Nitrendipine

Description

Nitrendipine · CAS 39562-70-4 · C18H20N2O6. UNII 9B627AW319. Melting Point: 156-160 °C; Melting Point: 156 - 160 °C; Solubility: 1.42e-02 g/L.

Identification

CAS Registry Number	39562-70-4
PubChem CID	4507
Molecular formula	C18H20N2O6
IUPAC name	5-O-ethyl 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
UNII (FDA)	9B627AW319

Computed Descriptors

Molecular Weight	360.4
XLogP3	2.9
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	6
Exact Mass	360.13213636
Monoisotopic Mass	360.13213636
Topological Polar Surface Area	110
Heavy Atom Count	26
Formal Charge	0

Physical & Chemical Properties

Melting Point	156-160 °C
Melting Point	156 - 160 °C
Solubility	1.42e-02 g/L
LogP	2.88
LogP	2.4

Physical description & handling notes

• Solid
• Insoluble
• 181.9 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 182.2 Ų [M+H]+ [CCS Type: TW; Method: Major Mix IMS/Tof Calibration Kit (Waters)]
• 191.32 Ų [M+K]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 180.38 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

Regulatory Status

GHS notification summary	1.1% (1 / 95)

GHS Hazard Classification

GHS notification summary	1.1% (1 / 95)
Reported hazard statements	H302, H312 (29.5%), H332 (44.2%), H361 (25.3%)

Documented Uses

• Use (kg; approx.) in Germany (2009): >2500
• Consumption (g per capita; approx.) in Germany (2009): 0.0305
• For the treatment of mild to moderate hypertension
• Breast Feeding; Lactation; Antihypertensive Agents; Calcium Channel Blockers; Vasodilator Agents
• Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
• A class of drugs that act by selective inhibition of calcium influx through cellular membranes.

Synonyms

nitrendipine; 39562-70-4; Bayotensin; Baypress; Nidrel; Deiten; 3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; Nitrendipinum; Bay-e-5009; Nitrendipino; Nitrepin; BAY e 5009; 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ethyl methyl ester; DTXSID0023373; 9B627AW319; NSC-758466

Frequently Asked Questions

What are the CAS number and molecular formula of Nitrendipine?

CAS 39562-70-4; molecular formula C18H20N2O6; molecular weight — g/mol.

What other names is Nitrendipine known by?

nitrendipine, 39562-70-4, Bayotensin, Baypress, Nidrel, Deiten.

Is Nitrendipine classified as hazardous?

1.1% of GHS notifications report no hazard classification (1 of 95).

What are the key physical properties of Nitrendipine?

Melting Point: 156-160 °C; Melting Point: 156 - 160 °C; Solubility: 1.42e-02 g/L; LogP: 2.88.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.