Pyrazine

Description

Pyrazine is identified by CAS 290-37-9, molecular formula C4H4N2 and molecular weight 80.04 g/mol. UNII 2JKE371789; ChEBI 30953; InChIKey KYQCOXFCLRTKLS-UHFFFAOYSA-N. Boiling Point: 115.00 to 116.00 °C. @ 760.00 mm Hg; Boiling Point: 115-118 °C; Melting Point: 54 - 56 °C.

Identification

CAS Registry Number	290-37-9
PubChem CID	9261
Molecular formula	C4H4N2
Molecular weight	80.04 g/mol
IUPAC name	pyrazine
InChIKey	KYQCOXFCLRTKLS-UHFFFAOYSA-N
UNII (FDA)	2JKE371789
ChEBI ID	CHEBI:30953
FEMA number	4015
JECFA number	951

Computed Descriptors

Molecular Weight	80.09
XLogP3	-0.2
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	0
Exact Mass	80.037448136
Monoisotopic Mass	80.037448136
Topological Polar Surface Area	25.8
Heavy Atom Count	6
Formal Charge	0

Physical & Chemical Properties

Boiling Point	115.00 to 116.00 °C. @ 760.00 mm Hg
Boiling Point	115-118 °C
Melting Point	54 - 56 °C
LogP	-0.26
LogP	-0.05
Ionization Efficiency	0.17
Ionization Efficiency	2.7
Ionization Efficiency	MeCN (80%)
Ionization Efficiency	DOI:10.1038/s41598-020-62573-z

Physical description & handling notes

• Solid with a strong odor like pyridine; [Merck Index] White crystalline solid with a strong odor; [Alfa Aesar MSDS]
• Solid
• deliquescent crystals or wax-like solid with a pungent, sweet, corn-like, nutty odour
• freely soluble in water, organic solvents
• very soluble (in ethanol)
• Positive

Regulatory Status

Regulatory & Food Contact	EU Flavoring substances FDA Substance added to food: FLAVORING AGENT OR ADJUVANT Flavoring Agents FLAVOURING_AGENT: Flavouring Agent No safety concern at current levels of intake when used as a flavouring agent TRS 909-JECFA 57/51

GHS Hazard Classification

Reported hazard statements	H225 (47.9%), H228 (44.2%), H315 (99.4%), H319 (99.4%), H335 (98.8%)

Documented Uses

• Used as a flavoring agent; [FDA]
• Flavouring Agent -> FLAVOURING_AGENT -> JECFA Functional Classes
• Flavoring Agents -> JECFA Flavorings Index

Synonyms

PYRAZINE; 290-37-9; 1,4-Diazine; p-Diazine; Paradiazine; Piazine; 1,4-Diazabenzene; pyrazin; 1,4-Diazin; DTXSID8049410; NSC-400221; FEMA NO. 4015; 2JKE371789; CHEMBL15797; CHEBI:30953; RefChem:1113271

Frequently Asked Questions

What are the CAS number and molecular formula of Pyrazine?

CAS 290-37-9; molecular formula C4H4N2; molecular weight 80.04 g/mol.

What other names is Pyrazine known by?

PYRAZINE, 290-37-9, 1,4-Diazine, p-Diazine, Paradiazine, Piazine.

What is the regulatory status of Pyrazine?

Documented regulatory listings: EU Flavoring substances; FDA Substance added to food: FLAVORING AGENT OR ADJUVANT; Flavoring Agents.

Is Pyrazine classified as hazardous?

Hazard statements reported: H225, H228, H315, H319, H335.

What are the key physical properties of Pyrazine?

Boiling Point: 115.00 to 116.00 °C. @ 760.00 mm Hg; Boiling Point: 115-118 °C; Melting Point: 54 - 56 °C; LogP: -0.26.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.