L-3-(3,4-二羟基苯基)丙氨酸（CAS 65170-01-6）：分子式 C9H11NO4、分子量 197.19。
| CAS号 | 65170-01-6 |
|---|---|
| 分子式 | C9H11NO4 |
| 分子量 | 197.19 |
| 熔点 | 295 |
| 沸点 | 448.4 |
| LogP | 0.05 |
| 应用领域 | Uses: Natural form of dopa (precursor of the catecholamines)、Used to treat Parkinson's disease、[Merck Index]、MEDICATION、Use (kg) in Switzerland (2009): >2500、Use (kg、approx.) in Germany (2009): >25000、Use (kg) in USA (2002): 26200、Use (kg) in France (2004): 24996、Consumption (g per capita) in Switzerland (2009): 0.32、Consumption (g per capita、approx.) in Germany (2009): 0.31、Consumption (g per capita) in the USA (2002): 0.093、Consumption (g per capita) in France (2004): 0.41、Excretion rate: 0.5、Calculated removal (%): 75.1、For the treatment of idiopathic Parkinson's disease (Paralysis Agitans)、postencephalitic parkinsonism、symptomatic parkinsonism which may follow injury to the nervous system by carbon monoxide intoxication、and manganese intoxication.、Use Classification: Pharmaceuticals、Methods of Manufacturing: Derived from several types of beans including vanilla.、Preparation from L-tyrosine: Vorbruggen、Krolikiewicz、Ber. 105、1168 (1972)、Bretschneider et al.、Helv. Chim. Acta 56、2857 (1973)、from Vicia faba beans: Wysong、US 3253023 (1966 to Dow Chem.)、by fermentation of L-tyrosine: Sih et al.、J. Am. Chem. Soc. 91、6204 (1969)、Florent、Renaut、DE 2102793 (1971 to Rhone-Poulenc)、C.A. 75、108505f (1971). Separation from racemate: Vogler、Baumgartner、Helv. Chim. Acta 35、1776 (1952)、NL 6514950、US 3405159 (1966、1968 both to Merck & Co.)、Production: glycine + acetic anhydride + vanillin (amide formation、carbonyl condensation、chiral catalytic hydrogenation、hydrolysis. Production: 2、4-dihydroxybenzaldehyde + hydrogen cyanide + ammonia (Strecker synthesis、racemate separation). Production: catechol + pyruvic acid + ammonia (microbial conversion)、Formulations、Preparations: CAPSULES USP: 100、250、& 500 MG、TABLETS USP: 100、& 500 MG.、Levodopa is one of the main ingredients along with carbidopa in the drug Sinemet ... (tablets)、Levodopa is one of the main ingredients along with carbidopa in the drug Atamet ... (tablets)、General Manufacturing Information: L-Tyrosine、3-hydroxy-: ACTIVE |
登记用途：Uses: Natural form of dopa (precursor of the catecholamines)、Used to treat Parkinson's disease、[Merck Index]、MEDICATION、Use (kg) in Switzerland (2009): >2500、Use (kg、approx.) in Germany (2009): >25000、Use (kg) in USA (2002): 26200、Use (kg) in France (2004): 24996、Consumption (g per capita) in Switzerland (2009): 0.32、Consumption (g per capita、approx.) in Germany (2009): 0.31、Consumption (g per capita) in the USA (2002): 0.093、Consumption (g per capita) in France (2004): 0.41、Excretion rate: 0.5、Calculated removal (%): 75.1、For the treatment of idiopathic Parkinson's disease (Paralysis Agitans)、postencephalitic parkinsonism、symptomatic parkinsonism which may follow injury to the nervous system by carbon monoxide intoxication、and manganese intoxication.、Use Classification: Pharmaceuticals、Methods of Manufacturing: Derived from several types of beans including vanilla.、Preparation from L-tyrosine: Vorbruggen、Krolikiewicz、Ber. 105、1168 (1972)、Bretschneider et al.、Helv. Chim. Acta 56、2857 (1973)、from Vicia faba beans: Wysong、US 3253023 (1966 to Dow Chem.)、by fermentation of L-tyrosine: Sih et al.、J. Am. Chem. Soc. 91、6204 (1969)、Florent、Renaut、DE 2102793 (1971 to Rhone-Poulenc)、C.A. 75、108505f (1971). Separation from racemate: Vogler、Baumgartner、Helv. Chim. Acta 35、1776 (1952)、NL 6514950、US 3405159 (1966、1968 both to Merck & Co.)、Production: glycine + acetic anhydride + vanillin (amide formation、carbonyl condensation、chiral catalytic hydrogenation、hydrolysis. Production: 2、4-dihydroxybenzaldehyde + hydrogen cyanide + ammonia (Strecker synthesis、racemate separation). Production: catechol + pyruvic acid + ammonia (microbial conversion)、Formulations、Preparations: CAPSULES USP: 100、250、& 500 MG、TABLETS USP: 100、& 500 MG.、Levodopa is one of the main ingredients along with carbidopa in the drug Sinemet ... (tablets)、Levodopa is one of the main ingredients along with carbidopa in the drug Atamet ... (tablets)、General Manufacturing Information: L-Tyrosine、3-hydroxy-: ACTIVE。
