Pyrimethamine

Description

Pyrimethamine · CAS 58-14-0 · C12H13ClN4. UNII Z3614QOX8W. Melting Point: 233.5; Melting Point: 233.5 °C; Solubility: 121.

Identification

CAS Registry Number	58-14-0
PubChem CID	4993
Molecular formula	C12H13ClN4
IUPAC name	5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine
UNII (FDA)	Z3614QOX8W

Computed Descriptors

Molecular Weight	248.71
XLogP3	2.7
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	2
Exact Mass	248.0828741
Monoisotopic Mass	248.0828741
Topological Polar Surface Area	77.8
Heavy Atom Count	17
Formal Charge	0

Physical & Chemical Properties

Melting Point	233.5
Melting Point	233.5 °C
Solubility	121
Solubility	1.79e-01 g/L
LogP	2.69
LogP	log Kow = 2.69
LogP	2.7
Dissociation Constants	7.34 (at 20 °C)

Physical description & handling notes

• Pyrimethamine is an odorless white crystalline powder. Tasteless. An antimalarial drug.
• Solid
• Crystals
• White scored tablets contains 25 mg pyrimethamine /Daraprim/
• 451 to 453 °F (capillary) (NTP, 1992)
• 233-234 °C (capillary); 240-242 °C (copper block)

GHS Hazard Classification

Reported hazard statements	H302 (99.2%)

Documented Uses

• For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine
• Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
• Pharmaceuticals -> Animal Drugs -> Approved in Taiwan
• Breast Feeding; Lactation; Milk, Human; Anti-infective Agents; Antiparasitic Agents; Antimalarials; Antiprotozoal Agents
• Antipneumocystosis and antitoxoplasmosis medicines
• Pyrimethamine is an antiparasitic prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of Toxoplasma gondiiinfection (toxoplasmosis). Pyrimethamine is usually used together with a sulfonamide (sulfa medicine) to treat toxoplasmosis.

Synonyms

pyrimethamine; 58-14-0; Daraprim; Chloridine; 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine; Chloridin; Diaminopyritamin; Ethylpyrimidine; Pirimecidan; Pirimetamin; Pirimetamina; Chloridyn; Darachlor; Erbaprelina; Khloridin; Tindurin

Frequently Asked Questions

What are the CAS number and molecular formula of Pyrimethamine?

CAS 58-14-0; molecular formula C12H13ClN4; molecular weight — g/mol.

What other names is Pyrimethamine known by?

pyrimethamine, 58-14-0, Daraprim, Chloridine, 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine, Chloridin.

Is Pyrimethamine classified as hazardous?

Hazard statements reported: H302.

What are the key physical properties of Pyrimethamine?

Melting Point: 233.5; Melting Point: 233.5 °C; Solubility: 121; Solubility: 1.79e-01 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.