N-3,4-dimethylisoxazol-5-yl-N-sulfanilylacetamide

Independent reference data for N-3,4-dimethylisoxazol-5-yl-N-sulfanilylacetamide (CAS 80-74-0), compiled from public chemistry databases.

Registry identifiers across databases

Computed descriptors

Physicochemical values on record

Documented uses on record

Readily absorbed from the gastrointestinal tract. In a pharmacokinetic study, the adjustments for variable renal clearances between oral and intravenous administration and using the unbound plasma concentrations, the bioavailability for an oral dose of sulfisoxazole was found to be 0.95 +/- 0.04.The mean urinary excretion recovery following oral administration of sulfisoxazole is 97% within 48 hours, of which 52% is the parent drug, and the remaining as the N4-acetylated metabolite. It is excreted in human milk. Sulfisoxazole and its acetylated metabolites are excreted primarily by the kidneys through glomerular filtration.

Synonyms and trade names

Sulfisoxazole acetyl; 80-74-0; ACETYL SULFISOXAZOLE; Lipo Gantrisin; acetylsulfafurazole; Acetylsulfisoxazole; GANTRISIN PEDIATRIC; Acetyl sulfafurazole; Sulfafurazole acetyl; Sulfisoxizole acetyl; WBT5QH3KED; NSC-759138; Sulfisoxazole acetyl (USP); Sulfisoxazole acetyl [USP]; N-3,4-Dimethylisoxazol-5-yl-N-sulphanilylacetamide; Acetamide, N-((4-aminophenyl)sulfonyl)-N-(3,4-dimethyl-5-isoxazolyl)-

What the public record says

N-3,4-dimethylisoxazol-5-yl-N-sulfanilylacetamide · CAS 80-74-0 · C13H15N3O4S. UNII WBT5QH3KED. Melting Point: 192.

Physical description and handling notes

Source: PubChem / Wikidata; the batch COA governs where values differ.