Papaverine Hydrochloride (CAS 61-25-6) — formula C20H21NO4, molecular weight 339.4; category organic chemicals.
| CAS Number | 61-25-6 |
|---|---|
| Molecular Formula | C20H21NO4 |
| Molecular Weight | 339.4 |
| Melting Point | 226 |
| Boiling Point | Sublimes at 135 °C |
| LogP | log Kow = 2.95 |
| Applications | Uses: A vasodilator used for treatment of hypertension (also as the hydrochloride which is soluble in water)., MEDICATION (VET), MEDICATION, Use Classification: Pharmaceuticals -> Animal Drugs -> Approved in Taiwan, Methods of Manufacturing: From opium or by synthesis., Papaverine was synthesized via the Bischler-Napieralski reaction as follows: the Schotten-Baumann reaction between the phenethylamine and the acyl chloride gave the amide. Cyclization with phosphorous pentoxide afforded the 3, 4-dihydroisoquinoline. Mild dehydrogenation of, 3, 4-dihydroisoquinoline, gave papaverine., Formulations, Preparations: Artegodan, Cepaverin, Cerebid, Cerespan, Dynovas, Optenyl, Pameion, Panergon, Papital T.R., Pavabid, Pavacen, Pavadel, Pavagen, Pavakey, Pavased, Spasmo-Nit, Therapav, Vasal, Vasospan, Papverine hydrochloride, Table: Papaverine Hydrochloride Preparations [Table#4478] |
| Category | Organic Chemicals |
Documented applications: Uses: A vasodilator used for treatment of hypertension (also as the hydrochloride which is soluble in water)., MEDICATION (VET), MEDICATION, Use Classification: Pharmaceuticals -> Animal Drugs -> Approved in Taiwan, Methods of Manufacturing: From opium or by synthesis., Papaverine was synthesized via the Bischler-Napieralski reaction as follows: the Schotten-Baumann reaction between the phenethylamine and the acyl chloride gave the amide. Cyclization with phosphorous pentoxide afforded the 3, 4-dihydroisoquinoline. Mild dehydrogenation of, 3, 4-dihydroisoquinoline, gave papaverine., Formulations, Preparations: Artegodan, Cepaverin, Cerebid, Cerespan, Dynovas, Optenyl, Pameion, Panergon, Papital T.R., Pavabid, Pavacen, Pavadel, Pavagen, Pavakey, Pavased, Spasmo-Nit, Therapav, Vasal, Vasospan, Papverine hydrochloride, Table: Papaverine Hydrochloride Preparations [Table#4478].
Papaverine Hydrochloride is a carbon-based organic compound with CAS registry number 61-25-6 and molecular formula C20H21NO4 (molecular weight 339.4), belonging to the organic chemicals segment of chemical raw materials.
CAS number: 61-25-6
Its molecular formula C20H21NO4 comprises 20 C, 21 H, 1 N, 4 O atoms.
Also known as: Papaverine Hydrochloride · 盐酸罂粟碱
Category: organic chemicals
The CAS registry number of Papaverine Hydrochloride is 61-25-6.
Molecular formula C20H21NO4, molecular weight 339.4.
It is also registered under: Papaverine Hydrochloride, 盐酸罂粟碱.
Recorded applications: Uses: A vasodilator used for treatment of hypertension (also as the hydrochloride which is soluble in water)., MEDICATION (VET), MEDICATION, Use Classification: Pharmaceuticals -> Animal Drugs -> Approved in Taiwan, Methods of Manufacturing: From opium or by synthesis., Papaverine was synthesized via the Bischler-Napieralski reaction as follows: the Schotten-Baumann reaction between the phenethylamine and the acyl chloride gave the amide. Cyclization with phosphorous pentoxide afforded the 3, 4-dihydroisoquinoline. Mild dehydrogenation of, 3, 4-dihydroisoquinoline, gave papaverine., Formulations, Preparations: Artegodan, Cepaverin, Cerebid, Cerespan, Dynovas, Optenyl, Pameion, Panergon, Papital T.R., Pavabid, Pavacen, Pavadel, Pavagen, Pavakey, Pavased, Spasmo-Nit, Therapav, Vasal, Vasospan, Papverine hydrochloride, Table: Papaverine Hydrochloride Preparations [Table#4478].
Category: Organic Chemicals.
Independent reference data for Papaverine Hydrochloride (CAS 61-25-6), compiled from public chemistry databases.
| CAS Registry Number | 61-25-6 |
|---|---|
| PubChem CID | 4680 |
| Molecular formula | C20H21NO4 |
| IUPAC name | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxyisoquinoline |
| UNII (FDA) | DAA13NKG2Q |
| Molecular Weight | 339.4 |
|---|---|
| XLogP3 | 3.9 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 6 |
| Exact Mass | 339.14705815 |
| Monoisotopic Mass | 339.14705815 |
| Topological Polar Surface Area | 49.8 |
| Heavy Atom Count | 25 |
| Boiling Point | Sublimes at 135 °C |
|---|---|
| Melting Point | 226 |
| Melting Point | 147.5 °C |
| Solubility | In water, 3.733X10-5 mg/L at 37.5 °C |
| Solubility | In water, 35 mg/L at 17 °C |
| Solubility | 1.29e-02 g/L |
| Density | 1.337 g/cu cm at 20 °C |
| LogP | log Kow = 2.95 |
| LogP | 2.95 |
| Dissociation Constants | pKa = 8.07 at 25 °C |
papaverine; 58-74-2; Robaxapap; 1-(3,4-Dimethoxybenzyl)-6,7-dimethoxyisoquinoline; 6,7-Dimethoxy-1-veratrylisoquinoline; 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxyisoquinoline; Pavacap; Papaverinum; DAA13NKG2Q; 1-((3,4-Dimethoxyphenyl)methyl)-6,7-dimethoxyisoquinoline; NSC-136630; Isoquinoline, 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-; Isoquinoline, 1-((3,4-dimethoxyphenyl)methyl)-6,7-dimethoxy-; DTXSID4023418; Pavatym; CHEBI:28241
| Reported hazard statements | H302 |
|---|
H302: Harmful if swallowed [Warning Acute toxicity, oral]
P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)
Papaverine Hydrochloride · CAS 61-25-6 · C20H21NO4. UNII DAA13NKG2Q. Boiling Point: Sublimes at 135 °C; Melting Point: 226; Melting Point: 147.5 °C.
Source: PubChem / Wikidata; the batch COA governs where values differ.
Supplier: Jinan Shenghe Chemical Co., Ltd.
中文页面: 盐酸罂粟碱