methylsulfinylmethane (CAS 67-68-5) — formula C2H6OS, molecular weight 78.01 g/mol; category organic chemicals.
| CAS Number | 67-68-5 |
|---|---|
| Molecular Formula | C2H6OS |
| Molecular Weight | 78.01 g/mol |
| Melting Point | 65.3 °F (NTP, 1992) |
| Boiling Point | 372 °F at 760 mmHg (NTP, 1992) |
| LogP | -0.6 |
| Applications | Uses: Used as a pharmaceutical, a solvent for polymerization and chemical extractions, a paint remover, a preservative for organ transplantation, Occurs naturally in ground water and in grains, vegetables, and many other foods, [CHEMINFO] Used as a solvent for many organic compounds, Also used in industrial cleaners, [HSDB], Semiconductor Manufacturing [Category: Industry], DMSO is not a nutritional supplement. It is used as a treatment for interstitial cystitis, and treatment must be performed by a qualified physician. DMSO is metabolized to methylsulfonylmethane, which is available as a nutritional supplement., Vitrification has become common for cryopreservation of embryos. ...Extended exposure of embryos with both vitrification protocols showed that the DMSO-containing vitrification solutions did not lead to cell membrane damage and death as quickly as the DMSO-free vitrification solutions. To assess embryo viability, the authors recommend that vitrification of early embryos should be combined with extended culture and assessment of normal blastocyst development before transferring to patients., Dimethyl sulfoxide (DMSO) is a molecule with a long history in pharmaceutics and is now well established as a penetration enhancer in topical pharmaceutical formulations. It is currently used for this purpose in diclofenac sodium topical solution (approved in the United States to treat signs and symptoms of osteoarthritis) and idoxuridine topical solution (approved in Europe for the treatment of herpes zoster). ... The clinical use of pharmaceutical-grade DMSO as a penetration enhancer is supported by the robust data that have accumulated over the past 3 decades demonstrating the favorable safety and tolerability profile. Dimethyl sulfoxide is a safe and effective mechanism for facilitating the transdermal delivery of both hydrophilic and lipophilic medications to provide localized drug delivery., For dimethyl sulfoxide (USEPA, OPP Pesticide Code: 000177) there are 0 labels match., SRP: Not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses., For more Uses (Complete) data for DIMETHYL SULFOXIDE (13 total), please visit the HSDB record page., Use (kg, approx.) in Germany (2009): >10000, Consumption (g per capita, approx.) in Germany (2009): 0.122, Excretion rate: 0.68, Calculated removal (%): 75.1, DMSO is an important polar aprotic solvent. In cryobiology DMSO has been used as a cryoprotectant and is still an important constituent of cryoprotectant vitrification mixtures used to preserve organs, tissues, and cell suspensions.[Wikipedia], Use Classification: Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients, Fragrance Ingredients, Flavouring Agent -> FLAVOURING_AGENT -> JECFA Functional Classes, Flavoring Agents -> JECFA Flavorings Index, SOLVENTS, Industry Uses: Laboratory chemicals, Etching agent, Not Known or Reasonably Ascertainable, Cleaning agent, Plating agent, Solvent, Consumer Uses: Solvent, Soil amendments (fertilizers), Household Products: Information on 1 consumer products that contain Dimethyl sulfoxide in the following categories is provided:, • Home Maintenance, Methods of Manufacturing: In industry, DMSO is produced by catalytic oxidation of dimethyl sulfide with oxygen or by oxidation with nitrogen dioxide. The oxidation of dimethyl sulfide with oxygen at 7.2 MPa and 105 °C gives good yields of DMSO., Obtained as a by-product of paper manufacture ... ., Oxidation of dimethyl