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Vandetanib

CAS 443913-73-3C22H24BrFN4O2MW 475.4

Vandetanib (CAS 443913-73-3) — formula C22H24BrFN4O2, molecular weight 475.4; category organic chemicals.

Product Description

Vandetanib (CAS 443913-73-3) is a chemical raw material in the organic chemicals category. Its molecular formula C22H24BrFN4O2 comprises 22 C, 24 H, 1 Br, 1 F, 4 N, 2 O atoms. Its molecular weight is about 475.4. Reported physicochemical data: LogP about log Kow = 5.0. As a sourcing and distribution partner we help locate and compare this item across domestic and cross-border channels, arranging samples and batch orders with full COA and compliance files.

Product Overview

CAS Number443913-73-3
Molecular FormulaC22H24BrFN4O2
Molecular Weight475.4
LogPlog Kow = 5.0
ApplicationsAntineoplastic, MEDICATION, Methods of Manufacturing: Preparation: L. F. A. Hennequin et al, World Intellectual Property Organization patent 01032651, eidem, United States of America patent 7173038 (2001
CategoryOrganic Chemicals

Applications

Documented applications: Antineoplastic, MEDICATION, Methods of Manufacturing: Preparation: L. F. A. Hennequin et al, World Intellectual Property Organization patent 01032651, eidem, United States of America patent 7173038 (2001.

Technical Profile

What this product is

Vandetanib is a carbon-based organic compound with CAS registry number 443913-73-3 and molecular formula C22H24BrFN4O2 (molecular weight 475.4), belonging to the organic chemicals segment of chemical raw materials.

Identification

CAS number: 443913-73-3

Its molecular formula C22H24BrFN4O2 comprises 22 C, 24 H, 1 Br, 1 F, 4 N, 2 O atoms.

Also known as: Vandetanib · 凡德他尼

Category: organic chemicals

Frequently Asked Questions

What is the CAS number of Vandetanib?

The CAS registry number of Vandetanib is 443913-73-3.

What is the molecular formula and molecular weight of Vandetanib?

Molecular formula C22H24BrFN4O2, molecular weight 475.4.

What other names is Vandetanib known by?

It is also registered under: Vandetanib, 凡德他尼.

What are the documented applications of Vandetanib?

Recorded applications: Antineoplastic, MEDICATION, Methods of Manufacturing: Preparation: L. F. A. Hennequin et al, World Intellectual Property Organization patent 01032651, eidem, United States of America patent 7173038 (2001.

Which category does Vandetanib belong to?

Category: Organic Chemicals.

Packaging & documentation

Packaging is agreed per order, from lab-scale packs to bulk, and confirmed with each order rather than fixed on the page. A Certificate of Analysis (COA) ships with every batch and MSDS is available; where the end use carries a regulatory limit (food contact, pharmaceutical or cosmetic), state the standard at enquiry and the grade is set against it.

PubChem Public Data

Independent reference data for Vandetanib (CAS 443913-73-3), compiled from public chemistry databases.

Registry identifiers across databases

CAS Registry Number443913-73-3
PubChem CID3081361
Molecular formulaC22H24BrFN4O2
IUPAC nameN-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine
UNII (FDA)YO460OQ37K

Computed descriptors

Molecular Weight475.4
XLogP34.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count6
Exact Mass474.10667
Monoisotopic Mass474.10667
Topological Polar Surface Area59.5
Heavy Atom Count30

Physicochemical values on record

Solubility0.008
LogPlog Kow = 5.0

Documented uses on record

    Preparation: L. F. A. Hennequin et al., World Intellectual Property Organization patent 01032651; eidem, United States of America patent 7173038 (2001, 2007 both to AstraZeneca).Vandetanib is currently approved as an alternative to local therapies for both unresectable and disseminated disease. Because Vandetanib can prolong the Q-T interval, it is contraindicated for use in patients with serious cardiac complications such as congenital long QT syndrome and uncompensated heart failure.

    Synonyms and trade names

    Vandetanib; 443913-73-3; Zactima; ZD6474; Caprelsa; N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine; N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine; ZD-6474; ZD 6474; GNF-PF-2188; ZD-64; NSC-744325; NSC-760766; DTXSID1046681; YO460OQ37K; N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-4-quinazolinamine

    GHS hazard classification

    Reported hazard statementsH302 (97.2%), H360 (11.1%), H373 (97.2%), H410 (97.2%)

    H302 (97.2%): Harmful if swallowed [Warning Acute toxicity, oral]

    H360 (11.1%): May damage fertility or the unborn child [Danger Reproductive toxicity]

    What the public record says

    Vandetanib · CAS 443913-73-3 · C22H24BrFN4O2. UNII YO460OQ37K. Solubility: 0.008; LogP: log Kow = 5.0.

    Source: PubChem / Wikidata; the batch COA governs where values differ.

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