伊斯拉韦

Description

Islatravir · CAS 865363-93-5 · C12H12FN5O3. UNII QPQ082R25D.

Identification

CAS Registry Number	865363-93-5
PubChem CID	6483431
Molecular formula	C12H12FN5O3
IUPAC name	(2R,3S,5R)-5-(6-amino-2-fluoropurin-9-yl)-2-ethynyl-2-(hydroxymethyl)oxolan-3-ol
UNII (FDA)	QPQ082R25D

Computed Descriptors

Molecular Weight	293.25
XLogP3	-0.6
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	3
Exact Mass	293.09241742
Monoisotopic Mass	293.09241742
Topological Polar Surface Area	119
Heavy Atom Count	21
Formal Charge	0

GHS Hazard Classification

Reported hazard statements	H301 (100%), H371 (100%), H373 (100%)

Documented Uses

• Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.
• Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
• Inhibitors of reverse transcriptase (RNA-DIRECTED DNA POLYMERASE), an enzyme that synthesizes DNA on an RNA template.
• Compounds that inhibit cell production of DNA or RNA.
• Agents used to treat RETROVIRIDAE INFECTIONS.

Synonyms

Islatravir; 865363-93-5; 2'-deoxy-4'-C-ethynyl-2-fluoroadenosine; 2'-Deoxy-4'-ethynyl-2-fluoroadenosine; MK8591; QPQ082R25D; DTXSID601046407; islatravirum; RefChem:908409; 4'Ed2FA; DTXCID301528226; EFdA; 4'-Ethynyl-2-Fluoro-2'-Deoxyadenosine; MK-8591; (2R,3S,5R)-5-(6-amino-2-fluoropurin-9-yl)-2-ethynyl-2-(hydroxymethyl)oxolan-3-ol; Islatravir [USAN]

Frequently Asked Questions

What are the CAS number and molecular formula of Islatravir?

CAS 865363-93-5; molecular formula C12H12FN5O3; molecular weight — g/mol.

What other names is Islatravir known by?

Islatravir, 865363-93-5, 2'-deoxy-4'-C-ethynyl-2-fluoroadenosine, 2'-Deoxy-4'-ethynyl-2-fluoroadenosine, MK8591, QPQ082R25D.

Is Islatravir classified as hazardous?

Hazard statements reported: H301, H371, H373.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.