帕洛瓦罗汀

Description

Palovarotene · CAS 410528-02-8 · C27H30N2O2. UNII 28K6I5M16G. Solubility: 0.04.

Identification

CAS Registry Number	410528-02-8
PubChem CID	10295295
Molecular formula	C27H30N2O2
IUPAC name	4-[(E)-2-[5,5,8,8-tetramethyl-3-(pyrazol-1-ylmethyl)-6,7-dihydronaphthalen-2-yl]ethenyl]benzoic acid
UNII (FDA)	28K6I5M16G

Computed Descriptors

Molecular Weight	414.5
XLogP3	6.8
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	5
Exact Mass	414.230728204
Monoisotopic Mass	414.230728204
Topological Polar Surface Area	55.1
Heavy Atom Count	31
Formal Charge	0

Physical & Chemical Properties

Solubility	0.04

Documented Uses

• Palovarotene is indicated in Canada to reduce the formation of heterotopic ossification in adults and children (≥8 years old for females and ≥10 years old for males) with Fibrodysplasia Ossificans Progressiva (FOP) by Health Canada and FDA.
• Avoid grapefruit products. Grapefruit-containing products may inhibit the CYP3A4 activity responsible for palovarotene metabolism.
• Avoid St. John's Wort. The significant induction of CYP3A4 metabolism caused by St. John's wort may decrease the effectiveness of palovarotene.
• Take with food. Co-administration with food increases the oral absorption of palovarotene.
• Established Pharmacologic Class [EPC] - Retinoid
• Chemical Structure [CS] - Retinoids

Synonyms

Palovarotene; 410528-02-8; Sohonos; RG-667; RO-3300074; CLM-001; IPN60120; palovaroteno; R-667; IPN-60120; RO3300074; 28K6I5M16G; 4-[(E)-2-[5,5,8,8-tetramethyl-3-(pyrazol-1-ylmethyl)-6,7-dihydronaphthalen-2-yl]ethenyl]benzoic acid; DTXSID301025696; palovarotenum; 4-((E)-2-(5,5,8,8-tetramethyl-3-(pyrazol-1-ylmethyl)-6,7-dihydronaphthalen-2-yl)ethenyl)benzoic acid

Frequently Asked Questions

What are the CAS number and molecular formula of Palovarotene?

CAS 410528-02-8; molecular formula C27H30N2O2; molecular weight — g/mol.

What other names is Palovarotene known by?

Palovarotene, 410528-02-8, Sohonos, RG-667, RO-3300074, CLM-001.

What are the key physical properties of Palovarotene?

Solubility: 0.04.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.