Ropinirole

Description

Ropinirole · CAS 91374-21-9 · C16H24N2O. UNII 030PYR8953. Boiling Point: 410.5±45.0 °C at 760 mmHg; Melting Point: 243-250 °C; Melting Point: 243 - 250 °C.

Identification

CAS Registry Number	91374-21-9
PubChem CID	5095
Molecular formula	C16H24N2O
IUPAC name	4-[2-(dipropylamino)ethyl]-1,3-dihydroindol-2-one
UNII (FDA)	030PYR8953

Computed Descriptors

Molecular Weight	260.37
XLogP3	2.7
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	7
Exact Mass	260.188863393
Monoisotopic Mass	260.188863393
Topological Polar Surface Area	32.3
Heavy Atom Count	19
Formal Charge	0

Physical & Chemical Properties

Boiling Point	410.5±45.0 °C at 760 mmHg
Melting Point	243-250 °C
Melting Point	243 - 250 °C
Solubility	133
Solubility	3.53e-01 g/L
LogP	3.06
LogP	log Kow = 2.70
LogP	2.3
LogP	2.84
Dissociation Constants	10.17

Physical description & handling notes

• Solid
• Stable under recommended storage conditions. /Ropinirole hydrochloride/
• 163.27 Ų [M+K]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 159.22 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 161.49 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 162.5 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

GHS Hazard Classification

Reported hazard statements	H302 (100%), H412 (100%), H400, H410

Documented Uses

• Antiparkinson Agents; Dopamine Agonists
• Use (kg; approx.) in Germany (2009): >75
• Consumption (g per capita; approx.) in Germany (2009): 0.000916
• For the treatment of the signs and symptoms of idiopathic Parkinson's disease. Also used for the treatment of restless legs syndrome.
• Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
• Preparation: G. Gallagher, Jr., United States of America patent 4452808 (1984 to SmithKline Beckman)

Synonyms

ropinirole; 91374-21-9; ropinirol; Ropinirolum; Ropitor; SKF 101468; SK&F 101468; Narapin; DTXSID8045195; 4-[2-(dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one; NSC-758917; 030PYR8953; SK&F-101468; CHEBI:8888; DTXCID6025195; Adartrel

Frequently Asked Questions

What are the CAS number and molecular formula of Ropinirole?

CAS 91374-21-9; molecular formula C16H24N2O; molecular weight — g/mol.

What other names is Ropinirole known by?

ropinirole, 91374-21-9, ropinirol, Ropinirolum, Ropitor, SKF 101468.

Is Ropinirole classified as hazardous?

Hazard statements reported: H302, H412, H400, H410.

What are the key physical properties of Ropinirole?

Boiling Point: 410.5±45.0 °C at 760 mmHg; Melting Point: 243-250 °C; Melting Point: 243 - 250 °C; Solubility: 133.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.