vinblastine (CAS 865-21-4) — formula C46H58N4O9, molecular weight 811.0; category organic chemicals.
| CAS Number | 865-21-4 |
|---|---|
| Molecular Formula | C46H58N4O9 |
| Molecular Weight | 811.0 |
| Melting Point | 267 |
| LogP | 3.7 |
| Applications | Uses: For treatment of breast cancer, testicular cancer, lymphomas, neuroblastoma, Hodgkin's and non-Hodgkin's lymphomas, mycosis fungoides, histiocytosis, and Kaposi's sarcoma., ... in the treatment of Hodgkins disease, Vinblastine sulfate USP, THERAP CAT: Antineoplastic, MEDICATION (VET), MEDICATION, For treatment of breast cancer, Methods of Manufacturing: ... Isolated from periwinkle, Vinca rosea Linn, Apocynaceae., BY EXTRACTING LEAVES, BARK, OR STEMS OF VINCA ROSEA ... ISOLATING ALKALOID ... BY PRECIPITATION & SOLVENT TECHNIQUES, & PURIFYING BY CHROMATOGRAPHY ... CONVERSION TO (1:1) SULFATE ... BY DISSOLVING ALKALOID IN EQUIMOLAR QUANTITY OF DILUTE SULFURIC ACID & ... EVAPORATING TO DRYNESS OR PRECIPITATING WITH SUITABLE ORG SOLVENT., VINBLASTINE SULFATE, Vinblastine and vincristine occur in Catharanthus roseus (L). The plant contains only very small amounts of vinblastine and vincristine, and their isolation is correspondingly difficult. First the alkaloids present are separated by extraction into alkaloid tartrate soluble in benzene and alkaloid tartrates insoluble in benzene. Vinblastine and vincristine belong to the first group. They then are separated by chromatography on aluminum oxide deactivated with acetic acid., Formulations, Preparations: Parenteral Injection, for IV use only 1 mg, mL, Vinblastine Sulfate Injection (with benzyl alcohol 0.9%), Abraxis, Sterile, for IV use only 10 mg, Bedford, Vials, 10 mg, Vinblastine sulfate, General Manufacturing Information: VINBLASTINE IS CLASS II IMMUNOSUPPRESSIVE DRUG, BUT IT HAS NOT BEEN EXPLOITED FOR THIS PURPOSE., Antitumor alkaloid |
| Category | Organic Chemicals |
Documented applications: Uses: For treatment of breast cancer, testicular cancer, lymphomas, neuroblastoma, Hodgkin's and non-Hodgkin's lymphomas, mycosis fungoides, histiocytosis, and Kaposi's sarcoma., ... in the treatment of Hodgkins disease, Vinblastine sulfate USP, THERAP CAT: Antineoplastic, MEDICATION (VET), MEDICATION, For treatment of breast cancer, Methods of Manufacturing: ... Isolated from periwinkle, Vinca rosea Linn, Apocynaceae., BY EXTRACTING LEAVES, BARK, OR STEMS OF VINCA ROSEA ... ISOLATING ALKALOID ... BY PRECIPITATION & SOLVENT TECHNIQUES, & PURIFYING BY CHROMATOGRAPHY ... CONVERSION TO (1:1) SULFATE ... BY DISSOLVING ALKALOID IN EQUIMOLAR QUANTITY OF DILUTE SULFURIC ACID & ... EVAPORATING TO DRYNESS OR PRECIPITATING WITH SUITABLE ORG SOLVENT., VINBLASTINE SULFATE, Vinblastine and vincristine occur in Catharanthus roseus (L). The plant contains only very small amounts of vinblastine and vincristine, and their isolation is correspondingly difficult. First the alkaloids present are separated by extraction into alkaloid tartrate soluble in benzene and alkaloid tartrates insoluble in benzene. Vinblastine and vincristine belong to the first group. They then are separated by chromatography on aluminum oxide deactivated with acetic acid., Formulations, Preparations: Parenteral Injection, for IV use only 1 mg, mL, Vinblastine Sulfate Injection (with benzyl alcohol 0.9%), Abraxis, Sterile, for IV use only 10 mg, Bedford, Vials, 10 mg, Vinblastine sulfate, General Manufacturing Information: VINBLASTINE IS CLASS II IMMUNOSUPPRESSIVE DRUG, BUT IT HAS NOT BEEN EXPLOITED FOR THIS PURPOSE., Antitumor alkaloid.
vinblastine is a carbon-based organic compound with CAS registry number 865-21-4 and molecular formula C46H58N4O9 (molecular weight 811.0), belonging to the organic chemicals segment of chemical raw materials.
