Salmeterol

Description

Salmeterol · CAS 89365-50-4 · C25H37NO4. UNII 2I4BC502BT. Boiling Point: 603; Melting Point: 75.5-76.5 °C; Melting Point: 75.7-76.5 °C.

Identification

CAS Registry Number	89365-50-4
PubChem CID	5152
Molecular formula	C25H37NO4
IUPAC name	2-(hydroxymethyl)-4-[1-hydroxy-2-[6-(4-phenylbutoxy)hexylamino]ethyl]phenol
UNII (FDA)	2I4BC502BT

Computed Descriptors

Molecular Weight	415.6
XLogP3	3.9
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	16
Exact Mass	415.27225866
Monoisotopic Mass	415.27225866
Topological Polar Surface Area	82
Heavy Atom Count	30
Formal Charge	0

Physical & Chemical Properties

Boiling Point	603
Melting Point	75.5-76.5 °C
Melting Point	75.7-76.5 °C
Melting Point	75.5 - 76.5 °C
Solubility	2.26e-03 g/L
LogP	4.2

Physical description & handling notes

• Solid
• Sparingly soluble
• 1.9X10-15 mm Hg at 25 °C /Estimated/
• log Kow = 4.15 /Estimated/
• Henry's Law constant = 2.5X10-17 atm-cu m/mol at 25 °C /Estimated/
• Salmeterol xinafoate oral inhalation aerosol or oral inhalation powder (Serevent Diskus) is stable for 2 years or 18 months, respectively, from the date of manufacture.

GHS Hazard Classification

Reported hazard statements	H302 (50%), H315 (100%), H317 (50%), H319 (100%), H412 (50%)

Documented Uses

• Anti-asthmatic /Xinafoate salt/
• Salmeterol ... /is/ indicated as bronchodilators for the treatment of bronchospasm associated with chronic obstructive airway disease, including bronchitis and pulmonary emphysema. ... /Included in US product labeling/
• Use (kg; approx.) in Germany (2009): >10
• Consumption (g per capita; approx.) in Germany (2009): 0.000122
• Consumption (g per capita) in the USA (2002): 0.24
• For the treatment of asthma and chronic obstructive pulmonary disease (COPD).

Synonyms

Salmeterol; 89365-50-4; 2-(hydroxymethyl)-4-[1-hydroxy-2-[6-(4-phenylbutoxy)hexylamino]ethyl]phenol; Salmeterolum; GR 33343X; SALMATEROL; SN408D; DTXSID6023571; GR 33343 X; 2I4BC502BT; GR-33343-X; DTXCID803571; 4-(1-hydroxy-2-((6-(4-phenylbutoxy)hexyl)amino)ethyl)-2-(hydroxymethyl)phenol; 4-(1-hydroxy-2-{[6-(4-phenylbutoxy)hexyl]amino}ethyl)-2-(hydroxymethyl)phenol; Neovent; Soltel

Frequently Asked Questions

What are the CAS number and molecular formula of Salmeterol?

CAS 89365-50-4; molecular formula C25H37NO4; molecular weight — g/mol.

What other names is Salmeterol known by?

Salmeterol, 89365-50-4, 2-(hydroxymethyl)-4-[1-hydroxy-2-[6-(4-phenylbutoxy)hexylamino]ethyl]phenol, Salmeterolum, GR 33343X, SALMATEROL.

Is Salmeterol classified as hazardous?

Hazard statements reported: H302, H315, H317, H319, H412.

What are the key physical properties of Salmeterol?

Boiling Point: 603; Melting Point: 75.5-76.5 °C; Melting Point: 75.7-76.5 °C; Melting Point: 75.5 - 76.5 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.