Plicamycin

Description

Plicamycin · CAS 18378-89-7 · C52H76O24. UNII NIJ123W41V. Melting Point: 181.5; Melting Point: 180-183 °C.

Identification

CAS Registry Number	18378-89-7
PubChem CID	163659
Molecular formula	C52H76O24
UNII (FDA)	NIJ123W41V

Computed Descriptors

Molecular Weight	1085.1
XLogP3	0.6
Hydrogen Bond Donor Count	11
Hydrogen Bond Acceptor Count	24
Rotatable Bond Count	15
Exact Mass	1084.47265329
Monoisotopic Mass	1084.47265329
Topological Polar Surface Area	358
Heavy Atom Count	76
Formal Charge	0

Physical & Chemical Properties

Melting Point	181.5
Melting Point	180-183 °C

Physical description & handling notes

• Solid
• YELLOW, CRYSTALLINE POWDER SHOWING BIREFRINGENCE
• ODORLESS
• Sol in lower alcohols, acetone, ethyl acetate, water. Moderately sol in chloroform. Slightly sol in ether, benzene.
• 1 G SOL IN LESS THAN 200 ML WATER, 2000 ML ALCOHOL, IN LESS THAN 1000 ML METHANOL, IN MORE THAN 10 ML ETHYL ACETATE
• Log Kow = -0.25 at pH 7.4

GHS Hazard Classification

Reported hazard statements	H302 (95.6%)

Documented Uses

• Mesh Heading: Antibiotics, antineoplastic, fluorescent dyes, nucleic acid synthesis inhibitors, protein synthesis inhibitors
• Oligosaccharide antibiotic produced by Streptomyces argillaceus n. Sp. And S. Tanashiensis. Hungarian patent 155,679 (1969 to Gyogyszerkutato Intezet).
• ELABORATED DURING CULTURE OF SUITABLE STRAIN OF STREPTOMYCES, RECOVERED BY EXTRACTION WITH 1-BUTANOL, & PURIFIED BY CHROMATOGRAPHY. ELUATE CONTAINS MAGNESIUM SALT OF MITHRAMYCIN WHICH YIELDS ANTIBIOTIC ON ACIDIFICATION & ETHYL ACETATE EXTRACTION.
• For the treatment of testicular cancer, as well as hypercalcemia and hypercalciuria associated with a variety of advanced forms of cancer.
• Plicamycin, which was formerly known as mithramycin, is an antibiotic that is used as an anticancer agent in the therapy of testicular and germ cell cancers. Plicamycin causes acute hepatic injury that arises within days of starting therapy, but is usually transient and asymptomatic and rarely leads to jaundice. Plicamycin has not been approved for use as cancer chemotherapy in the United States, but continues to be used on an investigational basis.
• Plicamycin is of limited value in the treatment of neoplastic disease because of its severe toxicity.

Synonyms

plicamycin; MITHRAMYCIN; Mithracin; 18378-89-7; Aureolic acid; Mithramycinum; Mithramycine; Plicamycinum; Plicamycine; Aurelic acid; Mitramycin; Plicamicina; antibiotic LA-7017; NSC 24559; NIJ123W41V; Antibiotic LA 7017

Frequently Asked Questions

What are the CAS number and molecular formula of Plicamycin?

CAS 18378-89-7; molecular formula C52H76O24; molecular weight — g/mol.

What other names is Plicamycin known by?

plicamycin, MITHRAMYCIN, Mithracin, 18378-89-7, Aureolic acid, Mithramycinum.

Is Plicamycin classified as hazardous?

Hazard statements reported: H302.

What are the key physical properties of Plicamycin?

Melting Point: 181.5; Melting Point: 180-183 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.