sulfide with nitrogen tetroxide under anhydrous conditions, sulfide waste liquors., Formulations, Preparations: Rimso-50 (Research Industries) Solution: 50% aqueous solution., Dimethyl Sulfoxide (Bioniche), Solution: 50% aqueous solution, U.S. Production: 2023: 2, 500, 000 - <4, 000, 000 lb, 2022: 2, 2021: 2, 2020: 2, (1972) Probably greater than 4.54x10+5 g, (1975) probably greater than 4.54x10+5 g, Methane, sulfinylbis- is listed as a High Production Volume (HPV) chemical (65FR81686). Chemicals listed as HPV were produced in or imported into the U.S. in >1 million pounds in 1990 and, or 1994. The HPV list is based on the 1990 Inventory Update Rule. (IUR) (40 CFR part 710 subpart B, 51FR21438)., Production volumes for non-confidential chemicals reported under the Inventory Update Rule.[Table#221], For more U.S. Production (Complete) data for DIMETHYL SULFOXIDE (6 total), Computer and Electronic Product Manufacturing, Plastics Product Manufacturing, Transportation Equipment Manufacturing, Electrical Equipment, Appliance, and Component Manufacturing, Pharmaceutical and Medicine Manufacturing, All Other Basic Organic Chemical Manufacturing, Services, Machinery Manufacturing, Adhesive Manufacturing, Paint and Coating Manufacturing, Fabricated Metal Product Manufacturing, 1, 1'-sulfinylbis-: ACTIVE, FDA does not permit its use in horses or dogs intended for breeding purposes, nor in horses slaughtered for food., Dimethyl sulfoxide is used in many paint removers and has many green characteristics. It has low toxicity, a high flash point, and is not a HAP nor listed under SARA 313. A risk associated with DMSO removers is that it is readily transported through the skin and may readily carry toxic compounds present with it. |
| Category | Organic Chemicals |
Documented applications: Uses: Used as a pharmaceutical, a solvent for polymerization and chemical extractions, a paint remover, a preservative for organ transplantation, Occurs naturally in ground water and in grains, vegetables, and many other foods, [CHEMINFO] Used as a solvent for many organic compounds, Also used in industrial cleaners, [HSDB], Semiconductor Manufacturing [Category: Industry], DMSO is not a nutritional supplement. It is used as a treatment for interstitial cystitis, and treatment must be performed by a qualified physician. DMSO is metabolized to methylsulfonylmethane, which is available as a nutritional supplement., Vitrification has become common for cryopreservation of embryos. ...Extended exposure of embryos with both vitrification protocols showed that the DMSO-containing vitrification solutions did not lead to cell membrane damage and death as quickly as the DMSO-free vitrification solutions. To assess embryo viability, the authors recommend that vitrification of early embryos should be combined with extended culture and assessment of normal blastocyst development before transferring to patients., Dimethyl sulfoxide (DMSO) is a molecule with a long history in pharmaceutics and is now well established as a penetration enhancer in topical pharmaceutical formulations. It is currently used for this purpose in diclofenac sodium topical solution (approved in the United States to treat signs and symptoms of osteoarthritis) and idoxuridine topical solution (approved in Europe for the treatment of herpes zoster). ... The clinical use of pharmaceutical-grade DMSO as a penetration enhancer is supported by the robust data that have accumulated over the past 3 decades demonstrating the favorable safety and tolerability profile. Dimethyl sulfoxide is a safe and effective mechanism for facilitating the transdermal delivery of both hydrophilic and lipophilic medications to provide localized drug delivery., For dimethyl sulfoxide (USEPA, OPP Pesticide Code: 000177) there