Streptozocin

Description

Streptozocin · CAS 66395-18-4 · C8H15N3O7. UNII 8H27GUR065. Melting Point: 115; Melting Point: 115 °C; Solubility: 5070.

Identification

CAS Registry Number	66395-18-4
PubChem CID	29327
Molecular formula	C8H15N3O7
IUPAC name	1-methyl-1-nitroso-3-[(2S,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]urea
UNII (FDA)	8H27GUR065

Computed Descriptors

Molecular Weight	265.22
XLogP3	-1.4
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	2
Exact Mass	265.09099983
Monoisotopic Mass	265.09099983
Topological Polar Surface Area	152
Heavy Atom Count	18
Formal Charge	0

Physical & Chemical Properties

Melting Point	115
Melting Point	115 °C
Solubility	5070
Solubility	3.35e+01 g/L
LogP	-1.45
LogP	-1.7
Dissociation Constants	pKa= 1.35

Physical description & handling notes

• Streptozocin is an off-white powder. Melting point 115 °C. Used as an anti-cancer drug. Carcinogenic.
• Ivory-colored or pale yellow solid; [HSDB] Light yellow crystalline solid; [MSDSonline]
• Solid
• POINTED PLATELETS OR PRISMS FROM 95% ETHANOL
• PALE-YELLOW CRYSTALS
• Ivory-colored crystalline powder

Regulatory Status

GHS notification summary	1.8% (1 / 57)

GHS Hazard Classification

GHS notification summary	1.8% (1 / 57)
Reported hazard statements	H312 (22.8%), H332 (22.8%), H340 (22.8%), H350 (96.5%), H360 (22.8%), H301, H341, H351

Documented Uses

• Produced by Streptomyces achromogenas (soil microorganisms); Used to produce diabetes in experimental animals and as an antineoplastic agent; [HSDB]
• EMPLOYED AS DIABETOGENIC AGENT IN EXPERIMENTAL ANIMALS.
• PRODUCTION OF EXPTL DIABETES IN LAB ANIMALS; ANTINEOPLASTIC.
• For the treatment of malignant neoplasms of pancreas (metastatic islet cell carcinoma).
• PURIFICATION FROM STREPTOMYCES ACHROMOGENES CULTURES; SYNTHESIS FROM TETRA-O-ACETYL GLUCOSAMINE HYDROCHLORIDE; REACTION OF D-GLUCOSAMINE WITH N-NITROSOMETHYLCARBAMYLAZIDE OR N-METHYLISOCYANATE.
• ISOLATION FROM STREPTOMYCES ACHROMOGENES FERMENTATION BROTH.

Synonyms

streptozocin; STREPTOZOTOCIN; 18883-66-4; Streptozocinium; Streptozocinum; STRZ; Streptozoticin; Streptozocinium [Latin]; DTXSID2021282; N-D-Glucosyl-(2)-N'-nitrosomethylurea; CHEBI:9288; N-D-Glucosyl-(2)-N'-nitrosomethylharnstoff; 3-methyl-3-nitroso-1-[(2S,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]urea; 2-Deoxy-2-(((methylnitrosoamino)carbonyl)amino)-D-glucopyranose; 2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose; 1-methyl-1-nitroso-3-[(2S,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]urea

Frequently Asked Questions

What are the CAS number and molecular formula of Streptozocin?

CAS 66395-18-4; molecular formula C8H15N3O7; molecular weight — g/mol.

What other names is Streptozocin known by?

streptozocin, STREPTOZOTOCIN, 18883-66-4, Streptozocinium, Streptozocinum, STRZ.

Is Streptozocin classified as hazardous?

1.8% of GHS notifications report no hazard classification (1 of 57).

What are the key physical properties of Streptozocin?

Melting Point: 115; Melting Point: 115 °C; Solubility: 5070; Solubility: 3.35e+01 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.