二甲双胍

Description

Metformin · CAS 657-24-9 · C4H11N5. UNII 9100L32L2N. Boiling Point: 224.1ºC at 760 mmHg; Melting Point: 223-226 °C; Melting Point: 223 - 226 °C.

Identification

CAS Registry Number	657-24-9
PubChem CID	4091
Molecular formula	C4H11N5
IUPAC name	3-(diaminomethylidene)-1,1-dimethylguanidine
UNII (FDA)	9100L32L2N

Computed Descriptors

Molecular Weight	129.16
XLogP3	-1.3
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	2
Exact Mass	129.10144537
Monoisotopic Mass	129.10144537
Topological Polar Surface Area	91.5
Heavy Atom Count	9
Formal Charge	0

Physical & Chemical Properties

Boiling Point	224.1ºC at 760 mmHg
Melting Point	223-226 °C
Melting Point	223 - 226 °C
LogP	-2.6
Ionization Efficiency	3.49
Ionization Efficiency	2.7
Ionization Efficiency	MeCN (80%)
Dissociation Constants	12.4

Physical description & handling notes

• Solid
• Freely soluble
• Stable under recommended storage conditions. /Metformin hydrochloride/
• Hazardous decomposition products formed under fire conditions - Carbon oxides, nitrogen oxides (NOx), hydrogen chloride gas. /Metformin hydrochloride/
• When heated to decomposition it emits toxic fumes of /nitric oxides/.
• Positive

Regulatory Status

GHS notification summary	50% (2 / 4)

GHS Hazard Classification

GHS notification summary	50% (2 / 4)
Reported hazard statements	H302 (50%), H315, H319

Documented Uses

• Use (kg) in Switzerland (2009): >75000
• Use (kg; approx.) in Germany (2009): >1000000
• Use (kg) in USA (2002): 1450000
• Use (kg) in France (2004): 716858
• Consumption (g per capita) in Switzerland (2009): 9.6
• Consumption (g per capita; approx.) in Germany (2009): 12

Synonyms

metformin; 657-24-9; 1,1-Dimethylbiguanide; N,N-dimethylimidodicarbonimidic diamide; Metiguanide; Dimethylbiguanide; Metformine; N,N-Dimethylbiguanide; Metformina; N1,N1-Dimethylbiguanide; N,N-Dimethyldiguanide; 3-(diaminomethylidene)-1,1-dimethylguanidine; Diaformin; Dimethylbiguanid; Metformin extended release; BIGUANIDE, 1,1-DIMETHYL-

Frequently Asked Questions

What are the CAS number and molecular formula of Metformin?

CAS 657-24-9; molecular formula C4H11N5; molecular weight — g/mol.

What other names is Metformin known by?

metformin, 657-24-9, 1,1-Dimethylbiguanide, N,N-dimethylimidodicarbonimidic diamide, Metiguanide, Dimethylbiguanide.

Is Metformin classified as hazardous?

50% of GHS notifications report no hazard classification (2 of 4).

What are the key physical properties of Metformin?

Boiling Point: 224.1ºC at 760 mmHg; Melting Point: 223-226 °C; Melting Point: 223 - 226 °C; LogP: -2.6.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.