Pirlindole

Description

Pirlindole · CAS 60762-57-4 · C15H18N2. UNII V39YPH45FZ. Boiling Point: 369; Melting Point: 145; Solubility: 0.0168.

Identification

CAS Registry Number	60762-57-4
PubChem CID	68802
Molecular formula	C15H18N2
IUPAC name	12-methyl-1,4-diazatetracyclo[7.6.1.05,16.010,15]hexadeca-9(16),10(15),11,13-tetraene
UNII (FDA)	V39YPH45FZ

Computed Descriptors

Molecular Weight	226.32
XLogP3	2.3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	0
Exact Mass	226.146998583
Monoisotopic Mass	226.146998583
Topological Polar Surface Area	17
Heavy Atom Count	17
Formal Charge	0

Physical & Chemical Properties

Boiling Point	369
Melting Point	145
Solubility	0.0168
LogP	2.8

Physical description & handling notes

• Pirlindole regulates that metabolism of norepinephrine and catecholamines, leading to relief of depressive symptoms. The prevention of breakdown of these neuromodulators is thought to elevate mood.

GHS Hazard Classification

Reported hazard statements	H319 (100%), H413 (100%)

Documented Uses

• Substances that inhibit or prevent the proliferation of NEOPLASMS.
• A chemically heterogeneous group of drugs that have in common the ability to block oxidative deamination of naturally occurring monoamines. (From Gilman, et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p414)
• Well absorbed with a bioavailability of 90%.
• Mainly renal, with 0.4-0.5% being excreted in the urine as unchanged drug in healthy males. Renal excretion was the main route of elimination of the metabolites in man.
• High plasma clearance (450–1000 1/h) in one study.
• The drug is metabolized significantly through the hepatic system. From studies in dogs and rats, pirlindole has a bioavailability of between 20 and 30% due to the hepatic first-pass effect on this medication. The rat eliminates mainly unconjugated drug while the dog eliminates mostly conjugated drug.

Synonyms

Pirlindole; 60762-57-4; pirlindol; Pyrazidol; 8-Methyl-2,3,3a,4,5,6-hexahydro-1H-pyrazino[3,2,1-jk]carbazole; Pirlindolum; V39YPH45FZ; DTXSID8048230; pyrlindole; 1H-Pyrazino(3,2,1-jk)carbazole, 2,3,3a,4,5,6-hexahydro-8-methyl-, monohydrochloride; 8-Methyl-2,3,3a,4,5,6-hexahydro-1H-pyrazino(3,2,1-jk)carbazole; RefChem:174549; DTXCID9028205; 1,10-trimethylene-8-methyl-1,2,3,4-tetrahydropyrazino(1,2-a)indole; 12-methyl-1,4-diazatetracyclo(7.6.1.0?,1?.01?,1?)hexadeca-9(16),10,12,14-tetraene; Pirlindole free base

Frequently Asked Questions

What are the CAS number and molecular formula of Pirlindole?

CAS 60762-57-4; molecular formula C15H18N2; molecular weight — g/mol.

What other names is Pirlindole known by?

Pirlindole, 60762-57-4, pirlindol, Pyrazidol, 8-Methyl-2,3,3a,4,5,6-hexahydro-1H-pyrazino[3,2,1-jk]carbazole, Pirlindolum.

Is Pirlindole classified as hazardous?

Hazard statements reported: H319, H413.

What are the key physical properties of Pirlindole?

Boiling Point: 369; Melting Point: 145; Solubility: 0.0168; LogP: 2.8.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.