are 0 labels match., SRP: Not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses., For more Uses (Complete) data for DIMETHYL SULFOXIDE (13 total), please visit the HSDB record page., Use (kg, approx.) in Germany (2009): >10000, Consumption (g per capita, approx.) in Germany (2009): 0.122, Excretion rate: 0.68, Calculated removal (%): 75.1, DMSO is an important polar aprotic solvent. In cryobiology DMSO has been used as a cryoprotectant and is still an important constituent of cryoprotectant vitrification mixtures used to preserve organs, tissues, and cell suspensions.[Wikipedia], Use Classification: Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients, Fragrance Ingredients, Flavouring Agent -> FLAVOURING_AGENT -> JECFA Functional Classes, Flavoring Agents -> JECFA Flavorings Index, SOLVENTS, Industry Uses: Laboratory chemicals, Etching agent, Not Known or Reasonably Ascertainable, Cleaning agent, Plating agent, Solvent, Consumer Uses: Solvent, Soil amendments (fertilizers), Household Products: Information on 1 consumer products that contain Dimethyl sulfoxide in the following categories is provided:, • Home Maintenance, Methods of Manufacturing: In industry, DMSO is produced by catalytic oxidation of dimethyl sulfide with oxygen or by oxidation with nitrogen dioxide. The oxidation of dimethyl sulfide with oxygen at 7.2 MPa and 105 °C gives good yields of DMSO., Obtained as a by-product of paper manufacture ... ., Oxidation of dimethyl sulfide with nitrogen tetroxide under anhydrous conditions, sulfide waste liquors., Formulations, Preparations: Rimso-50 (Research Industries) Solution: 50% aqueous solution., Dimethyl Sulfoxide (Bioniche), Solution: 50% aqueous solution, U.S. Production: 2023: 2, 500, 000 - <4, 000, 000 lb, 2022: 2, 2021: 2, 2020: 2, (1972) Probably greater than 4.54x10+5 g, (1975) probably greater than 4.54x10+5 g, Methane, sulfinylbis- is listed as a High Production Volume (HPV) chemical (65FR81686). Chemicals listed as HPV were produced in or imported into the U.S. in >1 million pounds in 1990 and, or 1994. The HPV list is based on the 1990 Inventory Update Rule. (IUR) (40 CFR part 710 subpart B, 51FR21438)., Production volumes for non-confidential chemicals reported under the Inventory Update Rule.[Table#221], For more U.S. Production (Complete) data for DIMETHYL SULFOXIDE (6 total), Computer and Electronic Product Manufacturing, Plastics Product Manufacturing, Transportation Equipment Manufacturing, Electrical Equipment, Appliance, and Component Manufacturing, Pharmaceutical and Medicine Manufacturing, All Other Basic Organic Chemical Manufacturing, Services, Machinery Manufacturing, Adhesive Manufacturing, Paint and Coating Manufacturing, Fabricated Metal Product Manufacturing, 1, 1'-sulfinylbis-: ACTIVE, FDA does not permit its use in horses or dogs intended for breeding purposes, nor in horses slaughtered for food., Dimethyl sulfoxide is used in many paint removers and has many green characteristics. It has low toxicity, a high flash point, and is not a HAP nor listed under SARA 313. A risk associated with DMSO removers is that it is readily transported through the skin and may readily carry toxic compounds present with it..
methylsulfinylmethane is a carbon-based organic compound with CAS registry number 67-68-5 and molecular formula C2H6OS (molecular weight 78.01 g/mol), belonging to the organic chemicals segment of chemical raw materials.
CAS number: 67-68-5
Its molecular formula C2H6OS comprises 2 C, 6 H, 1 O, 1 S atoms.
Also known as: methylsulfinylmethane · Dimethyl sulfoxide
Category: organic chemicals
The CAS registry number of methylsulfinylmethane is 67-68-5.
Molecular formula C2H6OS, molecular weight 78.01 g/mol.
It is also registered under: methylsulfinylmethane, Dimethyl sulfoxide.
