phensuximide

Description

phensuximide · CAS 86-34-0 · C11H11NO2. UNII 6WVL9C355G. Melting Point: 72; Melting Point: 72 °C; Solubility: 7020.

Identification

CAS Registry Number	86-34-0
PubChem CID	6839
Molecular formula	C11H11NO2
IUPAC name	1-methyl-3-phenylpyrrolidine-2,5-dione
UNII (FDA)	6WVL9C355G

Computed Descriptors

Molecular Weight	189.21
XLogP3	0.8
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	1
Exact Mass	189.078978594
Monoisotopic Mass	189.078978594
Topological Polar Surface Area	37.4
Heavy Atom Count	14
Formal Charge	0

Physical & Chemical Properties

Melting Point	72
Melting Point	72 °C
Solubility	7020
Solubility	2.21e+00 g/L
LogP	0.7
LogP	0.68

Physical description & handling notes

• Solid
• Phensuximide suppresses the paroxysmal three cycle per second spike and wave EEG pattern associated with lapses of consciousness in absence (petit mal) seizures. The frequency of attacks is reduced by depression of nerve transmission in the motor cortex.

GHS Hazard Classification

Reported hazard statements	H302 (100%)

Documented Uses

• Phensuximide (Class: Other Substances, Added Date: 10-1998)
• N03AD - Succinimide derivatives
• QN03AD - Succinimide derivatives
• Phensuximide's mechanism of action not understood, but may act in inhibitory neuronal systems that are important in the generation of the three per second rhythm. It's effects may be related to its ability to inhibit depolarization-induced accumulation of cyclic AMP and cyclic GMP in brain tissue.

Synonyms

Phensuximide; 86-34-0; Succitimal; Lifene; Milontin; Epimid; 1-methyl-3-phenylpyrrolidine-2,5-dione; Phensuximid; Milonton; Mirontin; 1-Methyl-3-phenyl-2,5-pyrrolidinedione; Fensuccimide; Phensuximidum; Fensuximida; Succinimide, N-methyl-2-phenyl-; 1-Methyl-3-Phenylsuccinimide

Frequently Asked Questions

What are the CAS number and molecular formula of phensuximide?

CAS 86-34-0; molecular formula C11H11NO2; molecular weight — g/mol.

What other names is phensuximide known by?

Phensuximide, 86-34-0, Succitimal, Lifene, Milontin, Epimid.

Is phensuximide classified as hazardous?

Hazard statements reported: H302.

What are the key physical properties of phensuximide?

Melting Point: 72; Melting Point: 72 °C; Solubility: 7020; Solubility: 2.21e+00 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.