L-3-(3,4-二羟基苯基)丙氨酸 是一种化工化合物，登记 CAS 号为 65170-01-6，分子式 C9H11NO4（分子量 197.19）。
登记 CAS 号：65170-01-6
其分子式 C9H11NO4 由 9 个碳、11 个氢、1 个氮、4 个氧 组成。
别名/同义词：L-3-(3,4-二羟基苯基)丙氨酸 · L-3-(3,4-Dihydroxyphenyl)alanine
L-3-(3,4-二羟基苯基)丙氨酸 的 CAS 登记号为 65170-01-6。
分子式 C9H11NO4，分子量 197.19。
别名/同义词：L-3-(3,4-二羟基苯基)丙氨酸、L-3-(3,4-Dihydroxyphenyl)alanine。
登记用途：Uses: Natural form of dopa (precursor of the catecholamines)、Used to treat Parkinson's disease、[Merck Index]、MEDICATION、Use (kg) in Switzerland (2009): >2500、Use (kg、approx.) in Germany (2009): >25000、Use (kg) in USA (2002): 26200、Use (kg) in France (2004): 24996、Consumption (g per capita) in Switzerland (2009): 0.32、Consumption (g per capita、approx.) in Germany (2009): 0.31、Consumption (g per capita) in the USA (2002): 0.093、Consumption (g per capita) in France (2004): 0.41、Excretion rate: 0.5、Calculated removal (%): 75.1、For the treatment of idiopathic Parkinson's disease (Paralysis Agitans)、postencephalitic parkinsonism、symptomatic parkinsonism which may follow injury to the nervous system by carbon monoxide intoxication、and manganese intoxication.、Use Classification: Pharmaceuticals、Methods of Manufacturing: Derived from several types of beans including vanilla.、Preparation from L-tyrosine: Vorbruggen、Krolikiewicz、Ber. 105、1168 (1972)、Bretschneider et al.、Helv. Chim. Acta 56、2857 (1973)、from Vicia faba beans: Wysong、US 3253023 (1966 to Dow Chem.)、by fermentation of L-tyrosine: Sih et al.、J. Am. Chem. Soc. 91、6204 (1969)、Florent、Renaut、DE 2102793 (1971 to Rhone-Poulenc)、C.A. 75、108505f (1971). Separation from racemate: Vogler、Baumgartner、Helv. Chim. Acta 35、1776 (1952)、NL 6514950、US 3405159 (1966、1968 both to Merck & Co.)、Production: glycine + acetic anhydride + vanillin (amide formation、carbonyl condensation、chiral catalytic hydrogenation、hydrolysis. Production: 2、4-dihydroxybenzaldehyde + hydrogen cyanide + ammonia (Strecker synthesis、racemate separation). Production: catechol + pyruvic acid + ammonia (microbial conversion)、Formulations、Preparations: CAPSULES USP: 100、250、& 500 MG、TABLETS USP: 100、& 500 MG.、Levodopa is one of the main ingredients along with carbidopa in the drug Sinemet ... (tablets)、Levodopa is one of the main ingredients along with carbidopa in the drug Atamet ... (tablets)、General Manufacturing Information: L-Tyrosine、3-hydroxy-: ACTIVE。
L-3-(3,4-二羟基苯基)丙氨酸（CAS 65170-01-6）的独立参考数据，整理自公开化学数据库。
| CAS Registry Number | 65170-01-6 |
|---|---|
| PubChem CID | 6047 |
| Molecular formula | C9H11NO4 |
| IUPAC name | (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid |
| UNII (FDA) | 46627O600J |
| Molecular Weight | 197.19 |
|---|---|
| XLogP3 | -2.7 |
| Hydrogen Bond Donor Count | 4 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 3 |
| Exact Mass | 197.06880783 |
| Monoisotopic Mass | 197.06880783 |
| Topological Polar Surface Area | 104 |
| Heavy Atom Count | 14 |
| Boiling Point | 448.4 |
|---|---|
| Melting Point | 295 |
| Melting Point | 284-286 °C |
| Melting Point | 285 °C |
| Solubility | 5mM |
| Solubility | In water, 5,000 mg/l @ 20 °C |
| Solubility | 5.0 mg/mL |
| LogP | 0.05 |
| LogP | log Kow = -2.39 |
| LogP | -2.39 |
levodopa; L-dopa; 59-92-7; 3,4-dihydroxy-L-phenylalanine; Dopar; 3-Hydroxy-L-tyrosine; Larodopa; Bendopa; 3-(3,4-Dihydroxyphenyl)-L-alanine; Levopa; Brocadopa; Dopaidan; Dopalina; Dopasol; Eldopal; Insulamina
| Reported hazard statements | H302 (100%), H315 (32.2%), H319 (52.9%), H335 (30.8%), H361 (30.3%), H372 (14.4%), H411 (26.9%), H412 (15.9%) |
|---|
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
H315 (32.2%): Causes skin irritation [Warning Skin corrosion/irritation]
L-3-(3,4-Dihydroxyphenyl)alanine · CAS 65170-01-6 · C9H11NO4. UNII 46627O600J. Boiling Point: 448.4; Melting Point: 295; Melting Point: 284-286 °C.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: L-3-(3,4-Dihydroxyphenyl)alanine