喹那普利

Description

Quinapril · CAS 85441-61-8 · C25H30N2O5. UNII RJ84Y44811. Melting Point: 120-130 °C; Melting Point: 120 - 130 °C; Solubility: 8.50e-03 g/L.

Identification

CAS Registry Number	85441-61-8
PubChem CID	54892
Molecular formula	C25H30N2O5
IUPAC name	(3S)-2-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-3,4-dihydro-1H-isoquinoline-3-carboxylic acid
UNII (FDA)	RJ84Y44811

Computed Descriptors

Molecular Weight	438.5
XLogP3	1.2
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	10
Exact Mass	438.21547206
Monoisotopic Mass	438.21547206
Topological Polar Surface Area	95.9
Heavy Atom Count	32
Formal Charge	0

Physical & Chemical Properties

Melting Point	120-130 °C
Melting Point	120 - 130 °C
Solubility	8.50e-03 g/L
LogP	0.86
LogP	3.2
Dissociation Constants	2.8

Physical description & handling notes

• Solid
• 205.1 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 191.64 Ų [M+H-H2O]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 202.84 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 205.79 Ų [M+K]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 204.4 Ų [M+H]+ [CCS Type: DT; Method: single field calibrated]

Documented Uses

• Use (kg; approx.) in Germany (2009): >500
• Consumption (g per capita; approx.) in Germany (2009): 0.00611
• Consumption (g per capita) in the USA (2002): 0.0167
• For the treatment of hypertension and as adjunct therapy in the treatment of congestive heart failure. May also be used to slow the rate of progression of renal disease in hypertensive individuals with diabetes mellitus and microalbuminuria or overt nephropathy.
• Quinapril is indicated for the treatment of hypertension and as an adjunct therapy in the treatment of heart failure. Quinapril in combination with hydrochlorothiazide is indicated for the treatment of hypertension.
• Quinapril is an angiotensin-converting enzyme (ACE) inhibitor developed in the 1980s. Researchers determined that quinapril had a lower incidence of adverse events than other ACE inhibitors (ACEi) like captopril and enalapril, as well as the thiazide diuretic chlorthalidone. Quinapril has effectively lowered systolic blood pressure by 13 mm Hg and diastolic blood pressure by 10 mm Hg in approximately 2 out of 3 individuals.

Synonyms

quinapril; 85441-61-8; Quinaprilum; C09AA06; RJ84Y44811; CHEBI:8713; DTXSID4023547; RefChem:57154; DTXCID303547; PD 1094522; PD 109452 2; PD 109,452 2; PD-109,452-2; Quinaprilum [Latin]; Accuretic; Quinapril (INN)

Frequently Asked Questions

What are the CAS number and molecular formula of Quinapril?

CAS 85441-61-8; molecular formula C25H30N2O5; molecular weight — g/mol.

What other names is Quinapril known by?

quinapril, 85441-61-8, Quinaprilum, C09AA06, RJ84Y44811, CHEBI:8713.

What are the key physical properties of Quinapril?

Melting Point: 120-130 °C; Melting Point: 120 - 130 °C; Solubility: 8.50e-03 g/L; LogP: 0.86.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.