Trimetrexate (CAS 52128-35-5) — formula C19H23N5O3, molecular weight 369.4; category organic chemicals.
Trimetrexate (CAS 52128-35-5) is a chemical raw material in the organic chemicals category. Its molecular formula C19H23N5O3 comprises 19 C, 23 H, 5 N, 3 O atoms. Its molecular weight is about 369.4. Reported physicochemical data: melting point around 215-217 °C, LogP about 2.5. As a sourcing and distribution partner we help locate and compare this item across domestic and cross-border channels, arranging samples and batch orders with full COA and compliance files.
| CAS Number | 52128-35-5 |
|---|---|
| Molecular Formula | C19H23N5O3 |
| Molecular Weight | 369.4 |
| Melting Point | 215-217 °C |
| LogP | 2.5 |
| Applications | MEDICATION, For use, with concurrent leucovorin administration (leucovorin protection), as an alternative therapy for the treatment of moderate-to-severe <i>Pneumocystis carinii</i> pneumonia (PCP) in immunocompromised patients, including patients with the acquired immunodeficiency syndrome (AIDS). Also used to treat several types of cancer including colon cancer, Lipophilic dihydrofolate reductase structurally related to methotrexate |
| Category | Organic Chemicals |
Documented applications: MEDICATION, For use, with concurrent leucovorin administration (leucovorin protection), as an alternative therapy for the treatment of moderate-to-severe <i>Pneumocystis carinii</i> pneumonia (PCP) in immunocompromised patients, including patients with the acquired immunodeficiency syndrome (AIDS). Also used to treat several types of cancer including colon cancer, Lipophilic dihydrofolate reductase structurally related to methotrexate.
Trimetrexate is a carbon-based organic compound with CAS registry number 52128-35-5 and molecular formula C19H23N5O3 (molecular weight 369.4), belonging to the organic chemicals segment of chemical raw materials.
CAS number: 52128-35-5
Its molecular formula C19H23N5O3 comprises 19 C, 23 H, 5 N, 3 O atoms.
Also known as: Trimetrexate · 5-甲基-6-(((3,4,5-三甲氧基苯基)氨基)甲基)喹唑啉-2,4-二胺
Category: organic chemicals
The CAS registry number of Trimetrexate is 52128-35-5.
Molecular formula C19H23N5O3, molecular weight 369.4.
It is also registered under: Trimetrexate, 5-甲基-6-(((3,4,5-三甲氧基苯基)氨基)甲基)喹唑啉-2,4-二胺.
Recorded applications: MEDICATION, For use, with concurrent leucovorin administration (leucovorin protection), as an alternative therapy for the treatment of moderate-to-severe <i>Pneumocystis carinii</i> pneumonia (PCP) in immunocompromised patients, including patients with the acquired immunodeficiency syndrome (AIDS). Also used to treat several types of cancer including colon cancer, Lipophilic dihydrofolate reductase structurally related to methotrexate.
Category: Organic Chemicals.
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Independent reference data for Trimetrexate (CAS 52128-35-5), compiled from public chemistry databases.
| CAS Number | 52128-35-5 |
|---|---|
| PubChem CID | 5583 |
| Molecular Formula | C19H23N5O3 |
| IUPAC Name | 5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]quinazoline-2,4-diamine |
| UNII (FDA) | UPN4ITI8T4 |
| Molecular Weight | 369.4 |
|---|---|
| XLogP3 | 2.5 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 8 |
| Rotatable Bond Count | 6 |
| Exact Mass | 369.18008961 |
| Monoisotopic Mass | 369.18008961 |
| Topological Polar Surface Area | 118 |
| Heavy Atom Count | 27 |
| Melting Point | 215-217 °C |
|---|---|
| Melting Point | 215 - 217 °C |
| Solubility | 31.4 |
| Solubility | 3.09e-02 g/L |
| Solubility | Water 1 - 2 (mg/mL) |
| Solubility | 0.1NHC1 1 - 5 (mg/mL) |
| Solubility | 0.1 N NaOH < 1 (mg/mL) |
| Solubility | Methanol 12 - 15 (mg/mL) |
| Solubility | 95% Ethanol 1 - 5 (mg/mL) |
| Solubility | 10% Ethanol 1 - 3 (mg/mL) |
trimetrexate; 52128-35-5; Trimetrexato; Trimetrexatum; NSC-249008; NSC 249008; UPN4ITI8T4; DTXSID3023714; 5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}quinazoline-2,4-diamine; NSC249008; 2,4-Diamino-5-methyl-6-((3,4,5-trimethoxyanilino)methyl)quinazoline; 5-Methyl-6-(((3,4,5-trimethoxyphenyl)amino)methyl)-2,4-quinazolinediamine; 5-methyl-6-(((3,4,5-trimethoxyphenyl)amino)methyl)quinazoline-2,4-diamine; 2,4-Quinazolinediamine, 5-methyl-6-(((3,4,5-trimethoxyphenyl)amino)methyl)-; 5-methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]quinazoline-2,4-diamine; 2,4-diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]quinazoline
Source: PubChem / Wikidata; the batch COA governs where values differ.
Supplier: Jinan Shenghe Chemical Co., Ltd.