probucol

Description

probucol · CAS 23288-49-5 · C31H48O2S2. UNII P3CTH044XJ. Melting Point: 125; Melting Point: 125 °C; Solubility: 4.18e-05 g/L.

Identification

CAS Registry Number	23288-49-5
PubChem CID	4912
Molecular formula	C31H48O2S2
IUPAC name	2,6-ditert-butyl-4-[2-(3,5-ditert-butyl-4-hydroxyphenyl)sulfanylpropan-2-ylsulfanyl]phenol
UNII (FDA)	P3CTH044XJ

Computed Descriptors

Molecular Weight	516.8
XLogP3	11.3
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	8
Exact Mass	516.30957312
Monoisotopic Mass	516.30957312
Topological Polar Surface Area	91.1
Heavy Atom Count	35
Formal Charge	0

Physical & Chemical Properties

Melting Point	125
Melting Point	125 °C
Solubility	4.18e-05 g/L

Physical description & handling notes

• Solid
• 216.78 Ų [M+K]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 213.55 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 216.41 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 211.81 Ų [M+H-H2O]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• Probucol lowers cholesterol levels by increasing LDL (low-density lipoprotein) breakdown. Additionally, probucol may inhibit cholesterol synthesis and delay cholesterol absorption. Probucol is a powerful antioxidant drug normally used to prevent vascular disease caused by the free radicals in the body.

GHS Hazard Classification

Reported hazard statements	H315 (100%), H319 (100%), H335 (100%)

Documented Uses

• Used to lower LDL and HDL cholesterol.
• Take with food. Food increases bioavailability.
• Substances used to lower plasma CHOLESTEROL levels.
• Naturally occurring or synthetic substances that inhibit or retard oxidation reactions. They counteract the damaging effects of oxidation in animal tissues.
• C10A - Lipid modifying agents, plain
• C10AX - Other lipid modifying agents

Synonyms

probucol; 23288-49-5; Lorelco; Biphenabid; Bisphenabid; Bisbid; Lurselle; DH-581; Sinlestal; Probucolum; DH 581; Acetone bis(3,5-di-tert-butyl-4-hydroxyphenyl) mercaptole; 4,4'-(Isopropylidenedithio)bis(2,6-di-tert-butylphenol); DTXSID2045440; 2,6-ditert-butyl-4-[2-(3,5-ditert-butyl-4-hydroxyphenyl)sulfanylpropan-2-ylsulfanyl]phenol; DH581

Frequently Asked Questions

What are the CAS number and molecular formula of probucol?

CAS 23288-49-5; molecular formula C31H48O2S2; molecular weight — g/mol.

What other names is probucol known by?

probucol, 23288-49-5, Lorelco, Biphenabid, Bisphenabid, Bisbid.

Is probucol classified as hazardous?

Hazard statements reported: H315, H319, H335.

What are the key physical properties of probucol?

Melting Point: 125; Melting Point: 125 °C; Solubility: 4.18e-05 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.