Sertindole

Description

Sertindole · CAS 106516-24-9 · C24H26ClFN4O. UNII GVV4Z879SP. Solubility: 9.63e-03 g/L.

Identification

CAS Registry Number	106516-24-9
PubChem CID	60149
Molecular formula	C24H26ClFN4O
IUPAC name	1-[2-[4-[5-chloro-1-(4-fluorophenyl)indol-3-yl]piperidin-1-yl]ethyl]imidazolidin-2-one
UNII (FDA)	GVV4Z879SP

Computed Descriptors

Molecular Weight	440.9
XLogP3	4.1
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	5
Exact Mass	440.1779173
Monoisotopic Mass	440.1779173
Topological Polar Surface Area	40.5
Heavy Atom Count	31
Formal Charge	0

Physical & Chemical Properties

Solubility	9.63e-03 g/L

Physical description & handling notes

• Solid
• 215.9 Ų [M+H]+ [CCS Type: TW; Method: Major Mix IMS/Tof Calibration Kit (Waters)]
• Sertindole is an atypical antipsychotic at least as effective as haloperidol and risperidone in the treatment of neuroleptic-responsive schizophrenia. Sertindole improves negative symptoms, and is also effective for the treatment of neuroleptic-resistant schizophrenia. Sertindole is generally well tolerated and is associated with a low rate of extrapyramidal symptoms (EPS).

GHS Hazard Classification

Reported hazard statements	H315 (95.2%), H319 (95.2%), H335 (92.9%), H413 (92.9%)

Documented Uses

• Used in the treatment of schizophrenia.
• Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus.
• Hepatic. Sertindole is metabolized by cytochrome P450 isoenzymes CYP 2D6 and CYP 3A4.
• Sertindole has known human metabolites that include 1-[2-[4-[5-Chloro-1-(4-fluorophenyl)indol-3-yl]piperidin-1-yl]ethyl]-4-hydroxyimidazolidin-2-one and 5-Chloro-1-(4-fluorophenyl)-3-(piperidin-4-yl)-1H-indole.
• Sertindole is an antipsychotic drug with affinity for dopamine D2, serotonin 5-HT2A and 5-HT2C, and alpha1-adrenoreceptors. Preclinical studies suggest that sertindole acts preferentially on limbic and cortical dopaminergic neurons and clinical trials have confirmed that sertindole is effective at a low dopamine D2 occupancy level.

Synonyms

SERTINDOLE; 106516-24-9; SerLect; Serdolect; Sertindol; Sertindolum; Lu 23-174; zerdol; Lu-23-174; 1-[2-[4-[5-chloro-1-(4-fluorophenyl)indol-3-yl]piperidin-1-yl]ethyl]imidazolidin-2-one; DTXSID6048967; 1-(2-{4-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl]piperidin-1-yl}ethyl)imidazolidin-2-one; GVV4Z879SP; 1-(2-(4-(5-Chloro-1-(4-fluorophenyl)-1H-indol-3-yl)piperidin-1-yl)ethyl)imidazolidin-2-one; CHEBI:9122; DTXCID3028893

Frequently Asked Questions

What are the CAS number and molecular formula of Sertindole?

CAS 106516-24-9; molecular formula C24H26ClFN4O; molecular weight — g/mol.

What other names is Sertindole known by?

SERTINDOLE, 106516-24-9, SerLect, Serdolect, Sertindol, Sertindolum.

Is Sertindole classified as hazardous?

Hazard statements reported: H315, H319, H335, H413.

What are the key physical properties of Sertindole?

Solubility: 9.63e-03 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.