Telavancin

Description

Telavancin · CAS 372151-71-8 · C80H106Cl2N11O27P. UNII XK134822Z0.

Identification

Computed Descriptors

Physical description & handling notes

• Off-white to slightly colored amorphous powder; highly lipophilic and slightly soluble in water /Telavancin hydrochloride/
• Table: Telavancin Hydrochloride Preparations [Table#8173]

Documented Uses

• Telavancin is a semi-synthetic substance derived from the glycopeptide vancomycin by a two-step synthesis followed by purification and isolation. Telavancin contains a lipophilic side chain bond to the amino sugar of vancomycin and an aminomethyl phosphonite group bond to the di-phenol-ring of vancomycin.
• Preparation: M. R. Leadbetter, M. S. Linsell, World Intellectual Property Organization patent 0198328; eidem, United States of America patent 6635618 (2001, 2003 both to Advanced Medicine). Manufacturing process: M. Leadbetter et al., World Intellectual Property Organization patent 03029270 (2001 to Theravance).
• Synthetic derivative of vancomycin
• Breast Feeding; Lactation; Milk, Human; Anti-Infective Agents; Antibacterial Agents; Glycopeptides; Lipoglycopeptides
• Vibativ is indicated for the treatment of adult patients with complicated skin and skin structure infections (cSSSI) caused by susceptible isolates of the following Gram-positive microorganisms: Staphylococcus aureus (including methicillin-susceptible and -resistant isolates), Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus anginosus group (includes S. anginosus, S. intermedius, and S. constellatus), or Enterococcus faecalis (vancomycin-susceptible isolates only). /Included in US product label/
• Vibativ is indicated for the treatment of adult patients with hospital-acquired and ventilator associated bacterial pneumonia (HABP/VABP), caused by susceptible isolates of 45 Staphylococcus aureus (including methicillin-susceptible and -resistant isolates). Vibativ 46 should be reserved for use when alternative treatments are not suitable. /Included in US product label/

Synonyms

Telavancin; 372151-71-8; telavancina; telavancine; Televancin; telavancinum; XK134822Z0; CHEBI:71229; DTXSID10873383; TD6424; Vancomycin, N3''-(2-(decylamino)ethyl)-29-(((phosphonomethyl)amino)methyl)-; VANCOMYCIN, N(SUP 3'')-(2-(DECYLAMINO)ETHYL)-29-(((PHOSPHONOMETHYL)AMINO)METHYL)-; RefChem:56919; DTXCID80820900; J01XA03; 927-282-6

Frequently Asked Questions

What are the CAS number and molecular formula of Telavancin?

CAS 372151-71-8; molecular formula C80H106Cl2N11O27P; molecular weight — g/mol.

What other names is Telavancin known by?

Telavancin, 372151-71-8, telavancina, telavancine, Televancin, telavancinum.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.