mesuximide

Description

mesuximide · CAS 77-41-8 · C12H13NO2. UNII 0G76K8X6C0. Boiling Point: 121.5; Boiling Point: 121-122 °C at 0.1 mm Hg; Melting Point: 52.5.

Identification

CAS Registry Number	77-41-8
PubChem CID	6476
Molecular formula	C12H13NO2
IUPAC name	1,3-dimethyl-3-phenylpyrrolidine-2,5-dione
UNII (FDA)	0G76K8X6C0

Computed Descriptors

Molecular Weight	203.24
XLogP3	1.2
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	1
Exact Mass	203.094628657
Monoisotopic Mass	203.094628657
Topological Polar Surface Area	37.4
Heavy Atom Count	15
Formal Charge	0

Physical & Chemical Properties

Boiling Point	121.5
Boiling Point	121-122 °C at 0.1 mm Hg
Melting Point	52.5
Melting Point	52-53 °C
Melting Point	52.5 °C
Solubility	2.13e+00 g/L

Physical description & handling notes

• Solid
• Crystals from dilute alcohol
• White to grayish white, crystalline powder
• Odorless to slight odor
• Freely sol in methanol, alcohol
• Slightly soluble in hot water; freely soluble in alcohol and ether; very soluble in chloroform.

GHS Hazard Classification

Reported hazard statements	H302 (100%), H412 (97.6%)

Documented Uses

• Use (kg; approx.) in Germany (2009): >100
• Consumption (g per capita; approx.) in Germany (2009): 0.00122
• For the control of absence (petit mal) seizures that are refractory to other drugs.
• 2-methyl-2-phenylsuccinic acid is dissolved in excess of 40% methylamine. Water & excess amine are distilled off & residue consisting of di(methylamine) salt of acid is pyrolized at about 250 °C until no more distillate is formed. Residue of crude methsuximide may be purified by vacuum dist or by...precipitation...
• Prepd by action of methylamine on alpha-methyl-alpha-phenylsuccinic acid.
• Acetophenone + ethyl cyanoacetate + hydrogen cyanide + methylamine (Cope reaction/addition/nitrile hydrolysis/decarboxylation/amide formation).

Synonyms

METHSUXIMIDE; Mesuximide; 77-41-8; Celontin; 1,3-dimethyl-3-phenylpyrrolidine-2,5-dione; Methsuximid; Metsuccimide; Mesuximidum; mesuximid; alpha-Methylphensuximide; N,2-Dimethyl-2-phenylsuccinimide; 1,3-Dimethyl-3-phenylsuccinimide; Mesuximida; Metosuccimmide; 1,3-Dimethyl-3-phenyl-2,5-dioxopyrrolidine; 1,3-Dimethyl-3-phenyl-pyrrolidin-2,5-dione

Frequently Asked Questions

What are the CAS number and molecular formula of mesuximide?

CAS 77-41-8; molecular formula C12H13NO2; molecular weight — g/mol.

What other names is mesuximide known by?

METHSUXIMIDE, Mesuximide, 77-41-8, Celontin, 1,3-dimethyl-3-phenylpyrrolidine-2,5-dione, Methsuximid.

Is mesuximide classified as hazardous?

Hazard statements reported: H302, H412.

What are the key physical properties of mesuximide?

Boiling Point: 121.5; Boiling Point: 121-122 °C at 0.1 mm Hg; Melting Point: 52.5; Melting Point: 52-53 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.