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Tipifarnib

CAS 192185-72-1C27H22Cl2N4OMW 489.4

Tipifarnib (CAS No. 192185-72-1) is supplied by Jinan Shenghe Chemical Co., Ltd. with a typical purity of 按批次COA提供(不公开发布). Main applications include Organic Chemicals. Bulk quantities are available with COA; purity and packaging are subject to batch COA and order confirmation.

Product Overview

CAS Number192185-72-1
Molecular FormulaC27H22Cl2N4O
Molecular Weight489.4
LogP4.1
Purity按批次COA提供(不公开发布)
Packaging按订单/批次确认(不公开发布)
ApplicationsOrganic Chemicals
CategoryOrganic Chemicals

Applications

Organic Chemicals

Packaging & Storage

Packaging按订单/批次确认(不公开发布)
Purity按批次COA提供(不公开发布)
StorageSealed, cool and dry place
ShippingStandard chemical transport
SampleAvailable on request
Lead TimeIn stock / per order

Quality & Documentation

COA (Certificate of Analysis) is provided with every batch. MSDS/technical data sheets and third-party test reports are available on request. Purity and packaging are subject to batch COA and order confirmation.

Frequently Asked Questions

What is the CAS number of Tipifarnib?

The CAS number of Tipifarnib is 192185-72-1.

What purity and packaging are available?

Typical purity is 按批次COA提供(不公开发布), supplied in 按订单/批次确认(不公开发布), with COA provided.

What are the applications of Tipifarnib?

Main applications include Organic Chemicals.

How do I buy Tipifarnib or get a quote?

Email info@591daili.com or reach us on WhatsApp with the product name, CAS number and required quantity; quotes within one business day. Supplier: Jinan Shenghe Chemical Co., Ltd..

PubChem Public Data

Description

Tipifarnib · CAS 192185-72-1 · C27H22Cl2N4O. UNII MAT637500A.

Identification

CAS Registry Number192185-72-1
PubChem CID159324
Molecular formulaC27H22Cl2N4O
IUPAC name6-[(R)-amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chlorophenyl)-1-methylquinolin-2-one
UNII (FDA)MAT637500A

Computed Descriptors

Molecular Weight489.4
XLogP34.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass488.1170667
Monoisotopic Mass488.1170667
Topological Polar Surface Area64.2
Heavy Atom Count34
Formal Charge0

Physical description & handling notes

  • R115777, a nonpeptidomimetic farnesyl transferase inhibitor, suppresses the growth of human pancreatic adenocarcinoma cell lines. This growth inhibition is associated with modulation in the phosphorylation levels of signal transducers and activators of transcription 3 (STAT3) and extracellular signal-regulated kinases (ERK).

GHS Hazard Classification

Reported hazard statementsH302 (33.3%), H315 (100%), H319 (100%), H335 (66.7%), H373 (33.3%)

H302 (33.3%): Harmful if swallowed [Warning Acute toxicity, oral]

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]

Documented Uses

  • Investigated for use/treatment in colorectal cancer, leukemia (myeloid), pancreatic cancer, and solid tumors.
  • Substances that inhibit or prevent the proliferation of NEOPLASMS.

Synonyms

Tipifarnib; 192185-72-1; Zarnestra; R-115777; (R)-6-(Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone; tipifarnibum; R-11577; NSC-702818; 6-[(R)-amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chlorophenyl)-1-methylquinolin-2-one; MAT637500A; DTXSID5041140; CHEBI:141969; NSC702818; (R)-6-[Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone; 6-((R)-amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl)-4-(3-chlorophenyl)-1-methylquinolin-2-one; RefChem:898221

Frequently Asked Questions

What are the CAS number and molecular formula of Tipifarnib?

CAS 192185-72-1; molecular formula C27H22Cl2N4O; molecular weight — g/mol.

What other names is Tipifarnib known by?

Tipifarnib, 192185-72-1, Zarnestra, R-115777, (R)-6-(Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone, tipifarnibum.

Is Tipifarnib classified as hazardous?

Hazard statements reported: H302, H315, H319, H335, H373.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.

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