Preparation: J.R. Piper, T.P. Johnston, US 3892824 (1975 to Southern Research Institute), 3-Propanediamine is monoalkylated with 2-chloroethanol to form 2-ethanol and the free OH converted to Br by use of HBr. Treating the resulting alkyl bromide with sodium thiophosphate.
Amifostine is a carbon-based organic compound with CAS registry number 20537-88-6 and molecular formula C5H15N2O3PS (molecular weight 214.23), belonging to the organic chemicals segment of chemical raw materials.
CAS number: 20537-88-6
Its molecular formula C5H15N2O3PS comprises 5 C, 15 H, 2 N, 3 O, 1 P, 1 S atoms.
Also known as: Amifostine · 氨磷汀
Category: organic chemicals
The CAS registry number of Amifostine is 20537-88-6.
Molecular formula C5H15N2O3PS, molecular weight 214.23.
It is also registered under: Amifostine, 氨磷汀.
Recorded applications: To reduce the cumulative renal toxicity associated with repeated administration of cisplatin in patients with advanced ovarian cancer ... reduce the incidence of moderate to severe xerostomia in patients undergoing post-operative radiation treatment for head and neck cancer, THERAP CAT: Radioprotective agent, Methods of Manufacturing: Preparation: J.R. Piper, T.P. Johnston, US 3892824 (1975 to Southern Research Institute), 3-Propanediamine is monoalkylated with 2-chloroethanol to form 2-ethanol and the free OH converted to Br by use of HBr. Treating the resulting alkyl bromide with sodium thiophosphate.
Category: Organic Chemicals.
Packaging is agreed per order, from lab-scale packs to bulk, and confirmed with each order rather than fixed on the page. A Certificate of Analysis (COA) ships with every batch and MSDS is available; where the end use carries a regulatory limit (food contact, pharmaceutical or cosmetic), state the standard at enquiry and the grade is set against it.
Independent reference data for Amifostine (CAS 20537-88-6), compiled from public chemistry databases.
| CAS Number | 20537-88-6 |
|---|---|
| PubChem CID | 2141 |
| Molecular Formula | C5H15N2O3PS |
| IUPAC Name | 2-(3-aminopropylamino)ethylsulfanylphosphonic acid |
| UNII (FDA) | ILA426L95O |
| Molecular Weight | 214.23 |
|---|---|
| XLogP3 | -4.5 |
| Hydrogen Bond Donor Count | 4 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 7 |
| Exact Mass | 214.05410052 |
| Monoisotopic Mass | 214.05410052 |
| Topological Polar Surface Area | 121 |
| Heavy Atom Count | 12 |
| Solubility | 1000 |
|---|---|
| Solubility | 1.87e+01 g/L |
| Solubility | 95% Ethanol < 0.01 (mg/mL) |
| Solubility | Chloroform < 0.01 (mg/mL) |
| Solubility | Toluene < 0.01 (mg/mL) |
| LogP | -1.9 |
amifostine; 20537-88-6; Ethiofos; Gammaphos; Ethyol; Apaetp; Aminopropylaminoethyl thiophosphate; Ethiofos Anhydrous; Amifostine Anhydrous; YM-08310; Amifostina; NSC-296961; WR 2721; WR-2721; DTXSID8022585; NSC296961
| Notified hazard statements | H302 (100%) |
|---|
Source: PubChem / Wikidata; the batch COA governs where values differ.
Supplier: Jinan Shenghe Chemical Co., Ltd.
中文页面: 氨磷汀