Recorded applications: Uses: Used as a pharmaceutical, a solvent for polymerization and chemical extractions, a paint remover, a preservative for organ transplantation, Occurs naturally in ground water and in grains, vegetables, and many other foods, [CHEMINFO] Used as a solvent for many organic compounds, Also used in industrial cleaners, [HSDB], Semiconductor Manufacturing [Category: Industry], DMSO is not a nutritional supplement. It is used as a treatment for interstitial cystitis, and treatment must be performed by a qualified physician. DMSO is metabolized to methylsulfonylmethane, which is available as a nutritional supplement., Vitrification has become common for cryopreservation of embryos. ...Extended exposure of embryos with both vitrification protocols showed that the DMSO-containing vitrification solutions did not lead to cell membrane damage and death as quickly as the DMSO-free vitrification solutions. To assess embryo viability, the authors recommend that vitrification of early embryos should be combined with extended culture and assessment of normal blastocyst development before transferring to patients., Dimethyl sulfoxide (DMSO) is a molecule with a long history in pharmaceutics and is now well established as a penetration enhancer in topical pharmaceutical formulations. It is currently used for this purpose in diclofenac sodium topical solution (approved in the United States to treat signs and symptoms of osteoarthritis) and idoxuridine topical solution (approved in Europe for the treatment of herpes zoster). ... The clinical use of pharmaceutical-grade DMSO as a penetration enhancer is supported by the robust data that have accumulated over the past 3 decades demonstrating the favorable safety and tolerability profile. Dimethyl sulfoxide is a safe and effective mechanism for facilitating the transdermal delivery of both hydrophilic and lipophilic medications to provide localized drug delivery., For dimethyl sulfoxide (USEPA, OPP Pesticide Code: 000177) there are 0 labels match., SRP: Not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses., For more Uses (Complete) data for DIMETHYL SULFOXIDE (13 total), please visit the HSDB record page., Use (kg, approx.) in Germany (2009): >10000, Consumption (g per capita, approx.) in Germany (2009): 0.122, Excretion rate: 0.68, Calculated removal (%): 75.1, DMSO is an important polar aprotic solvent. In cryobiology DMSO has been used as a cryoprotectant and is still an important constituent of cryoprotectant vitrification mixtures used to preserve organs, tissues, and cell suspensions.[Wikipedia], Use Classification: Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients, Fragrance Ingredients, Flavouring Agent -> FLAVOURING_AGENT -> JECFA Functional Classes, Flavoring Agents -> JECFA Flavorings Index, SOLVENTS, Industry Uses: Laboratory chemicals, Etching agent, Not Known or Reasonably Ascertainable, Cleaning agent, Plating agent, Solvent, Consumer Uses: Solvent, Soil amendments (fertilizers), Household Products: Information on 1 consumer products that contain Dimethyl sulfoxide in the following categories is provided:, • Home Maintenance, Methods of Manufacturing: In industry, DMSO is produced by catalytic oxidation of dimethyl sulfide with oxygen or by oxidation with nitrogen dioxide. The oxidation of dimethyl sulfide with oxygen at 7.2 MPa and 105 °C gives good yields of DMSO., Obtained as a by-product of paper manufacture ... ., Oxidation of dimethyl sulfide with nitrogen tetroxide under anhydrous conditions, sulfide waste liquors., Formulations, Preparations: Rimso-50 (Research Industries) Solution: 50% aqueous solution., Dimethyl Sulfoxide (Bioniche), Solution: 50% aqueous solution, U.S. Production: 2023: 2, 500, 000 - <4, 000, 000 lb, 2022: 2, 2021: 2, 2020: 2, (1972) Probably greater than 4.54x10+5 g, (1975) probably greater than 4.54x10+5 g, Methane, sulfinylbis- is listed as a High Production Volume (HPV) chemical (65FR81686). Chemicals listed as HPV were produced in or imported into the U.S. in >1 million pounds in 1990 and, or 1994. The HPV list is based on the 1990 Inventory Update Rule. (IUR) (40 CFR part 710 subpart B, 51FR21438)., Production volumes for non-confidential chemicals reported under the Inventory Update Rule.[Table#221], For more U.S. Production (Complete) data for DIMETHYL SULFOXIDE (6 total), Computer and Electronic Product Manufacturing, Plastics Product Manufacturing, Transportation Equipment Manufacturing, Electrical Equipment, Appliance, and Component Manufacturing, Pharmaceutical and Medicine Manufacturing, All Other Basic Organic Chemical Manufacturing, Services, Machinery Manufacturing, Adhesive Manufacturing, Paint and Coating Manufacturing, Fabricated Metal Product Manufacturing, 1, 1'-sulfinylbis-: ACTIVE, FDA does not permit its use in horses or dogs intended for breeding purposes, nor in horses slaughtered for food., Dimethyl sulfoxide is used in many paint removers and has many green characteristics. It has low toxicity, a high flash point, and is not a HAP nor listed under SARA 313. A risk associated with DMSO removers is that it is readily transported through the skin and may readily carry toxic compounds present with it..
