tolfenamic acid

Description

tolfenamic acid · CAS 13710-19-5 · C14H12ClNO2. UNII 3G943U18KM. Melting Point: 207ºC; Melting Point: 207 - 207.5 °C; LogP: 5.17.

Identification

CAS Registry Number	13710-19-5
PubChem CID	610479
Molecular formula	C14H12ClNO2
IUPAC name	2-(3-chloro-2-methylanilino)benzoic acid
UNII (FDA)	3G943U18KM

Computed Descriptors

Molecular Weight	261.70
XLogP3	5.2
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Exact Mass	261.0556563
Monoisotopic Mass	261.0556563
Topological Polar Surface Area	49.3
Heavy Atom Count	18
Formal Charge	0

Physical & Chemical Properties

Melting Point	207ºC
Melting Point	207 - 207.5 °C
LogP	5.17
LogP	4.18
Dissociation Constants	5.11

Physical description & handling notes

• Solid
• >39.3 [ug/mL] (The mean of the results at pH 7.4)
• 155.6 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 153.7 Ų [M+H]+ [CCS Type: TW]

GHS Hazard Classification

Reported hazard statements	H301 (95.8%)

Documented Uses

• Pharmaceuticals -> Animal Drugs -> Approved in Taiwan
• In the information for tolfenamic acid, it is stated that this drug, being an NSAID, is effective in treating the pain associated with the acute attack of migraines in adults.
• Compounds capable of relieving pain without the loss of CONSCIOUSNESS.
• Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
• A class of drugs that act by selective inhibition of calcium influx through cellular membranes.
• Compounds that inhibit the action of prostaglandins.

Synonyms

tolfenamic acid; 13710-19-5; Clotam; 2-[(3-Chloro-2-methylphenyl)amino]benzoic Acid; 2-((3-Chloro-2-methylphenyl)amino)benzoic acid; Acido tolfenamico; Acide tolfenamique; N-(3-Chloro-2-methylphenyl)anthranilic acid; Acidum tolfenamicum; N-(3-Chloro-o-tolyl)anthranilic acid; N-(2-Methyl-3-chlorophenyl)anthranilic acid; DTXSID1045409; N-(3-Chloro-o-tolyl)-anthranilic acid; NSC-757873; N-(3-chloro-o-tolyl)anthranilic; 3G943U18KM

Frequently Asked Questions

What are the CAS number and molecular formula of tolfenamic acid?

CAS 13710-19-5; molecular formula C14H12ClNO2; molecular weight — g/mol.

What other names is tolfenamic acid known by?

tolfenamic acid, 13710-19-5, Clotam, 2-[(3-Chloro-2-methylphenyl)amino]benzoic Acid, 2-((3-Chloro-2-methylphenyl)amino)benzoic acid, Acido tolfenamico.

Is tolfenamic acid classified as hazardous?

Hazard statements reported: H301.

What are the key physical properties of tolfenamic acid?

Melting Point: 207ºC; Melting Point: 207 - 207.5 °C; LogP: 5.17; LogP: 4.18.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.