Reboxetine

Description

Reboxetine · CAS 71620-89-8 · C19H23NO3. UNII 947S0YZ36I. Melting Point: 170-171 °C (Mesylate salt); Melting Point: 170-171 °C; LogP: 3.1.

Identification

Computed Descriptors

Physical & Chemical Properties

Physical description & handling notes

• Solubility: greater than 5 mg/mL in water /Mesylate/
• 174 Ų [M+H]+ [CCS Type: TW; Method: Major Mix IMS/Tof Calibration Kit (Waters)]
• Reboxetine is a selective noradrenaline reuptake inhibitor (NaRI), the first drug of new antidepressant class. Reboxetine is an a-ariloxybenzyl derivative of morpholine. Reboxetine is primarily used to treat depression but has also been found useful in the treatment of narcolepsy and panic disorders.
• Oral: 4 mg tablets Edronax (Pharmacia Limited, United Kingdom)

Documented Uses

• Selective noradrenaline reuptake inhibitor
• Reboxetine is an antidepressant drug used in the treatment of clinical depression, panic disorder and Attention Deficit Disorder/Attention Deficit Hyperactivity Disorder (ADD/ADHD).
• Use (kg; approx.) in Germany (2009): >75
• Consumption (g per capita; approx.) in Germany (2009): 0.000916
• For the treatment of clinical depression.
• Preparation: P. Melloni at al., DE 2901032; eidem, US 4229449 (1979, 1980 both to Farrmitalia Carlo Erba)

Synonyms

Reboxetine; 71620-89-8; 947S0YZ36I; Morpholine, 2-((R)-(2-ethoxyphenoxy)phenylmethyl)-, (2R)-rel-; Morpholine, 2-[(R)-(2-ethoxyphenoxy)phenylmethyl]-, (2R)-rel-; Reboxetina; DTXSID1048257; reboxetinum; RefChem:930594; N06AX18; DTXCID301471552; Morpholine, 2-((R)-(2-ethoxyphenoxy)phenylmethyl)-, (2R)-; (2S)-2-((S)-2-ethoxyphenoxy(phenyl)methyl)morpholine; Edronax; 98769-81-4; (2R)-2-[(R)-(2-ethoxyphenoxy)-phenylmethyl]morpholine

Frequently Asked Questions

What are the CAS number and molecular formula of Reboxetine?

CAS 71620-89-8; molecular formula C19H23NO3; molecular weight — g/mol.

What other names is Reboxetine known by?

Reboxetine, 71620-89-8, 947S0YZ36I, Morpholine, 2-((R)-(2-ethoxyphenoxy)phenylmethyl)-, (2R)-rel-, Morpholine, 2-[(R)-(2-ethoxyphenoxy)phenylmethyl]-, (2R)-rel-, Reboxetina.

What are the key physical properties of Reboxetine?

Melting Point: 170-171 °C (Mesylate salt); Melting Point: 170-171 °C; LogP: 3.1.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.