Hydrocortisone acetate

Description

Hydrocortisone acetate · CAS 50-03-3 · C23H32O6. UNII 3X7931PO74. Collision Cross Section: 196.5 Ų [M-H]-; Collision Cross Section: 207 Ų [M+K]+; Collision Cross Section: 202.9 Ų [M+Na]+.

Identification

CAS Registry Number	50-03-3
PubChem CID	5744
Molecular formula	C23H32O6
IUPAC name	[2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
UNII (FDA)	3X7931PO74

Computed Descriptors

Molecular Weight	404.5
XLogP3	2.2
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	4
Exact Mass	404.21988874
Monoisotopic Mass	404.21988874
Topological Polar Surface Area	101
Heavy Atom Count	29
Formal Charge	0

Physical & Chemical Properties

Collision Cross Section	196.5 Ų [M-H]-
Collision Cross Section	207 Ų [M+K]+
Collision Cross Section	202.9 Ų [M+Na]+
Collision Cross Section	198.7 Ų [M+H]+

Physical description & handling notes

• 207.2 Ų [M+K]+ [CCS Type: DT; Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]
• 196.3 Ų [M-H]- [CCS Type: DT; Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]
• 198.8 Ų [M+H]+ [CCS Type: DT; Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]
• 203 Ų [M+Na]+ [CCS Type: DT; Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]
• 196.1 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

GHS Hazard Classification

Reported hazard statements	H302 (11.4%), H312 (10.9%), H332 (10.9%), H361 (92%)

Documented Uses

• Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
• Information on 1 consumer products that contain Hydrocortisone acetate in the following categories is provided:
• For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many immune and allergic disorders, such as arthritis, lupus, severe psoriasis, severe asthma, ulcerative colitis, and Crohn's disease.
• Substances that reduce or suppress INFLAMMATION.
• Corticosteroid Hormone Receptor Agonists [MoA]; Corticosteroid [EPC]
• Corticosteroid [EPC]; Corticosteroid Hormone Receptor Agonists [MoA]

Synonyms

hydrocortisone acetate; 50-03-3; Cortisol 21-acetate; Hydrocortisone 21-acetate; Cortell; Cortef acetate; Cortisol acetate; Cortifoam; Lanacort; Carmol HC; Dricort; Micort-hc; Hemsol-HC; Orabase HCA; U-CORT; NSC-741

Frequently Asked Questions

What are the CAS number and molecular formula of Hydrocortisone acetate?

CAS 50-03-3; molecular formula C23H32O6; molecular weight — g/mol.

What other names is Hydrocortisone acetate known by?

hydrocortisone acetate, 50-03-3, Cortisol 21-acetate, Hydrocortisone 21-acetate, Cortell, Cortef acetate.

Is Hydrocortisone acetate classified as hazardous?

Hazard statements reported: H302, H312, H332, H361.

What are the key physical properties of Hydrocortisone acetate?

Collision Cross Section: 196.5 Ų [M-H]-; Collision Cross Section: 207 Ų [M+K]+; Collision Cross Section: 202.9 Ų [M+Na]+; Collision Cross Section: 198.7 Ų [M+H]+.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.