SUBTILISINS (CAS 1395-21-7) — formula C45H68N10O15, molecular weight 989.1; category organic chemicals.
| CAS Number | 1395-21-7 |
|---|---|
| Molecular Formula | C45H68N10O15 |
| Molecular Weight | 989.1 |
| LogP | -1.1 |
| Applications | Uses: Commercial proteolytic enzymes are used in laundry detergents, [NIOSH] Proteolytic enzymes from Bacillus subtilis were first used in detergent products in the 1960s. [Malo], A commercial raw proteolytic enzyme, Laundry detergent and automatic dishwashing for removal of proteinaceous stains. Animal feed for improved digestibility of proteins in animal feed. New industrial use for membrane cleaning, Subtilisin A is a member of the Serine S8 Endoproteinase family. It has broad specificity with a preference for a large uncharged residue in the P1 position. It hydrolyzes native and denatured proteins, and is active under alkaline conditions., Used in automatic dish wash detergents ... all types of powder and liquid household laundry detergents in laundry bleaches ... also used in industrial cleaning and laundering products ... used in protein hydrolysate production, leather treatment, and in textile and cosmetics industry, For more Uses (Complete) data for Subtilisins (7 total), please visit the HSDB record page., Use Classification: EPA Safer Chemical Functional Use Classes -> Enzymes and Enzyme Stabilizers, Safer Chemical Classes -> Yellow triangle - The chemical has met Safer Choice Criteria for its functional ingredient-class, but has some hazard profile issues, Cosmetics -> Skin conditioning, Household Products: Cosmetics product ingredient: Subtilisin, Product count: 2, Information on 2 consumer products that contain Bacillomycin in the following categories is provided:, • Inside the Home, Information on 447 consumer products that contain Subtilisin (proteolytic enzyme) in the following categories is provided:, • Auto Products, • Commercial, Institutional, • Home Maintenance, • Personal Care, Methods of Manufacturing: Subtilisins are produced from fermentation of Bacillus licheniformis., Formulations, Preparations: Subtilisin A (Prod Code P5380) is supplied as a powder, essentially free of buffer salts., Alcalase 2.4L (Prod Code P4860) is supplied as an aqueous solution., U.S. Production: Total amount used and produced in the European Union in 2002 approximately 1, 000 tons pure enzyme, General Manufacturing Information: Subtilisin: ACTIVE, A serine endopeptidase isolated from Bacillus subtilis. It hydrolyzes proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. It also hydrolyzes peptide amides., Activity Determination and Optimal Conditions. Unit definition: One Sigma Unit will hydrolyze casein to produce color equivalent to 1.0 mmole (181 ug) of tyrosine per minute at pH 7.5 at 37 °C (color by Folin-Ciocalteu reagent). The activity Alcalase is reported in Anson units. (One Anson unit is defined as the amount of enzyme which, under specified conditions, digests urea-denatured hemoglobin at an initial rate such that there is liberated an amount of TCA-soluble product per minute which gives the same color with Folin-Ciocalteu Phenol reagent as one milliequivalent of tyrosine at 25 °C at pH 7.50.) Based on average values, one Anson unit = 370 Sigma units., The gene encoding subtilisin Carlsberg from Bacillus licheniformis has been isolated by molecular cloning using a mixture of synthetic oligonucleotides. The entire nucleotide sequence of the coding sequence as well as 5' and 3' flanking sequences have been determined. The deduced amino acid sequence reveals an N-terminal signal peptide consisting of 29 residues, a pro-peptide of 76 residues followed by the mature protein comprising 274 residues. The ATG initiator codon is proceeded by two putitative overlapping ribosomal binding sequences. A palindromic sequence typical for transcription termination is found downstream from the TAA stop codon. Structural comparisons between different known subtilisin genes reveal extensive homology, particularly in the parts coding for the pro-region and the mature protein. Expression studies in Bacillus subtilis show that the cloned fragment produces a functional enzyme when inserted after a B. subtilis promoter., Subtilisin Carlsberg, For more General Manufacturing Information (Complete) data for Subtilisins (7 total) |
| Category | Organic Chemicals |
