洛索洛芬

Description

Loxoprofen · CAS 68767-14-6 · C15H18O3. UNII 3583H0GZAP. Boiling Point: 220.7; Melting Point: 108.5; Solubility: 47.

Identification

CAS Registry Number	68767-14-6
PubChem CID	3965
Molecular formula	C15H18O3
IUPAC name	2-[4-[(2-oxocyclopentyl)methyl]phenyl]propanoic acid
UNII (FDA)	3583H0GZAP

Computed Descriptors

Molecular Weight	246.30
XLogP3	2.4
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	4
Exact Mass	246.125594432
Monoisotopic Mass	246.125594432
Topological Polar Surface Area	54.4
Heavy Atom Count	18
Formal Charge	0

Physical & Chemical Properties

Boiling Point	220.7
Melting Point	108.5
Solubility	47

Physical description & handling notes

• Loxoprofen is a non-selective inhibitor of cyclooxygenase enzymes, which are responsible for the formation of various biologically active pain, fever, and inflammatory mediators. These include prostaglandins, prostacyclin, thromboxane, and arachidonic acid.

Documented Uses

• Loxoprofen is non-steroidal anti-inflammatory medication (NSAID) indicated for pain and inflammation related to musculoskeletal and joint disorders. In addition to its effects on pain, it is an antipyretic and anti-inflammatory medication.
• Exercise caution with grapefruit products. Loxoprofen is metabolized by CYP3A4 to an inactive metabolite and grapefruit is a CYP3A4 inhibitor.
• Exercise caution with St. John's Wort. Loxoprofen is metabolized by CYP3A4 to an inactive metabolite and St. Johns Wort is a CYP3A4 inducer.
• Take with food. Taking loxoprofen with food may reduce the risk of gastrointestinal upset.
• Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
• M02 - Topical products for joint and muscular pain

Synonyms

Loxoprofen; 68767-14-6; 2-(4-((2-Oxocyclopentyl)methyl)phenyl)propanoic acid; Loxoprofene; Loxoprofeno; Loxoprofen acid; Loxoprofenum; 2-{4-[(2-oxocyclopentyl)methyl]phenyl}propanoic acid; 2-[4-[(2-oxocyclopentyl)methyl]phenyl]propanoic acid; 3583H0GZAP; DTXSID1045164; CS-600; DTXCID9025164; CHEBI:76172; 2-(4-((2-oxocyclopentyl)methyl)phenyl)propionic acid; 2-OCPPP

Frequently Asked Questions

What are the CAS number and molecular formula of Loxoprofen?

CAS 68767-14-6; molecular formula C15H18O3; molecular weight — g/mol.

What other names is Loxoprofen known by?

Loxoprofen, 68767-14-6, 2-(4-((2-Oxocyclopentyl)methyl)phenyl)propanoic acid, Loxoprofene, Loxoprofeno, Loxoprofen acid.

What are the key physical properties of Loxoprofen?

Boiling Point: 220.7; Melting Point: 108.5; Solubility: 47.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.