Category: Organic Chemicals.
Independent reference data for methylsulfinylmethane (CAS 67-68-5), compiled from public chemistry databases.
| CAS Registry Number | 67-68-5 |
|---|---|
| PubChem CID | 679 |
| Molecular formula | C2H6OS |
| Molecular weight | 78.01 g/mol |
| IUPAC name | methylsulfinylmethane |
| InChIKey | IAZDPXIOMUYVGZ-UHFFFAOYSA-N |
| UNII (FDA) | YOW8V9698H |
| ChEBI ID | CHEBI:28262 |
| ATC code (WHO) | G04BX13 |
| FEMA number | 3875 |
| JECFA number | 507 |
| Molecular Weight | 78.14 |
|---|---|
| XLogP3 | -0.6 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 0 |
| Exact Mass | 78.01393598 |
| Monoisotopic Mass | 78.01393598 |
| Topological Polar Surface Area | 36.3 |
| Heavy Atom Count | 4 |
| Boiling Point | 372 °F at 760 mmHg (NTP, 1992) |
|---|---|
| Boiling Point | 63 |
| Boiling Point | 189 °C |
| Boiling Point | 189.00 to 190.00 °C. @ 760.00 mm Hg |
| Boiling Point | 189 °C @760 [mm Hg] |
| Melting Point | 65.3 °F (NTP, 1992) |
| Melting Point | 18.5 |
| Melting Point | 18.45 °C |
| Melting Point | 18.5 °C |
| Melting Point | 17.89 °C |
dimethyl sulfoxide; 67-68-5; DMSO; Methylsulfinylmethane; Methyl sulfoxide; Dimethyl sulphoxide; Dimethylsulfoxide; sulfinylbismethane; Demasorb; Domoso; Methane, sulfinylbis-; Demsodrox; Dromisol; Deltan; Demavet; Demeso
| Regulatory & Food Contact | EU Flavoring substances FDA Substance added to food: FLAVORING AGENT OR ADJUVANT FDA Inventory of Food Contact Substances Listed in 21 CFR: FCS Flavoring Agents FLAVOURING_AGENT: Flavouring Agent Garlic |
|---|---|
| GHS notification summary | 65.1% (611 / 938) |
| GHS notification summary | 65.1% (611 / 938) |
|---|---|
| Reported hazard statements | H315 (28.4%), H319 (33.6%), H335 (13.8%), H227, H371 |
This chemical does not meet GHS hazard criteria for 65.1% (611 of 938) of all reports.
H315 (28.4%): Causes skin irritation [Warning Skin corrosion/irritation]
methylsulfinylmethane is identified by CAS 67-68-5, molecular formula C2H6OS and molecular weight 78.01 g/mol. UNII YOW8V9698H; ChEBI 28262; InChIKey IAZDPXIOMUYVGZ-UHFFFAOYSA-N. Boiling Point: 372 °F at 760 mmHg (NTP, 1992); Boiling Point: 63; Boiling Point: 189 °C.
Source: PubChem / Wikidata; the batch COA governs where values differ.
Supplier: Jinan Shenghe Chemical Co., Ltd.
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