Documented applications: Uses: Commercial proteolytic enzymes are used in laundry detergents, [NIOSH] Proteolytic enzymes from Bacillus subtilis were first used in detergent products in the 1960s. [Malo], A commercial raw proteolytic enzyme, Laundry detergent and automatic dishwashing for removal of proteinaceous stains. Animal feed for improved digestibility of proteins in animal feed. New industrial use for membrane cleaning, Subtilisin A is a member of the Serine S8 Endoproteinase family. It has broad specificity with a preference for a large uncharged residue in the P1 position. It hydrolyzes native and denatured proteins, and is active under alkaline conditions., Used in automatic dish wash detergents ... all types of powder and liquid household laundry detergents in laundry bleaches ... also used in industrial cleaning and laundering products ... used in protein hydrolysate production, leather treatment, and in textile and cosmetics industry, For more Uses (Complete) data for Subtilisins (7 total), please visit the HSDB record page., Use Classification: EPA Safer Chemical Functional Use Classes -> Enzymes and Enzyme Stabilizers, Safer Chemical Classes -> Yellow triangle - The chemical has met Safer Choice Criteria for its functional ingredient-class, but has some hazard profile issues, Cosmetics -> Skin conditioning, Household Products: Cosmetics product ingredient: Subtilisin, Product count: 2, Information on 2 consumer products that contain Bacillomycin in the following categories is provided:, • Inside the Home, Information on 447 consumer products that contain Subtilisin (proteolytic enzyme) in the following categories is provided:, • Auto Products, • Commercial, Institutional, • Home Maintenance, • Personal Care, Methods of Manufacturing: Subtilisins are produced from fermentation of Bacillus licheniformis., Formulations, Preparations: Subtilisin A (Prod Code P5380) is supplied as a powder, essentially free of buffer salts., Alcalase 2.4L (Prod Code P4860) is supplied as an aqueous solution., U.S. Production: Total amount used and produced in the European Union in 2002 approximately 1, 000 tons pure enzyme, General Manufacturing Information: Subtilisin: ACTIVE, A serine endopeptidase isolated from Bacillus subtilis. It hydrolyzes proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. It also hydrolyzes peptide amides., Activity Determination and Optimal Conditions. Unit definition: One Sigma Unit will hydrolyze casein to produce color equivalent to 1.0 mmole (181 ug) of tyrosine per minute at pH 7.5 at 37 °C (color by Folin-Ciocalteu reagent). The activity Alcalase is reported in Anson units. (One Anson unit is defined as the amount of enzyme which, under specified conditions, digests urea-denatured hemoglobin at an initial rate such that there is liberated an amount of TCA-soluble product per minute which gives the same color with Folin-Ciocalteu Phenol reagent as one milliequivalent of tyrosine at 25 °C at pH 7.50.) Based on average values, one Anson unit = 370 Sigma units., The gene encoding subtilisin Carlsberg from Bacillus licheniformis has been isolated by molecular cloning using a mixture of synthetic oligonucleotides. The entire nucleotide sequence of the coding sequence as well as 5' and 3' flanking sequences have been determined. The deduced amino acid sequence reveals an N-terminal signal peptide consisting of 29 residues, a pro-peptide of 76 residues followed by the mature protein comprising 274 residues. The ATG initiator codon is proceeded by two putitative overlapping ribosomal binding sequences. A palindromic sequence typical for transcription termination is found downstream from the TAA stop codon. Structural comparisons between different known subtilisin genes reveal extensive homology, particularly in the parts coding for the pro-region and the mature protein. Expression studies in Bacillus subtilis show that the cloned fragment produces a functional enzyme when inserted after a B. subtilis promoter., Subtilisin Carlsberg, For more General Manufacturing Information (Complete) data for Subtilisins (7 total).
SUBTILISINS is a carbon-based organic compound with CAS registry number 1395-21-7 and molecular formula C45H68N10O15 (molecular weight 989.1), belonging to the organic chemicals segment of chemical raw materials.
CAS number: 1395-21-7
Its molecular formula C45H68N10O15 comprises 45 C, 68 H, 10 N, 15 O atoms.
Also known as: SUBTILISINS · 枯草杆菌蛋白酶
Category: organic chemicals
The CAS registry number of SUBTILISINS is 1395-21-7.
Molecular formula C45H68N10O15, molecular weight 989.1.
It is also registered under: SUBTILISINS, 枯草杆菌蛋白酶.
