Tipranavir

Description

Tipranavir · CAS 174484-41-4 · C31H33F3N2O5S. UNII ZZT404XD09. Melting Point: 86-89 °C; LogP: 6.9.

Identification

CAS Registry Number	174484-41-4
PubChem CID	54682461
Molecular formula	C31H33F3N2O5S
IUPAC name	N-[3-[(1R)-1-[(2R)-4-hydroxy-6-oxo-2-(2-phenylethyl)-2-propyl-3H-pyran-5-yl]propyl]phenyl]-5-(trifluoromethyl)pyridine-2-sulfonamide
UNII (FDA)	ZZT404XD09

Computed Descriptors

Molecular Weight	602.7
XLogP3	7
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	11
Exact Mass	602.20622782
Monoisotopic Mass	602.20622782
Topological Polar Surface Area	114
Heavy Atom Count	42
Formal Charge	0

Physical & Chemical Properties

Melting Point	86-89 °C
LogP	6.9

Physical description & handling notes

• White solid from ethyl acetate + heptane
• Insoluble
• Freely soluble in dehydrated alcohol, propylene glycol. Insoluble in aqueous buffer, pH 7.5
• Specific optical rotation (in ethanol): +20 deg at 25 °C/D
• Oral: Capsules 250 mg, Aptivus (Boehringer Ingelheim); Solution: 100 mg/mL, Aptivus (Boehringer Ingelheim)

GHS Hazard Classification

Reported hazard statements	H411 (100%)

Documented Uses

• Use (kg; approx.) in Germany (2009): >50
• Consumption (g per capita; approx.) in Germany (2009): 0.000611
• Preparation: K.R. Romines et al., WO 9530670 (1995 to Upjohn); eidem, US 5852195 (1998 to Pharmacia & Upjohn)
• For combination antiretroviral treatment of HIV-1 infected adult patients with evidence of viral replication, who are highly treatment-experienced or have HIV-1 strains resistant to multiple protease inhibitors.
• Breast Feeding; Lactation; Milk, Human; Anti-Infective Agents; Antiviral Agents; Anti-HIV Agents; Anti-Retroviral Agents; HIV Protease Inhibitors
• Tipranavir (brand name: Aptivus) is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV in adults and children weighing at least 79 lb (36 kg) and who meet specific requirements, as determined by a health care provider.

Synonyms

Tipranavir; 174484-41-4; PNU-140690; U-140690; DTXSID6048622; CHEBI:63628; ZZT404XD09; DTXCID9028548; tipranavirum; RefChem:58436; tipranavir, (R-(R*,R*))-; J05AE09; 629-839-6; Aptivus; Tipranavir (INN); HSDB 8083

Frequently Asked Questions

What are the CAS number and molecular formula of Tipranavir?

CAS 174484-41-4; molecular formula C31H33F3N2O5S; molecular weight — g/mol.

What other names is Tipranavir known by?

Tipranavir, 174484-41-4, PNU-140690, U-140690, DTXSID6048622, CHEBI:63628.

Is Tipranavir classified as hazardous?

Hazard statements reported: H411.

What are the key physical properties of Tipranavir?

Melting Point: 86-89 °C; LogP: 6.9.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.