雷帕霉素（CAS 53123-88-9）：分子式 C51H79NO13、分子量 914.2。
| CAS号 | 53123-88-9 |
|---|---|
| 分子式 | C51H79NO13 |
| 分子量 | 914.2 |
| 熔点 | 183-185 °C |
| 沸点 | 183-185 |
| LogP | 4.63 |
| 应用领域 | Uses: Triene macrolide antibiotic derived from Streptomyces hygroscopicus、Used in immunochemistry research and as a therapeutic immunosuppressant and antirestenotic (blocks reoccurrence of stenosis)、[Merck Index]、Tool for immunochemistry.、Medication: Immunosuppressant、Used to prevent rejection in organ transplantation、it is especially useful in kidney transplants. [Wikipedia]、Use Classification: Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients、Methods of Manufacturing: Triene macrolide antibiotic isolated from Streptomyces hygroscopicus.、Formulations、Preparations: Rapamune、Rapamycin、Oral: Solution 1mg、mL Rapamune (Wyeth). Tablets: 1 mg Rapamune (with povidone)、(Wyeth)、2 mg Rapamune (with Povidone)、(Wyeth).、General Manufacturing Information: Information available in 2004 indicated that Sirolimus was used in the manufacture of pharmaceutical preparations in the following countries: Argentina、Australia、Austria、Belgium、Brazil、Canada、Chile、Colombia、Czech Republic、Denmark、Finland、France、Germany、Greece、Ireland、Israel、Italy、Mexico、New Zealand、Norway、Poland、Romania、Singapore、Spain、Sweden、Switzerland、Thailand、United Kingdom、USA (1、2) |
登记用途：Uses: Triene macrolide antibiotic derived from Streptomyces hygroscopicus、Used in immunochemistry research and as a therapeutic immunosuppressant and antirestenotic (blocks reoccurrence of stenosis)、[Merck Index]、Tool for immunochemistry.、Medication: Immunosuppressant、Used to prevent rejection in organ transplantation、it is especially useful in kidney transplants. [Wikipedia]、Use Classification: Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients、Methods of Manufacturing: Triene macrolide antibiotic isolated from Streptomyces hygroscopicus.、Formulations、Preparations: Rapamune、Rapamycin、Oral: Solution 1mg、mL Rapamune (Wyeth). Tablets: 1 mg Rapamune (with povidone)、(Wyeth)、2 mg Rapamune (with Povidone)、(Wyeth).、General Manufacturing Information: Information available in 2004 indicated that Sirolimus was used in the manufacture of pharmaceutical preparations in the following countries: Argentina、Australia、Austria、Belgium、Brazil、Canada、Chile、Colombia、Czech Republic、Denmark、Finland、France、Germany、Greece、Ireland、Israel、Italy、Mexico、New Zealand、Norway、Poland、Romania、Singapore、Spain、Sweden、Switzerland、Thailand、United Kingdom、USA (1、2)。
雷帕霉素 是一种化工化合物，登记 CAS 号为 53123-88-9，分子式 C51H79NO13（分子量 914.2）。
登记 CAS 号：53123-88-9
其分子式 C51H79NO13 由 51 个碳、79 个氢、1 个氮、13 个氧 组成。
别名/同义词：雷帕霉素 · Rapamycin · Sirolimus
雷帕霉素 的 CAS 登记号为 53123-88-9。
分子式 C51H79NO13，分子量 914.2。
别名/同义词：雷帕霉素、Rapamycin、Sirolimus。
登记用途：Uses: Triene macrolide antibiotic derived from Streptomyces hygroscopicus、Used in immunochemistry research and as a therapeutic immunosuppressant and antirestenotic (blocks reoccurrence of stenosis)、[Merck Index]、Tool for immunochemistry.、Medication: Immunosuppressant、Used to prevent rejection in organ transplantation、it is especially useful in kidney transplants. [Wikipedia]、Use Classification: Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients、Methods of Manufacturing: Triene macrolide antibiotic isolated from Streptomyces hygroscopicus.、Formulations、Preparations: Rapamune、Rapamycin、Oral: Solution 1mg、mL Rapamune (Wyeth). Tablets: 1 mg Rapamune (with povidone)、(Wyeth)、2 mg Rapamune (with Povidone)、(Wyeth).、General Manufacturing Information: Information available in 2004 indicated that Sirolimus was used in the manufacture of pharmaceutical preparations in the following countries: Argentina、Australia、Austria、Belgium、Brazil、Canada、Chile、Colombia、Czech Republic、Denmark、Finland、France、Germany、Greece、Ireland、Israel、Italy、Mexico、New Zealand、Norway、Poland、Romania、Singapore、Spain、Sweden、Switzerland、Thailand、United Kingdom、USA (1、2)。
雷帕霉素（CAS 53123-88-9）的独立参考数据，整理自公开化学数据库。
| CAS Registry Number | 53123-88-9 |
|---|---|
| PubChem CID | 5284616 |
| Molecular formula | C51H79NO13 |
| IUPAC name | (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone |
| UNII (FDA) | W36ZG6FT64 |
| Molecular Weight | 914.2 |
|---|---|
| XLogP3 | 6 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 13 |
| Rotatable Bond Count | 6 |
| Exact Mass | 913.55514157 |
| Monoisotopic Mass | 913.55514157 |
| Topological Polar Surface Area | 195 |
| Heavy Atom Count | 65 |
| Boiling Point | 183-185 |
|---|---|
| Melting Point | 183-185 °C |
| Solubility | 1.73e-03 g/L |
| LogP | 4.63 |
| LogP | 4.3 |
rapamycin; Sirolimus; (-)-Rapamycin; 53123-88-9; Rapamune; rapalimus; AY-22989; WY-090217; FYARRO; HYFTOR; sirolimusum; Npc-12g; Antibiotic AY 22989; RAPA; Rapammune; SILA 9268A
| GHS notification summary | 4.7% (2 / 43) |
|---|
| GHS notification summary | 4.7% (2 / 43) |
|---|---|
| Reported hazard statements | H341 (11.6%), H351 (79.1%), H361 (81.4%), H372 (81.4%) |
This chemical does not meet GHS hazard criteria for 4.7% (2 of 43) of reports.
H341 (11.6%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]
Sirolimus · CAS 53123-88-9 · C51H79NO13. UNII W36ZG6FT64. Boiling Point: 183-185; Melting Point: 183-185 °C; Solubility: 1.73e-03 g/L.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: Rapamycin