六甲基磷酰胺

Description

Hexamethylphosphoramide · CAS 680-31-9 · C6H18N3OP. UNII M42TU5843Z. Boiling Point: 451 °F at 760 mmHg (NTP, 1992); Boiling Point: 233 °C @ 760 MM HG; Boiling Point: 232 °C.

Identification

CAS Registry Number	680-31-9
PubChem CID	12679
Molecular formula	C6H18N3OP
IUPAC name	N-[bis(dimethylamino)phosphoryl]-N-methylmethanamine
UNII (FDA)	M42TU5843Z

Computed Descriptors

Molecular Weight	179.20
XLogP3	0.3
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	3
Exact Mass	179.11874920
Monoisotopic Mass	179.11874920
Topological Polar Surface Area	26.8
Heavy Atom Count	11
Formal Charge	0

Physical & Chemical Properties

Boiling Point	451 °F at 760 mmHg (NTP, 1992)
Boiling Point	233 °C @ 760 MM HG
Boiling Point	232 °C
Boiling Point	451 °F
Boiling Point	232.5 °C @760 [mm Hg]
Melting Point	41 to 45 °F (NTP, 1992)
Melting Point	FP: 5-7 °C
Melting Point	7.2 °C
Melting Point	43 °F
Flash Point	222 °F (NTP, 1992)

Physical description & handling notes

• Hexamethylphosphoramide is a clear colorless to light amber liquid with a spicy odor. (NTP, 1992)
• Clear, colorless liquid with an aromatic or mild, amine-like odor. [Note: A solid below 43 degrees F.]; [NIOSH]
• COLOURLESS MOBILE LIQUID.
• Clear, colorless to light amber liquid with an aromatic or mild, amine-like odor.
• COLORLESS, MOBILE LIQUID
• Clear, colorless liquid [Note: A solid below 43 degrees F].

GHS Hazard Classification

Reported hazard statements	H340, H350, H303, H313, H315, H351, H361, H371

Documented Uses

• Hexamethylphosphoramide is no longer used in large quantities in the United States. Hexamethylphosphoramide was used in the past as a selective solvent for gases, a polymerization catalyst, a stabilizer against thermal degradation in polystyrene, and an additive to polyvinyl resins.
• Used as a solvent for aromatic polyamide fibers; also used as a catalyst, stabilizer, and additive for polymers and resins; [ACGIH]
• Textiles (Fiber & Fabric Manufacturing) [Category: Industry]
• Plastic Composites Manufacturing [Category: Industry]
• PROCESSING SOLVENT FOR AROMATIC POLYAMIDE FIBER
• DE-ICING ADDITIVE FOR JET FUELS; /EXPERIMENTAL/ CHEMOSTERILANT FOR A NUMBER OF INSECT PESTS; AS A CHEMICAL MUTAGEN

Synonyms

HEXAMETHYLPHOSPHORAMIDE; 680-31-9; HMPA; Hexamethylphosphoric triamide; Hexametapol; Hempa; HMPTA; Hexamethylphosphoric acid triamide; Phosphoric hexamethyltriamide; Hexamethylphosphorotriamide; Eastman Inhibitor HPT; Phosphoric triamide, hexamethyl-; Hexamethylphosphotriamide; Tris(dimethylamino)phosphine oxide; Hexamethylorthophosphoric triamide; Phosphoric acid hexamethyltriamide

Frequently Asked Questions

What are the CAS number and molecular formula of Hexamethylphosphoramide?

CAS 680-31-9; molecular formula C6H18N3OP; molecular weight — g/mol.

What other names is Hexamethylphosphoramide known by?

HEXAMETHYLPHOSPHORAMIDE, 680-31-9, HMPA, Hexamethylphosphoric triamide, Hexametapol, Hempa.

Is Hexamethylphosphoramide classified as hazardous?

Hazard statements reported: H340, H350, H303, H313, H315.

What are the key physical properties of Hexamethylphosphoramide?

Boiling Point: 451 °F at 760 mmHg (NTP, 1992); Boiling Point: 233 °C @ 760 MM HG; Boiling Point: 232 °C; Boiling Point: 451 °F.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.