Lapatinib ditosylate monohydrate (CAS 388082-78-8) — formula C29H26ClFN4O4S, molecular weight 581.1; category organic chemicals.
| CAS Number | 388082-78-8 |
|---|---|
| Molecular Formula | C29H26ClFN4O4S |
| Molecular Weight | 581.1 |
| LogP | 5.4 |
| Applications | Uses: MEDICATION, Antineoplastic Agents, Protein Kinase Inhibitors, Use (kg, approx.) in Germany (2009): >250, exact) in Germany (2009): 287, Consumption (g per capita, approx.) in Germany (2009): 0.00305, exact) in Germany (2009): 0.0035, Calculated removal (%): 85, Methods of Manufacturing: The synthesis route for, lapatinib, ... involves a Suzuki coupling of 5-formyl-2-furanboronic acid with the iodo-substituted quinazoline derivative., Preparation: M. C. Carter et al., World Intellectual Property Organization patent 9935146 (1999 to Glaxo), eidem, United States of America patent 6727256 (2004 to SmithKline Beecham)., Formulations, Preparations: Oral: Tablets, film-coated: 250 mg (of lapatinib), Tykerb (GlaxoSmithKline). |
| Category | Organic Chemicals |
Documented applications: Uses: MEDICATION, Antineoplastic Agents, Protein Kinase Inhibitors, Use (kg, approx.) in Germany (2009): >250, exact) in Germany (2009): 287, Consumption (g per capita, approx.) in Germany (2009): 0.00305, exact) in Germany (2009): 0.0035, Calculated removal (%): 85, Methods of Manufacturing: The synthesis route for, lapatinib, ... involves a Suzuki coupling of 5-formyl-2-furanboronic acid with the iodo-substituted quinazoline derivative., Preparation: M. C. Carter et al., World Intellectual Property Organization patent 9935146 (1999 to Glaxo), eidem, United States of America patent 6727256 (2004 to SmithKline Beecham)., Formulations, Preparations: Oral: Tablets, film-coated: 250 mg (of lapatinib), Tykerb (GlaxoSmithKline)..
Lapatinib ditosylate monohydrate is a carbon-based organic compound with CAS registry number 388082-78-8 and molecular formula C29H26ClFN4O4S (molecular weight 581.1), belonging to the organic chemicals segment of chemical raw materials.
CAS number: 388082-78-8
Its molecular formula C29H26ClFN4O4S comprises 29 C, 26 H, 1 Cl, 1 F, 4 N, 4 O, 1 S atoms.
Also known as: Lapatinib ditosylate monohydrate · 二甲苯磺酸拉帕替尼一水合物
Category: organic chemicals
The CAS registry number of Lapatinib ditosylate monohydrate is 388082-78-8.
Molecular formula C29H26ClFN4O4S, molecular weight 581.1.
It is also registered under: Lapatinib ditosylate monohydrate, 二甲苯磺酸拉帕替尼一水合物.
Recorded applications: Uses: MEDICATION, Antineoplastic Agents, Protein Kinase Inhibitors, Use (kg, approx.) in Germany (2009): >250, exact) in Germany (2009): 287, Consumption (g per capita, approx.) in Germany (2009): 0.00305, exact) in Germany (2009): 0.0035, Calculated removal (%): 85, Methods of Manufacturing: The synthesis route for, lapatinib, ... involves a Suzuki coupling of 5-formyl-2-furanboronic acid with the iodo-substituted quinazoline derivative., Preparation: M. C. Carter et al., World Intellectual Property Organization patent 9935146 (1999 to Glaxo), eidem, United States of America patent 6727256 (2004 to SmithKline Beecham)., Formulations, Preparations: Oral: Tablets, film-coated: 250 mg (of lapatinib), Tykerb (GlaxoSmithKline)..
Category: Organic Chemicals.
Independent reference data for Lapatinib ditosylate monohydrate (CAS 388082-78-8), compiled from public chemistry databases.
| CAS Registry Number | 388082-78-8 |
|---|---|
| PubChem CID | 208908 |
| Molecular formula | C29H26ClFN4O4S |
| IUPAC name | N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine |
| UNII (FDA) | 0VUA21238F |
| Molecular Weight | 581.1 |
|---|---|
| XLogP3 | 5.1 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 9 |
| Rotatable Bond Count | 11 |
| Exact Mass | 580.1347324 |
| Monoisotopic Mass | 580.1347324 |
| Topological Polar Surface Area | 115 |
| Heavy Atom Count | 40 |
| Solubility | 2.23e-02 g/L |
|---|---|
| LogP | 5.4 |
Lapatinib; 231277-92-2; GW572016; GW 572016; GSK 572016; DTXSID7046675; GW-572016; GSK572016; GSK-572016; 0VUA21238F; GW-572016X; DTXCID5026675; CHEBI:49603; GW2016; lapatinibum; RefChem:798502
| Reported hazard statements | H319 (50%), H362 (100%), H413 (100%) |
|---|
H319 (50%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H362 (100%): May cause harm to breast-fed children [Reproductive toxicity, effects on or via lactation]
Lapatinib ditosylate monohydrate · CAS 388082-78-8 · C29H26ClFN4O4S. UNII 0VUA21238F. Solubility: 2.23e-02 g/L; LogP: 5.4.
Source: PubChem / Wikidata; the batch COA governs where values differ.
Supplier: Jinan Shenghe Chemical Co., Ltd.
中文页面: 二甲苯磺酸拉帕替尼一水合物