sennoside A

Description

5,5'-bis(β-C-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-10,10'-dioxo[9,9'-bianthracene]-2,2'-dicarboxylic acid · CAS 81-27-6 · C42H38O20. UNII CAREMOTION.

Identification

CAS Registry Number	81-27-6
PubChem CID	5199
Molecular formula	C42H38O20
IUPAC name	9-[2-carboxy-4-hydroxy-10-oxo-5-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracen-9-yl]-4-hydroxy-10-oxo-5-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracene-2-carboxylic acid
UNII (FDA)	CAREMOTION

Computed Descriptors

Molecular Weight	862.7
XLogP3	1.2
Hydrogen Bond Donor Count	12
Hydrogen Bond Acceptor Count	20
Rotatable Bond Count	9
Exact Mass	862.19564360
Monoisotopic Mass	862.19564360
Topological Polar Surface Area	348
Heavy Atom Count	62
Formal Charge	0

Physical description & handling notes

• Senna stimulates peristalsis and increases fecal water content to increase motility of feces through the large intestine.

Regulatory Status

Regulatory & Food Contact	CIR / INCI: Skin conditioning
GHS notification summary	66.7% (2 / 3)

GHS Hazard Classification

GHS notification summary	66.7% (2 / 3)
Reported hazard statements	H317 (100%), H334 (100%), H302 (33.3%)

Documented Uses

• For the over the counter treatment of constipation.
• Avoid natural licorice. Licorice root can induce hypokalemia in patients taking sennosides.
• Agents that produce a soft formed stool, and relax and loosen the bowels, typically used over a protracted period, to relieve CONSTIPATION.
• A - Alimentary tract and metabolism
• QA - Alimentary tract and metabolism
• <10% is absorbed from the gut mostly in the form of the active metabolite rheinanthrone [DB13175].

Synonyms

Sennosides; Glysennid; Laxative; Sennoside Ca; Colonorm; Nytilax; Sankaijo; Exchange select; Docuset Sodium; Laxative Pills; Laxative Senna; Senna Glycoside; Colistat Plus; Gentle Nature; Senna Liquid; Colon Detox

Frequently Asked Questions

What are the CAS number and molecular formula of 5,5'-bis(β-C-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-10,10'-dioxo[9,9'-bianthracene]-2,2'-dicarboxylic acid?

CAS 81-27-6; molecular formula C42H38O20; molecular weight — g/mol.

What other names is 5,5'-bis(β-C-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-10,10'-dioxo[9,9'-bianthracene]-2,2'-dicarboxylic acid known by?

Sennosides, Glysennid, Laxative, Sennoside Ca, Colonorm, Nytilax.

What is the regulatory status of 5,5'-bis(β-C-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-10,10'-dioxo[9,9'-bianthracene]-2,2'-dicarboxylic acid?

Documented regulatory listings: CIR / INCI: Skin conditioning.

Is 5,5'-bis(β-C-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-10,10'-dioxo[9,9'-bianthracene]-2,2'-dicarboxylic acid classified as hazardous?

66.7% of GHS notifications report no hazard classification (2 of 3).

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.