Losartan (CAS 114798-26-4) — formula C22H23ClN6O, molecular weight 422.9; category organic chemicals.
| CAS Number | 114798-26-4 |
|---|---|
| Molecular Formula | C22H23ClN6O |
| Molecular Weight | 422.9 |
| Melting Point | 178-184 |
| Boiling Point | 682 |
| LogP | 1.19 |
| Applications | Uses: Angiotensin II Type 1 Receptor Blockers, Anti-Arrhythmia Agents, Antihypertensive Agents, MEDICATION, Use (kg, approx.) in Germany (2009): >5000, Use (kg) in USA (2002): 27800, Consumption (g per capita, approx.) in Germany (2009): 0.0611, Consumption (g per capita) in the USA (2002): 0.0986, Excretion rate: 0.04, Calculated removal (%): 67, Use Classification: Pharmaceuticals, Pharmaceuticals -> Cardiovascular system -> Antihypertensions, Methods of Manufacturing: Preparation: D. J. Carini, J. J. V. Duncia, European Patent Office patent 253310, D. J. Carini et al, United States of America patent 5138069 (1988, 1992 both to Du Pont)., Formulations, Preparations: Table: Losartan Potassium Preparations [Table#6662], Table: Losartan Potassium Combination Preparations [Table#6663], General Manufacturing Information: The main ingredient in the drug Cozaar ... (tablets), The main ingredient in the drug Hyzaar ... (tablets), Losartan potassium - hydrochlorothiazide |
| Category | Organic Chemicals |
Documented applications: Uses: Angiotensin II Type 1 Receptor Blockers, Anti-Arrhythmia Agents, Antihypertensive Agents, MEDICATION, Use (kg, approx.) in Germany (2009): >5000, Use (kg) in USA (2002): 27800, Consumption (g per capita, approx.) in Germany (2009): 0.0611, Consumption (g per capita) in the USA (2002): 0.0986, Excretion rate: 0.04, Calculated removal (%): 67, Use Classification: Pharmaceuticals, Pharmaceuticals -> Cardiovascular system -> Antihypertensions, Methods of Manufacturing: Preparation: D. J. Carini, J. J. V. Duncia, European Patent Office patent 253310, D. J. Carini et al, United States of America patent 5138069 (1988, 1992 both to Du Pont)., Formulations, Preparations: Table: Losartan Potassium Preparations [Table#6662], Table: Losartan Potassium Combination Preparations [Table#6663], General Manufacturing Information: The main ingredient in the drug Cozaar ... (tablets), The main ingredient in the drug Hyzaar ... (tablets), Losartan potassium - hydrochlorothiazide.
Losartan is a carbon-based organic compound with CAS registry number 114798-26-4 and molecular formula C22H23ClN6O (molecular weight 422.9), belonging to the organic chemicals segment of chemical raw materials.
CAS number: 114798-26-4
Its molecular formula C22H23ClN6O comprises 22 C, 23 H, 1 Cl, 6 N, 1 O atoms.
Also known as: Losartan · 洛沙坦
Category: organic chemicals
The CAS registry number of Losartan is 114798-26-4.
Molecular formula C22H23ClN6O, molecular weight 422.9.
It is also registered under: Losartan, 洛沙坦.
Recorded applications: Uses: Angiotensin II Type 1 Receptor Blockers, Anti-Arrhythmia Agents, Antihypertensive Agents, MEDICATION, Use (kg, approx.) in Germany (2009): >5000, Use (kg) in USA (2002): 27800, Consumption (g per capita, approx.) in Germany (2009): 0.0611, Consumption (g per capita) in the USA (2002): 0.0986, Excretion rate: 0.04, Calculated removal (%): 67, Use Classification: Pharmaceuticals, Pharmaceuticals -> Cardiovascular system -> Antihypertensions, Methods of Manufacturing: Preparation: D. J. Carini, J. J. V. Duncia, European Patent Office patent 253310, D. J. Carini et al, United States of America patent 5138069 (1988, 1992 both to Du Pont)., Formulations, Preparations: Table: Losartan Potassium Preparations [Table#6662], Table: Losartan Potassium Combination Preparations [Table#6663], General Manufacturing Information: The main ingredient in the drug Cozaar ... (tablets), The main ingredient in the drug Hyzaar ... (tablets), Losartan potassium - hydrochlorothiazide.
Category: Organic Chemicals.
Independent reference data for Losartan (CAS 114798-26-4), compiled from public chemistry databases.
| CAS Registry Number | 114798-26-4 |
|---|---|
| PubChem CID | 3961 |
| Molecular formula | C22H23ClN6O |
| IUPAC name | [2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol |
| UNII (FDA) | JMS50MPO89 |
| Molecular Weight | 422.9 |
|---|---|
| XLogP3 | 4.3 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 8 |
| Exact Mass | 422.1621871 |
| Monoisotopic Mass | 422.1621871 |
| Topological Polar Surface Area | 92.5 |
| Heavy Atom Count | 30 |
| Boiling Point | 682 |
|---|---|
| Melting Point | 178-184 |
| Melting Point | 183.5-184.5 °C |
| Melting Point | 183.5 - 184.5 °C |
| Solubility | <1mg/mL |
| Solubility | 4.70e-03 g/L |
| LogP | 1.19 |
| LogP | 6.1 |
| LogP | 2.53 |
| Dissociation Constants | 5.5 |
losartan; 114798-26-4; allisartan; Angizaar; Losartic; Lozap; DUP-89; DTXSID7023227; [2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol; JMS50MPO89; NSC-758699; CHEBI:6541; HGP1405; HGP-1405; 2-Butyl-4-chloro-1-((2'-(1H-etrazol-5-yl) (1,1'-biphenyl)-4-yl)methyl)-1H-imidazole-5-methanol; DTXCID103227
| Reported hazard statements | H315 (48.1%), H317 (48.1%), H319 (49.4%), H335 (48.1%), H360 (46.9%), H362 (46.9%), H413 (46.9%) |
|---|
H315 (48.1%): Causes skin irritation [Warning Skin corrosion/irritation]
H317 (48.1%): May cause an allergic skin reaction [Warning Sensitization, Skin]
Losartan · CAS 114798-26-4 · C22H23ClN6O. UNII JMS50MPO89. Boiling Point: 682; Melting Point: 178-184; Melting Point: 183.5-184.5 °C.
Source: PubChem / Wikidata; the batch COA governs where values differ.
Supplier: Jinan Shenghe Chemical Co., Ltd.
中文页面: 洛沙坦