Recorded applications: Uses: Commercial proteolytic enzymes are used in laundry detergents, [NIOSH] Proteolytic enzymes from Bacillus subtilis were first used in detergent products in the 1960s. [Malo], A commercial raw proteolytic enzyme, Laundry detergent and automatic dishwashing for removal of proteinaceous stains. Animal feed for improved digestibility of proteins in animal feed. New industrial use for membrane cleaning, Subtilisin A is a member of the Serine S8 Endoproteinase family. It has broad specificity with a preference for a large uncharged residue in the P1 position. It hydrolyzes native and denatured proteins, and is active under alkaline conditions., Used in automatic dish wash detergents ... all types of powder and liquid household laundry detergents in laundry bleaches ... also used in industrial cleaning and laundering products ... used in protein hydrolysate production, leather treatment, and in textile and cosmetics industry, For more Uses (Complete) data for Subtilisins (7 total), please visit the HSDB record page., Use Classification: EPA Safer Chemical Functional Use Classes -> Enzymes and Enzyme Stabilizers, Safer Chemical Classes -> Yellow triangle - The chemical has met Safer Choice Criteria for its functional ingredient-class, but has some hazard profile issues, Cosmetics -> Skin conditioning, Household Products: Cosmetics product ingredient: Subtilisin, Product count: 2, Information on 2 consumer products that contain Bacillomycin in the following categories is provided:, • Inside the Home, Information on 447 consumer products that contain Subtilisin (proteolytic enzyme) in the following categories is provided:, • Auto Products, • Commercial, Institutional, • Home Maintenance, • Personal Care, Methods of Manufacturing: Subtilisins are produced from fermentation of Bacillus licheniformis., Formulations, Preparations: Subtilisin A (Prod Code P5380) is supplied as a powder, essentially free of buffer salts., Alcalase 2.4L (Prod Code P4860) is supplied as an aqueous solution., U.S. Production: Total amount used and produced in the European Union in 2002 approximately 1, 000 tons pure enzyme, General Manufacturing Information: Subtilisin: ACTIVE, A serine endopeptidase isolated from Bacillus subtilis. It hydrolyzes proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. It also hydrolyzes peptide amides., Activity Determination and Optimal Conditions. Unit definition: One Sigma Unit will hydrolyze casein to produce color equivalent to 1.0 mmole (181 ug) of tyrosine per minute at pH 7.5 at 37 °C (color by Folin-Ciocalteu reagent). The activity Alcalase is reported in Anson units. (One Anson unit is defined as the amount of enzyme which, under specified conditions, digests urea-denatured hemoglobin at an initial rate such that there is liberated an amount of TCA-soluble product per minute which gives the same color with Folin-Ciocalteu Phenol reagent as one milliequivalent of tyrosine at 25 °C at pH 7.50.) Based on average values, one Anson unit = 370 Sigma units., The gene encoding subtilisin Carlsberg from Bacillus licheniformis has been isolated by molecular cloning using a mixture of synthetic oligonucleotides. The entire nucleotide sequence of the coding sequence as well as 5' and 3' flanking sequences have been determined. The deduced amino acid sequence reveals an N-terminal signal peptide consisting of 29 residues, a pro-peptide of 76 residues followed by the mature protein comprising 274 residues. The ATG initiator codon is proceeded by two putitative overlapping ribosomal binding sequences. A palindromic sequence typical for transcription termination is found downstream from the TAA stop codon. Structural comparisons between different known subtilisin genes reveal extensive homology, particularly in the parts coding for the pro-region and the mature protein. Expression studies in Bacillus subtilis show that the cloned fragment produces a functional enzyme when inserted after a B. subtilis promoter., Subtilisin Carlsberg, For more General Manufacturing Information (Complete) data for Subtilisins (7 total).
Category: Organic Chemicals.
Independent reference data for SUBTILISINS (CAS 1395-21-7), compiled from public chemistry databases.
| CAS 号 | 1395-21-7 |
|---|---|
| PubChem CID | 3086051 |
| 分子式 | C45H68N10O15 |
| IUPAC 名称 | 3-[(3R,6R,9S,16S,19R,22S,25S)-3,9-bis(2-amino-2-oxoethyl)-16-[(1R)-1-hydroxyethyl]-19-(hydroxymethyl)-6-[(4-hydroxyphenyl)methyl]-13-octyl-2,5,8,11,15,18,21,24-octaoxo-1,4,7,10,14,17,20,23-octazabicyclo[23.3.0]octacosan-22-yl]propanoic acid |
| Molecular Weight | 989.1 |
|---|---|
| XLogP3 | -1.1 |
| Hydrogen Bond Donor Count | 13 |
| Hydrogen Bond Acceptor Count | 15 |
| Rotatable Bond Count | 18 |
| Exact Mass | 988.48656150 |
| Monoisotopic Mass | 988.48656150 |
| Topological Polar Surface Area | 408 |
| Heavy Atom Count | 70 |
| Vapor Pressure | 0 mmHg (approx) |
|---|
杆菌霉素； 9014-01-1；枯草杆菌蛋白酶； ALK-酶；碱性酶；生物普拉斯；埃斯特雷克斯；真菌素；基因酶；纳加瑟；杆菌霉素R；枯草杆菌蛋白酶BPN；枯草杆菌蛋白酶NOVO；杆菌肽酶A；杆菌肽酶B；枯草杆菌蛋白酶 Carlsburg（注：商业蛋白水解酶用于洗衣粉中。）
| 法规与食品接触 | CIR / INCI: Cosmetics ingredient -> Other (Specify) CIR / INCI: Skin conditioning |
|---|---|
| GHS 通报统计 | 0.5% (11 / 2113) |
| GHS 通报统计 | 0.5% (11 / 2113) |
|---|---|
| 已通报的危害声明 | H315, H318, H334, H335, H302 (15.4%), H400 (15.4%), H411 (11.4%), H410 |
枯草杆菌蛋白酶 · CAS 1395-21-7 · C45H68N10O15. Vapor Pressure: 0 mmHg (approx).
Source: PubChem / Wikidata; the batch COA governs where values differ.
Supplier: Jinan Shenghe Chemical Co., Ltd.
中文页面: 枯草杆菌蛋白酶