CAS number: 865-21-4
Its molecular formula C46H58N4O9 comprises 46 C, 58 H, 4 N, 9 O atoms.
Also known as: vinblastine · 长春花碱
Category: organic chemicals
The CAS registry number of vinblastine is 865-21-4.
Molecular formula C46H58N4O9, molecular weight 811.0.
It is also registered under: vinblastine, 长春花碱.
Recorded applications: Uses: For treatment of breast cancer, testicular cancer, lymphomas, neuroblastoma, Hodgkin's and non-Hodgkin's lymphomas, mycosis fungoides, histiocytosis, and Kaposi's sarcoma., ... in the treatment of Hodgkins disease, Vinblastine sulfate USP, THERAP CAT: Antineoplastic, MEDICATION (VET), MEDICATION, For treatment of breast cancer, Methods of Manufacturing: ... Isolated from periwinkle, Vinca rosea Linn, Apocynaceae., BY EXTRACTING LEAVES, BARK, OR STEMS OF VINCA ROSEA ... ISOLATING ALKALOID ... BY PRECIPITATION & SOLVENT TECHNIQUES, & PURIFYING BY CHROMATOGRAPHY ... CONVERSION TO (1:1) SULFATE ... BY DISSOLVING ALKALOID IN EQUIMOLAR QUANTITY OF DILUTE SULFURIC ACID & ... EVAPORATING TO DRYNESS OR PRECIPITATING WITH SUITABLE ORG SOLVENT., VINBLASTINE SULFATE, Vinblastine and vincristine occur in Catharanthus roseus (L). The plant contains only very small amounts of vinblastine and vincristine, and their isolation is correspondingly difficult. First the alkaloids present are separated by extraction into alkaloid tartrate soluble in benzene and alkaloid tartrates insoluble in benzene. Vinblastine and vincristine belong to the first group. They then are separated by chromatography on aluminum oxide deactivated with acetic acid., Formulations, Preparations: Parenteral Injection, for IV use only 1 mg, mL, Vinblastine Sulfate Injection (with benzyl alcohol 0.9%), Abraxis, Sterile, for IV use only 10 mg, Bedford, Vials, 10 mg, Vinblastine sulfate, General Manufacturing Information: VINBLASTINE IS CLASS II IMMUNOSUPPRESSIVE DRUG, BUT IT HAS NOT BEEN EXPLOITED FOR THIS PURPOSE., Antitumor alkaloid.
Category: Organic Chemicals.
Independent reference data for vinblastine (CAS 865-21-4), compiled from public chemistry databases.
| CAS Registry Number | 865-21-4 |
|---|---|
| PubChem CID | 13342 |
| Molecular formula | C46H58N4O9 |
| UNII (FDA) | 5V9KLZ54CY |
| Molecular Weight | 811.0 |
|---|---|
| XLogP3 | 3.7 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 12 |
| Rotatable Bond Count | 10 |
| Exact Mass | 810.42037944 |
| Monoisotopic Mass | 810.42037944 |
| Topological Polar Surface Area | 154 |
| Heavy Atom Count | 59 |
| Melting Point | 267 |
|---|---|
| Melting Point | 211-216 °C |
| LogP | 3.7 |
| LogP | log Kow = 3.70 |
| LogP | 3.72 |
| Dissociation Constants | pKa1 = 5.4; pKa2 = 7.4 |
vinblastine; 865-21-4; Vinblastin; Vincaleucoblastin; Vinblastina; Vincoblastine; Vincaleukoblastine; Nincaluicolflastine; Vinblastinum; Vincaleucoblastine; NCI-C04842; 5V9KLZ54CY; NSC 47842; NDC 0002-1452-01; NSC-47842; (2ALPHA,2'BETA,3BETA,4ALPHA,5BETA)-VINCALEUKOBLASTINE
vinblastine · CAS 865-21-4 · C46H58N4O9. UNII 5V9KLZ54CY. Melting Point: 267; Melting Point: 211-216 °C; LogP: 3.7.
Source: PubChem / Wikidata; the batch COA governs where values differ.
Supplier: Jinan Shenghe Chemical Co., Ltd.
中文页面: 长春花碱