Hydrocortisone

Description

Hydrocortisone · CAS 50-23-7 · C21H30O5. UNII WI4X0X7BPJ. Melting Point: 220; Melting Point: 220 °C; Solubility: 320.

Identification

CAS Registry Number	50-23-7
PubChem CID	5754
Molecular formula	C21H30O5
IUPAC name	(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
UNII (FDA)	WI4X0X7BPJ

Computed Descriptors

Molecular Weight	362.5
XLogP3	1.6
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	2
Exact Mass	362.20932405
Monoisotopic Mass	362.20932405
Topological Polar Surface Area	94.8
Heavy Atom Count	26
Formal Charge	0

Physical & Chemical Properties

Melting Point	220
Melting Point	220 °C
Solubility	320
Solubility	In water, 320 mg/L at 25 °C
Solubility	0.32 mg/mL
LogP	1.61
LogP	log Kow = 1.61
Collision Cross Section	188.95 Ų [M+Cl]-
Collision Cross Section	187.79 Ų [M+H]+
Collision Cross Section	191.98 Ų [M-H]-

Physical description & handling notes

• Solid
• Plates from alc or iso-propyl alc
• Crystalline, striated blocks from absolute ethanol or isopropanol
• White, crystalline powder
• Odorless
• Bitter taste

Regulatory Status

GHS notification summary	1.1% (3 / 274)

GHS Hazard Classification

GHS notification summary	1.1% (3 / 274)
Reported hazard statements	H361 (86.5%), H373 (31.8%)

Documented Uses

• Medicine (antiinflammatory agent), also used as the acetate and sodium succinate salts
• THERAP CAT (VET): Glucocorticoid
• Use (kg; approx.) in Germany (2009): >1000
• Consumption (g per capita; approx.) in Germany (2009): 0.0122
• Consumption (g per capita) in the USA (2002): 0.0744
• Consumption (g per capita) in France (2004): 0.0075

Synonyms

hydrocortisone; Cortisol; 50-23-7; Acticort; Cetacort; Hydrocortisyl; Cobadex; Hytone; Cortenema; Dermacort; Proctocort; Tarcortin; Cort-Dome; Efcorbin; Hycortol; Signef

Frequently Asked Questions

What are the CAS number and molecular formula of Hydrocortisone?

CAS 50-23-7; molecular formula C21H30O5; molecular weight — g/mol.

What other names is Hydrocortisone known by?

hydrocortisone, Cortisol, 50-23-7, Acticort, Cetacort, Hydrocortisyl.

Is Hydrocortisone classified as hazardous?

1.1% of GHS notifications report no hazard classification (3 of 274).

What are the key physical properties of Hydrocortisone?

Melting Point: 220; Melting Point: 220 °C; Solubility: 320; Solubility: In water, 320 mg/L at 25 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.