protriptyline

Description

protriptyline · CAS 438-60-8 · C19H21N. UNII 4NDU154T12. Solubility: 1.04; Solubility: 2.31e-04 g/L; LogP: 4.7.

Identification

Computed Descriptors

Physical & Chemical Properties

Physical description & handling notes

• Solid
• 169-171 °C (Protriptyline HCl)
• Max absorption 290 nm (e= 13,311); MP: 169-171 °C; crystals from isopropanol- ethyl ether /hydrochloride/
• 169 - 171 °C (protriptyline hydrochloride)
• SOL: 1 G IN ABOUT 2 ML WATER, ABOUT 2 ML METHANOL, ABOUT 2.3 ML CHLOROFORM, ABOUT 4 ML ALCOHOL; PRACTICALLY INSOL IN ETHER /HYDROCHLORIDE/
• Freely sol in water /hydrochloride/

Documented Uses

• For the treatment of depression.
• Engelhardt, Christy, Belgian patent 617,967 (1962 to Merck & Co) CA 59, 517f (1963); Tishler et al, US patent 3,244,748 & 3,271,451 (both 1966 to Merck & Co); Engelhardt et al, J Med Chem 11, 325 (1968).
• Protriptyline hydrochloride is a tricyclic antidepressant used to improve mood in people with depression. It is also used for anxiety. Protriptyline was first patented in 1962, and it is sold under many brand names. It is an amine with the empirical formula of CHN. It is a more potent antidepressant and has fewer sedative and tranquilizing effects than other TCAs.
• Protriptyline is a tricyclic antidepressant that was previously widely used in the therapy of major depression. Most of the tricyclic antidepressants have been shown to cause a low rate of mild and transient serum enzyme elevations and rare cases of clinically apparent acute cholestatic liver injury. The potential hepatotoxicity specifically of protriptyline, however, has not been well defined.
• Breast Feeding; Lactation; Milk, Human; Antidepressive Agents; Antidepressive Agents, Tricyclic
• Protriptyline (Class: Stimulants, Added Date: 10-1998)

Synonyms

protriptyline; Protryptyline; Amimetilina; 438-60-8; Triptil; Protriptilina; Protriptylinum; 7-(3-Methylaminopropyl)-1,2:5,6-dibenzocycloheptatriene; N-Methyl-5H-dibenzo[a,d]cycloheptene-5-propanamine; N-Methyl-5H-dibenzo[a,d]cycloheptene-5-propylamine; 5-(3-Methylaminopropyl)-5H-Dibenzo[a,d]cycloheptene; N-3-(5H-Dibenzo(a,d)cyclohepten-5-yl)propyl-N-methylamine; 3-(5H-dibenzo[a,d][7]annulen-5-yl)-N-methylpropan-1-amine; N-Methyl-5H-dibenzo(a,d)cycloheptene-5-propylamine; 5-(3-Methylaminopropyl)-5H-dibenzo(a,d)cycloheptene; 4NDU154T12

Frequently Asked Questions

What are the CAS number and molecular formula of protriptyline?

CAS 438-60-8; molecular formula C19H21N; molecular weight — g/mol.

What other names is protriptyline known by?

protriptyline, Protryptyline, Amimetilina, 438-60-8, Triptil, Protriptilina.

What are the key physical properties of protriptyline?

Solubility: 1.04; Solubility: 2.31e-04 g/L; LogP: 4.7; LogP: log Kow= 1.18 @ 25 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.