Rapamycin (CAS 53123-88-9) — formula C51H79NO13, molecular weight 914.2.
| CAS Number | 53123-88-9 |
|---|---|
| Molecular Formula | C51H79NO13 |
| Molecular Weight | 914.2 |
| Melting Point | 183-185 °C |
| Boiling Point | 183-185 |
| LogP | 4.63 |
| Applications | Uses: Triene macrolide antibiotic derived from Streptomyces hygroscopicus, Used in immunochemistry research and as a therapeutic immunosuppressant and antirestenotic (blocks reoccurrence of stenosis), [Merck Index], Tool for immunochemistry., Medication: Immunosuppressant, Used to prevent rejection in organ transplantation, it is especially useful in kidney transplants. [Wikipedia], Use Classification: Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients, Methods of Manufacturing: Triene macrolide antibiotic isolated from Streptomyces hygroscopicus., Formulations, Preparations: Rapamune, Rapamycin, Oral: Solution 1mg, mL Rapamune (Wyeth). Tablets: 1 mg Rapamune (with povidone), (Wyeth), 2 mg Rapamune (with Povidone), (Wyeth)., General Manufacturing Information: Information available in 2004 indicated that Sirolimus was used in the manufacture of pharmaceutical preparations in the following countries: Argentina, Australia, Austria, Belgium, Brazil, Canada, Chile, Colombia, Czech Republic, Denmark, Finland, France, Germany, Greece, Ireland, Israel, Italy, Mexico, New Zealand, Norway, Poland, Romania, Singapore, Spain, Sweden, Switzerland, Thailand, United Kingdom, USA (1, 2) |
Documented applications: Uses: Triene macrolide antibiotic derived from Streptomyces hygroscopicus, Used in immunochemistry research and as a therapeutic immunosuppressant and antirestenotic (blocks reoccurrence of stenosis), [Merck Index], Tool for immunochemistry., Medication: Immunosuppressant, Used to prevent rejection in organ transplantation, it is especially useful in kidney transplants. [Wikipedia], Use Classification: Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients, Methods of Manufacturing: Triene macrolide antibiotic isolated from Streptomyces hygroscopicus., Formulations, Preparations: Rapamune, Rapamycin, Oral: Solution 1mg, mL Rapamune (Wyeth). Tablets: 1 mg Rapamune (with povidone), (Wyeth), 2 mg Rapamune (with Povidone), (Wyeth)., General Manufacturing Information: Information available in 2004 indicated that Sirolimus was used in the manufacture of pharmaceutical preparations in the following countries: Argentina, Australia, Austria, Belgium, Brazil, Canada, Chile, Colombia, Czech Republic, Denmark, Finland, France, Germany, Greece, Ireland, Israel, Italy, Mexico, New Zealand, Norway, Poland, Romania, Singapore, Spain, Sweden, Switzerland, Thailand, United Kingdom, USA (1, 2).
Rapamycin is a chemical compound with CAS registry number 53123-88-9 and molecular formula C51H79NO13 (molecular weight 914.2).
CAS number: 53123-88-9
Its molecular formula C51H79NO13 comprises 51 C, 79 H, 1 N, 13 O atoms.
Also known as: Rapamycin · 雷帕霉素 · Sirolimus
The CAS registry number of Rapamycin is 53123-88-9.
Molecular formula C51H79NO13, molecular weight 914.2.
It is also registered under: Rapamycin, 雷帕霉素, Sirolimus.
Recorded applications: Uses: Triene macrolide antibiotic derived from Streptomyces hygroscopicus, Used in immunochemistry research and as a therapeutic immunosuppressant and antirestenotic (blocks reoccurrence of stenosis), [Merck Index], Tool for immunochemistry., Medication: Immunosuppressant, Used to prevent rejection in organ transplantation, it is especially useful in kidney transplants. [Wikipedia], Use Classification: Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients, Methods of Manufacturing: Triene macrolide antibiotic isolated from Streptomyces hygroscopicus., Formulations, Preparations: Rapamune, Rapamycin, Oral: Solution 1mg, mL Rapamune (Wyeth). Tablets: 1 mg Rapamune (with povidone), (Wyeth), 2 mg Rapamune (with Povidone), (Wyeth)., General Manufacturing Information: Information available in 2004 indicated that Sirolimus was used in the manufacture of pharmaceutical preparations in the following countries: Argentina, Australia, Austria, Belgium, Brazil, Canada, Chile, Colombia, Czech Republic, Denmark, Finland, France, Germany, Greece, Ireland, Israel, Italy, Mexico, New Zealand, Norway, Poland, Romania, Singapore, Spain, Sweden, Switzerland, Thailand, United Kingdom, USA (1, 2).
Independent reference data for Rapamycin (CAS 53123-88-9), compiled from public chemistry databases.
| CAS Registry Number | 53123-88-9 |
|---|---|
| PubChem CID | 5284616 |
| Molecular formula | C51H79NO13 |
| IUPAC name | (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone |
| UNII (FDA) | W36ZG6FT64 |
| Molecular Weight | 914.2 |
|---|---|
| XLogP3 | 6 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 13 |
| Rotatable Bond Count | 6 |
| Exact Mass | 913.55514157 |
| Monoisotopic Mass | 913.55514157 |
| Topological Polar Surface Area | 195 |
| Heavy Atom Count | 65 |
| Boiling Point | 183-185 |
|---|---|
| Melting Point | 183-185 °C |
| Solubility | 1.73e-03 g/L |
| LogP | 4.63 |
| LogP | 4.3 |
rapamycin; Sirolimus; (-)-Rapamycin; 53123-88-9; Rapamune; rapalimus; AY-22989; WY-090217; FYARRO; HYFTOR; sirolimusum; Npc-12g; Antibiotic AY 22989; RAPA; Rapammune; SILA 9268A
| GHS notification summary | 4.7% (2 / 43) |
|---|
| GHS notification summary | 4.7% (2 / 43) |
|---|---|
| Reported hazard statements | H341 (11.6%), H351 (79.1%), H361 (81.4%), H372 (81.4%) |
This chemical does not meet GHS hazard criteria for 4.7% (2 of 43) of reports.
H341 (11.6%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]
Sirolimus · CAS 53123-88-9 · C51H79NO13. UNII W36ZG6FT64. Boiling Point: 183-185; Melting Point: 183-185 °C; Solubility: 1.73e-03 g/L.
Source: PubChem / Wikidata; the batch COA governs where values differ.
Supplier: Jinan Shenghe Chemical Co., Ltd.
中文页面: 雷帕霉素